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Evaluation of risk of Parkinson's disease in a cohort of licensed pesticide users.
Neurol Sci 2002; 23 Suppl 2:S119-20NS

Abstract

In the last two years, the environmental theory on the aetiology of Parkinson disease has acquired new data. From an experimental point of view, a new model of parkinsonism induced by rotenone, a diffuse insecticide, has been proposed, and in vitro studies have provided proof that several pesticides stimulate the formation of alpha-synuclein fibrils (one of the principal constituents of Lewy bodies). Moreover, a meta-analysis of all case-control studies so far performed showed a positive, statistically significant association between pesticide exposure and PD. In this context, we are performing a cohort study on 5575 licensed pesticide users in the province of Viterbo. After 27 years of follow-up, 4788 subjects are still alive. The aim of this study is to measure the prevalence of Parkinson's disease in a large group of workers with theoretically increased risk.

Authors+Show Affiliations

Department of Neurological Sciences, La Sapienza University, Viale dell'Università 30, I-00185 Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12548372

Citation

Vanacore, N, et al. "Evaluation of Risk of Parkinson's Disease in a Cohort of Licensed Pesticide Users." Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, vol. 23 Suppl 2, 2002, pp. S119-20.
Vanacore N, Nappo A, Gentile M, et al. Evaluation of risk of Parkinson's disease in a cohort of licensed pesticide users. Neurol Sci. 2002;23 Suppl 2:S119-20.
Vanacore, N., Nappo, A., Gentile, M., Brustolin, A., Palange, S., Liberati, A., ... Meco, G. (2002). Evaluation of risk of Parkinson's disease in a cohort of licensed pesticide users. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 23 Suppl 2, pp. S119-20.
Vanacore N, et al. Evaluation of Risk of Parkinson's Disease in a Cohort of Licensed Pesticide Users. Neurol Sci. 2002;23 Suppl 2:S119-20. PubMed PMID: 12548372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of risk of Parkinson's disease in a cohort of licensed pesticide users. AU - Vanacore,N, AU - Nappo,A, AU - Gentile,M, AU - Brustolin,A, AU - Palange,S, AU - Liberati,A, AU - Di Rezze,S, AU - Caldora,G, AU - Gasparini,M, AU - Benedetti,F, AU - Bonifati,V, AU - Forastiere,F, AU - Quercia,A, AU - Meco,G, PY - 2003/1/28/pubmed PY - 2003/3/29/medline PY - 2003/1/28/entrez SP - S119 EP - 20 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol. Sci. VL - 23 Suppl 2 N2 - In the last two years, the environmental theory on the aetiology of Parkinson disease has acquired new data. From an experimental point of view, a new model of parkinsonism induced by rotenone, a diffuse insecticide, has been proposed, and in vitro studies have provided proof that several pesticides stimulate the formation of alpha-synuclein fibrils (one of the principal constituents of Lewy bodies). Moreover, a meta-analysis of all case-control studies so far performed showed a positive, statistically significant association between pesticide exposure and PD. In this context, we are performing a cohort study on 5575 licensed pesticide users in the province of Viterbo. After 27 years of follow-up, 4788 subjects are still alive. The aim of this study is to measure the prevalence of Parkinson's disease in a large group of workers with theoretically increased risk. SN - 1590-1874 UR - https://www.unboundmedicine.com/medline/citation/12548372/Evaluation_of_risk_of_Parkinson's_disease_in_a_cohort_of_licensed_pesticide_users_ L2 - https://dx.doi.org/10.1007/s100720200098 DB - PRIME DP - Unbound Medicine ER -