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High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence.

Abstract

OBJECTIVE

Uterine leiomyoma, or fibroid tumors, are the leading indication for hysterectomy in the United States, but the proportion of women in whom fibroid tumors develop is not known. This study screened for fibroid tumors, independently of clinical symptoms, to estimate the age-specific proportion of black and white women in whom fibroid tumors develop.

STUDY DESIGN

Randomly selected members of an urban health plan who were 35 to 49 years old participated (n = 1364 women). Medical records and self-report were used to assess fibroid status for those women who were no longer menstruating (most of whom had had hysterectomies). Premenopausal women were screened by ultrasonography. We estimated the age-specific cumulative incidence of fibroid tumors for black and white women.

RESULTS

Thirty-five percent of premenopausal women had a previous diagnosis of fibroid tumors. Fifty-one percent of the premenopausal women who had no previous diagnosis had ultrasound evidence of fibroid tumors. The estimated cumulative incidence of tumors by age 50 was >80% for black women and nearly 70% for white women. The difference between the age-specific cumulative incidence curves for black and white women was highly significant (odds ratio, 2.9; 95% CI, 2.5-3.4; P <.001).

CONCLUSION

The results of this study suggest that most black and white women in the United States develop uterine fibroid tumors before menopause and that uterine fibroid tumors develop in black women at earlier ages than in white women.

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  • Authors+Show Affiliations

    ,

    Epidemiology Branch and the Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

    , , ,

    Source

    MeSH

    Adult
    African Continental Ancestry Group
    Age Factors
    Body Mass Index
    Educational Status
    European Continental Ancestry Group
    Female
    Humans
    Income
    Leiomyoma
    Middle Aged
    Parity
    Postmenopause
    Premenopause
    Ultrasonography
    Urban Population
    Uterine Neoplasms

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12548202

    Citation

    Baird, Donna Day, et al. "High Cumulative Incidence of Uterine Leiomyoma in Black and White Women: Ultrasound Evidence." American Journal of Obstetrics and Gynecology, vol. 188, no. 1, 2003, pp. 100-7.
    Baird DD, Dunson DB, Hill MC, et al. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188(1):100-7.
    Baird, D. D., Dunson, D. B., Hill, M. C., Cousins, D., & Schectman, J. M. (2003). High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. American Journal of Obstetrics and Gynecology, 188(1), pp. 100-7.
    Baird DD, et al. High Cumulative Incidence of Uterine Leiomyoma in Black and White Women: Ultrasound Evidence. Am J Obstet Gynecol. 2003;188(1):100-7. PubMed PMID: 12548202.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. AU - Baird,Donna Day, AU - Dunson,David B, AU - Hill,Michael C, AU - Cousins,Deborah, AU - Schectman,Joel M, PY - 2003/1/28/pubmed PY - 2003/2/21/medline PY - 2003/1/28/entrez SP - 100 EP - 7 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 188 IS - 1 N2 - OBJECTIVE: Uterine leiomyoma, or fibroid tumors, are the leading indication for hysterectomy in the United States, but the proportion of women in whom fibroid tumors develop is not known. This study screened for fibroid tumors, independently of clinical symptoms, to estimate the age-specific proportion of black and white women in whom fibroid tumors develop. STUDY DESIGN: Randomly selected members of an urban health plan who were 35 to 49 years old participated (n = 1364 women). Medical records and self-report were used to assess fibroid status for those women who were no longer menstruating (most of whom had had hysterectomies). Premenopausal women were screened by ultrasonography. We estimated the age-specific cumulative incidence of fibroid tumors for black and white women. RESULTS: Thirty-five percent of premenopausal women had a previous diagnosis of fibroid tumors. Fifty-one percent of the premenopausal women who had no previous diagnosis had ultrasound evidence of fibroid tumors. The estimated cumulative incidence of tumors by age 50 was >80% for black women and nearly 70% for white women. The difference between the age-specific cumulative incidence curves for black and white women was highly significant (odds ratio, 2.9; 95% CI, 2.5-3.4; P <.001). CONCLUSION: The results of this study suggest that most black and white women in the United States develop uterine fibroid tumors before menopause and that uterine fibroid tumors develop in black women at earlier ages than in white women. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/12548202/High_cumulative_incidence_of_uterine_leiomyoma_in_black_and_white_women:_ultrasound_evidence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937802714294 DB - PRIME DP - Unbound Medicine ER -