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Plant sterol-enriched spread enhances the cholesterol-lowering potential of a fat-reduced diet.
Eur J Clin Nutr 2003; 57(1):170-6EJ

Abstract

OBJECTIVE

To determine the effect of a plant sterol-enriched spread on plasma cholesterol concentrations when replacing butter or a standard polyunsaturated spread in a diet containing 30% of energy fat.

DESIGN

Parallel butter phase followed by double-blind, randomized, cross-over polyunsaturated spread phases.

SETTING

General community.

SUBJECTS

Volunteer sample of 50 free-living men and women with mean age (s.d.) 46.7 y (10.5), moderately elevated plasma total cholesterol 5.95 mmol/l (0.78), and body mass index 26.0 (3.9) kg/m(2).

INTERVENTION

Participants ate a moderately low-fat diet (30% of energy) for the 11-week intervention. During the first 3 weeks the diet included 20 g per day of butter. Participants were then randomized to replace the butter with 25 g of polyunsaturated spread with or without 2 g of plant sterols for 4 weeks, crossing over in the last 4 weeks to the alternate spread.

MAIN OUTCOME MEASURES

Plasma cholesterol and fatty acids.

RESULTS

Replacing butter with a standard polyunsaturated fat spread reduced mean plasma total cholesterol concentrations by 4.6% (from 6.09 (0.82) to 5.81 (0.77) mmol/l, P<0.01) and low-density lipoprotein cholesterol by 5.5% (from 3.98 (0.76) to 3.76 (0.74) mmol/l, P<0.05). Replacing butter with a polyunsaturated spread containing plant sterols reduced plasma total cholesterol by 8.9% (from 6.09 (0.82) to 5.55 (0.76) mmol/l, P<0.01) and low density lipoprotein cholesterol by 12.3% (from 3.98 (0.76) to 3.49 (0.72) mmol/l, P<0.01). Plasma high density lipoprotein cholesterol concentration was the same on the three diets.

CONCLUSION

In people with moderately raised plasma cholesterol concentrations consuming reduced-fat diets the reduction in plasma total and low-density lipoprotein cholesterol concentrations achieved by replacing butter with a polyunsaturated spread is enhanced by addition of plant sterols.

Authors+Show Affiliations

Department of Human Nutrition, University of Otago, Dunedin, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12548313

Citation

Cleghorn, C L., et al. "Plant Sterol-enriched Spread Enhances the Cholesterol-lowering Potential of a Fat-reduced Diet." European Journal of Clinical Nutrition, vol. 57, no. 1, 2003, pp. 170-6.
Cleghorn CL, Skeaff CM, Mann J, et al. Plant sterol-enriched spread enhances the cholesterol-lowering potential of a fat-reduced diet. Eur J Clin Nutr. 2003;57(1):170-6.
Cleghorn, C. L., Skeaff, C. M., Mann, J., & Chisholm, A. (2003). Plant sterol-enriched spread enhances the cholesterol-lowering potential of a fat-reduced diet. European Journal of Clinical Nutrition, 57(1), pp. 170-6.
Cleghorn CL, et al. Plant Sterol-enriched Spread Enhances the Cholesterol-lowering Potential of a Fat-reduced Diet. Eur J Clin Nutr. 2003;57(1):170-6. PubMed PMID: 12548313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant sterol-enriched spread enhances the cholesterol-lowering potential of a fat-reduced diet. AU - Cleghorn,C L, AU - Skeaff,C M, AU - Mann,J, AU - Chisholm,A, PY - 2002/01/23/received PY - 2002/05/01/revised PY - 2002/05/16/accepted PY - 2003/1/28/pubmed PY - 2003/5/30/medline PY - 2003/1/28/entrez SP - 170 EP - 6 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 1 N2 - OBJECTIVE: To determine the effect of a plant sterol-enriched spread on plasma cholesterol concentrations when replacing butter or a standard polyunsaturated spread in a diet containing 30% of energy fat. DESIGN: Parallel butter phase followed by double-blind, randomized, cross-over polyunsaturated spread phases. SETTING: General community. SUBJECTS: Volunteer sample of 50 free-living men and women with mean age (s.d.) 46.7 y (10.5), moderately elevated plasma total cholesterol 5.95 mmol/l (0.78), and body mass index 26.0 (3.9) kg/m(2). INTERVENTION: Participants ate a moderately low-fat diet (30% of energy) for the 11-week intervention. During the first 3 weeks the diet included 20 g per day of butter. Participants were then randomized to replace the butter with 25 g of polyunsaturated spread with or without 2 g of plant sterols for 4 weeks, crossing over in the last 4 weeks to the alternate spread. MAIN OUTCOME MEASURES: Plasma cholesterol and fatty acids. RESULTS: Replacing butter with a standard polyunsaturated fat spread reduced mean plasma total cholesterol concentrations by 4.6% (from 6.09 (0.82) to 5.81 (0.77) mmol/l, P<0.01) and low-density lipoprotein cholesterol by 5.5% (from 3.98 (0.76) to 3.76 (0.74) mmol/l, P<0.05). Replacing butter with a polyunsaturated spread containing plant sterols reduced plasma total cholesterol by 8.9% (from 6.09 (0.82) to 5.55 (0.76) mmol/l, P<0.01) and low density lipoprotein cholesterol by 12.3% (from 3.98 (0.76) to 3.49 (0.72) mmol/l, P<0.01). Plasma high density lipoprotein cholesterol concentration was the same on the three diets. CONCLUSION: In people with moderately raised plasma cholesterol concentrations consuming reduced-fat diets the reduction in plasma total and low-density lipoprotein cholesterol concentrations achieved by replacing butter with a polyunsaturated spread is enhanced by addition of plant sterols. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12548313/Plant_sterol_enriched_spread_enhances_the_cholesterol_lowering_potential_of_a_fat_reduced_diet_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601531 DB - PRIME DP - Unbound Medicine ER -