Tags

Type your tag names separated by a space and hit enter

Modification of respiratory function parameters in patients with severe Parkinson's disease.
Neurol Sci. 2002 Sep; 23 Suppl 2:S69-70.NS

Abstract

Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEV1/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients.

Authors+Show Affiliations

Department of Neurology, Villa Margherita-SG Moscati, Rehabilitation Institute of Benevento, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12548348

Citation

De Pandis, M F., et al. "Modification of Respiratory Function Parameters in Patients With Severe Parkinson's Disease." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 23 Suppl 2, 2002, pp. S69-70.
De Pandis MF, Starace A, Stefanelli F, et al. Modification of respiratory function parameters in patients with severe Parkinson's disease. Neurol Sci. 2002;23 Suppl 2:S69-70.
De Pandis, M. F., Starace, A., Stefanelli, F., Marruzzo, P., Meoli, I., De Simone, G., Prati, R., & Stocchi, F. (2002). Modification of respiratory function parameters in patients with severe Parkinson's disease. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 23 Suppl 2, S69-70.
De Pandis MF, et al. Modification of Respiratory Function Parameters in Patients With Severe Parkinson's Disease. Neurol Sci. 2002;23 Suppl 2:S69-70. PubMed PMID: 12548348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modification of respiratory function parameters in patients with severe Parkinson's disease. AU - De Pandis,M F, AU - Starace,A, AU - Stefanelli,F, AU - Marruzzo,P, AU - Meoli,I, AU - De Simone,G, AU - Prati,R, AU - Stocchi,F, PY - 2003/1/28/pubmed PY - 2003/3/29/medline PY - 2003/1/28/entrez SP - S69 EP - 70 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 23 Suppl 2 N2 - Respiratory dysfunction remains one of the most common causes of death in patients with complicated Parkinson's disease (PD). The aim of this study was to investigate pulmonary function in fluctuating PD patients during "on" and "off" states of the disease. We studied 12 fluctuating, non-smoking PD patients (H&Y stages 3-5) without a history of lung or cardiovascular disease; all patients underwent Hoehn and Yahr scale (H&Y) and Unified Parkinson Disease Rating Scale (UPDRS items 18-31) to evaluate extrapyramidal impairment, as well as pulmonary function tests (PFT) and arterial blood gas analyses to assess respiratory function. All evaluations were performed during a stable on state of disease and in an off state produced by 12 hours of therapy withdrawal. A restrictive pattern of flow-volume loop was observed both in on and off states of disease. In the off state, we found a significant worsening in both FEV1 and FVC; the FEV1/FVC ratio was unmodified. These results suggest a restrictive pattern of flow-volume loop in these patients. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/12548348/Modification_of_respiratory_function_parameters_in_patients_with_severe_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -