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Effect of c-reactive protein and interleukins blood levels in postsurgery arginine-enhanced enteral nutrition in head and neck cancer patients.
Eur J Clin Nutr 2003; 57(1):96-9EJ

Abstract

OBJECTIVE

It is known that the immune system is frequently affected in patients with head and neck cancer. Although immune dysfunction could be multifactorial, this immune system may be modulated by specific nutritional substrates, such as arginine. The aim of our study was to evaluate the effect of enteral nutrition supplemented with arginine on c-reactive protein (CRP), interleukin 6 (IL-6) and tumour necrosis factor (TNFalpha) in surgical head and neck cancer patients.

DESIGN

Randomized trial.

SETTING

Tertiary care.

SUBJECTS

A population of 36 patients with oral and laryngeal cancer were enrolled.

INTERVENTIONS

At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplements with arginine and dietary fibre (group I, n=18); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II, n=18). Perioperatively and on postoperative day 5 the following parameters were evaluated: serum values of prealbumin, transferrin, albumin, total number of lymphocytes, interleukin 6, tumour necrosis factor alpha and c-reactive protein.

RESULTS

The mean age was 59.6+/-10.9 y (two females/34 males). No significant intergroup differences in the trend of the three plasma proteins and weight were detected. CRP decreased in both groups (group I: 152.9+/-76.9 vs 68.9+/-82.5 mg/dl; P<0.05; and group II: 105.9+/-92 vs 43.6+/-59.1 mg/dl; P<0.05). Interleukin 6 did not change (group I: 16.3+/-12.3 vs 35.6+/-83.4 pg/ml; NS; and group II: 22.8+/-40 vs 9.9+/-17.7 pg/ml; NS). TNFalpha did not show any differences (group I: 4.6+/-1.6 vs 5.1+/-1.5 pg/ml; NS; and group II: 8.8+/-6.1 vs 5.8+/-1.7 pg/ml; NS). Lymphocytes increased in both groups (group I: 1405.6+/-517 vs 1634+/-529 x 10(6)/ml; P<0.05; and group II: 1355+/-696 vs 1561+/-541 x 10(6)/ml; P<0.05).

CONCLUSIONS

Enhanced formula did not change IL6 and TNFalpha levels. Further studies are needed to determine whether route of nutrition or type of formula is the key in these patients.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, Valladolid, Spain. ddlr@pulso.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12548303

Citation

de Luis, D A., et al. "Effect of C-reactive Protein and Interleukins Blood Levels in Postsurgery Arginine-enhanced Enteral Nutrition in Head and Neck Cancer Patients." European Journal of Clinical Nutrition, vol. 57, no. 1, 2003, pp. 96-9.
de Luis DA, Izaola O, Cuellar L, et al. Effect of c-reactive protein and interleukins blood levels in postsurgery arginine-enhanced enteral nutrition in head and neck cancer patients. Eur J Clin Nutr. 2003;57(1):96-9.
de Luis, D. A., Izaola, O., Cuellar, L., Terroba, M. C., Arranz, M., Fernandez, N., & Aller, R. (2003). Effect of c-reactive protein and interleukins blood levels in postsurgery arginine-enhanced enteral nutrition in head and neck cancer patients. European Journal of Clinical Nutrition, 57(1), pp. 96-9.
de Luis DA, et al. Effect of C-reactive Protein and Interleukins Blood Levels in Postsurgery Arginine-enhanced Enteral Nutrition in Head and Neck Cancer Patients. Eur J Clin Nutr. 2003;57(1):96-9. PubMed PMID: 12548303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of c-reactive protein and interleukins blood levels in postsurgery arginine-enhanced enteral nutrition in head and neck cancer patients. AU - de Luis,D A, AU - Izaola,O, AU - Cuellar,L, AU - Terroba,M C, AU - Arranz,M, AU - Fernandez,N, AU - Aller,R, PY - 2001/10/24/received PY - 2002/04/11/revised PY - 2002/04/18/accepted PY - 2003/1/28/pubmed PY - 2003/5/30/medline PY - 2003/1/28/entrez SP - 96 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 1 N2 - OBJECTIVE: It is known that the immune system is frequently affected in patients with head and neck cancer. Although immune dysfunction could be multifactorial, this immune system may be modulated by specific nutritional substrates, such as arginine. The aim of our study was to evaluate the effect of enteral nutrition supplemented with arginine on c-reactive protein (CRP), interleukin 6 (IL-6) and tumour necrosis factor (TNFalpha) in surgical head and neck cancer patients. DESIGN: Randomized trial. SETTING: Tertiary care. SUBJECTS: A population of 36 patients with oral and laryngeal cancer were enrolled. INTERVENTIONS: At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplements with arginine and dietary fibre (group I, n=18); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II, n=18). Perioperatively and on postoperative day 5 the following parameters were evaluated: serum values of prealbumin, transferrin, albumin, total number of lymphocytes, interleukin 6, tumour necrosis factor alpha and c-reactive protein. RESULTS: The mean age was 59.6+/-10.9 y (two females/34 males). No significant intergroup differences in the trend of the three plasma proteins and weight were detected. CRP decreased in both groups (group I: 152.9+/-76.9 vs 68.9+/-82.5 mg/dl; P<0.05; and group II: 105.9+/-92 vs 43.6+/-59.1 mg/dl; P<0.05). Interleukin 6 did not change (group I: 16.3+/-12.3 vs 35.6+/-83.4 pg/ml; NS; and group II: 22.8+/-40 vs 9.9+/-17.7 pg/ml; NS). TNFalpha did not show any differences (group I: 4.6+/-1.6 vs 5.1+/-1.5 pg/ml; NS; and group II: 8.8+/-6.1 vs 5.8+/-1.7 pg/ml; NS). Lymphocytes increased in both groups (group I: 1405.6+/-517 vs 1634+/-529 x 10(6)/ml; P<0.05; and group II: 1355+/-696 vs 1561+/-541 x 10(6)/ml; P<0.05). CONCLUSIONS: Enhanced formula did not change IL6 and TNFalpha levels. Further studies are needed to determine whether route of nutrition or type of formula is the key in these patients. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12548303/Effect_of_c_reactive_protein_and_interleukins_blood_levels_in_postsurgery_arginine_enhanced_enteral_nutrition_in_head_and_neck_cancer_patients_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601512 DB - PRIME DP - Unbound Medicine ER -