Tags

Type your tag names separated by a space and hit enter

Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy.
Diabetes Care. 2003 Feb; 26(2):446-51.DC

Abstract

OBJECTIVE

To assess the efficacy of maggot therapy for treating foot and leg ulcers in diabetic patients failing conventional therapy.

RESEARCH DESIGN AND METHODS

Retrospective comparison of changes in necrotic and total surface area of chronic wounds treated with either maggot therapy or standard (control) surgical or nonsurgical therapy.

RESULTS

In this cohort of 18 patients with 20 nonhealing ulcers, six wounds were treated with conventional therapy, six with maggot therapy, and eight with conventional therapy first, then maggot therapy. Repeated measures ANOVA indicated no significant change in necrotic tissue, except when factoring for treatment (F [1.7, 34] = 5.27, P = 0.013). During the first 14 days of conventional therapy, there was no significant debridement of necrotic tissue; during the same period with maggot therapy, necrotic tissue decreased by an average of 4.1 cm(2) (P = 0.02). After 5 weeks of therapy, conventionally treated wounds were still covered with necrotic tissue over 33% of their surface, whereas after only 4 weeks of therapy maggot-treated wounds were completely debrided (P = 0.001). Maggot therapy was also associated with hastened growth of granulation tissue and greater wound healing rates.

CONCLUSIONS

Maggot therapy was more effective and efficient in debriding nonhealing foot and leg ulcers in male diabetic veterans than was continued conventional care.

Authors+Show Affiliations

Veterans Affairs Medical Center, Long Beach, California and the Department of Medicine, University of California, Irvine 92697, USA. rsherman@uci.edu

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12547878

Citation

Sherman, Ronald A.. "Maggot Therapy for Treating Diabetic Foot Ulcers Unresponsive to Conventional Therapy." Diabetes Care, vol. 26, no. 2, 2003, pp. 446-51.
Sherman RA. Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy. Diabetes Care. 2003;26(2):446-51.
Sherman, R. A. (2003). Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy. Diabetes Care, 26(2), 446-51.
Sherman RA. Maggot Therapy for Treating Diabetic Foot Ulcers Unresponsive to Conventional Therapy. Diabetes Care. 2003;26(2):446-51. PubMed PMID: 12547878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy. A1 - Sherman,Ronald A, PY - 2003/1/28/pubmed PY - 2003/8/2/medline PY - 2003/1/28/entrez SP - 446 EP - 51 JF - Diabetes care JO - Diabetes Care VL - 26 IS - 2 N2 - OBJECTIVE: To assess the efficacy of maggot therapy for treating foot and leg ulcers in diabetic patients failing conventional therapy. RESEARCH DESIGN AND METHODS: Retrospective comparison of changes in necrotic and total surface area of chronic wounds treated with either maggot therapy or standard (control) surgical or nonsurgical therapy. RESULTS: In this cohort of 18 patients with 20 nonhealing ulcers, six wounds were treated with conventional therapy, six with maggot therapy, and eight with conventional therapy first, then maggot therapy. Repeated measures ANOVA indicated no significant change in necrotic tissue, except when factoring for treatment (F [1.7, 34] = 5.27, P = 0.013). During the first 14 days of conventional therapy, there was no significant debridement of necrotic tissue; during the same period with maggot therapy, necrotic tissue decreased by an average of 4.1 cm(2) (P = 0.02). After 5 weeks of therapy, conventionally treated wounds were still covered with necrotic tissue over 33% of their surface, whereas after only 4 weeks of therapy maggot-treated wounds were completely debrided (P = 0.001). Maggot therapy was also associated with hastened growth of granulation tissue and greater wound healing rates. CONCLUSIONS: Maggot therapy was more effective and efficient in debriding nonhealing foot and leg ulcers in male diabetic veterans than was continued conventional care. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/12547878/Maggot_therapy_for_treating_diabetic_foot_ulcers_unresponsive_to_conventional_therapy_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=12547878 DB - PRIME DP - Unbound Medicine ER -