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CB1 cannabinoid receptor signalling in Parkinson's disease.
Curr Opin Pharmacol 2003; 3(1):54-61CO

Abstract

Signalling at CB(1) cannabinoid receptors plays a key role in the control of movement in health and disease. In recent years, an increased understanding of the physiological role of transmission at CB(1) receptors throughout the basal ganglia circuitry has led to the identification of novel therapeutic approaches to both the symptoms of Parkinson's disease and the side effects of current anti-parkinsonian therapies, especially L(3,4) dihydroxyphenylalamine (levodopa)-induced dyskinesia. Thus, because activation of basal ganglia CB(1) receptors can modulate neurotransmission and contribute to synaptic plasticity in a manner similar to that described in other brain regions, it also appears that endocannabinoids might modulate cell-cell signalling via effects on neurotransmitter re-uptake and postsynaptic actions mediating cross talk between multiple receptor types. Recent studies in animal models and in the clinic suggest that CB(1) receptor antagonists could prove useful in the treatment of parkinsonian symptoms and levodopa-induced dyskinesia, whereas CB(1) receptor agonists could have value in reducing levodopa-induced dyskinesia.

Authors+Show Affiliations

Toronto Western Research Institute, Toronto Western Hospital, Bathurst Street, Toronto, ON, Canada. brotchie@uhnres.utoronto.ca

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12550742

Citation

Brotchie, Jonathan M.. "CB1 Cannabinoid Receptor Signalling in Parkinson's Disease." Current Opinion in Pharmacology, vol. 3, no. 1, 2003, pp. 54-61.
Brotchie JM. CB1 cannabinoid receptor signalling in Parkinson's disease. Curr Opin Pharmacol. 2003;3(1):54-61.
Brotchie, J. M. (2003). CB1 cannabinoid receptor signalling in Parkinson's disease. Current Opinion in Pharmacology, 3(1), pp. 54-61.
Brotchie JM. CB1 Cannabinoid Receptor Signalling in Parkinson's Disease. Curr Opin Pharmacol. 2003;3(1):54-61. PubMed PMID: 12550742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CB1 cannabinoid receptor signalling in Parkinson's disease. A1 - Brotchie,Jonathan M, PY - 2003/1/29/pubmed PY - 2003/7/2/medline PY - 2003/1/29/entrez SP - 54 EP - 61 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 3 IS - 1 N2 - Signalling at CB(1) cannabinoid receptors plays a key role in the control of movement in health and disease. In recent years, an increased understanding of the physiological role of transmission at CB(1) receptors throughout the basal ganglia circuitry has led to the identification of novel therapeutic approaches to both the symptoms of Parkinson's disease and the side effects of current anti-parkinsonian therapies, especially L(3,4) dihydroxyphenylalamine (levodopa)-induced dyskinesia. Thus, because activation of basal ganglia CB(1) receptors can modulate neurotransmission and contribute to synaptic plasticity in a manner similar to that described in other brain regions, it also appears that endocannabinoids might modulate cell-cell signalling via effects on neurotransmitter re-uptake and postsynaptic actions mediating cross talk between multiple receptor types. Recent studies in animal models and in the clinic suggest that CB(1) receptor antagonists could prove useful in the treatment of parkinsonian symptoms and levodopa-induced dyskinesia, whereas CB(1) receptor agonists could have value in reducing levodopa-induced dyskinesia. SN - 1471-4892 UR - https://www.unboundmedicine.com/medline/citation/12550742/CB1_cannabinoid_receptor_signalling_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471489202000115 DB - PRIME DP - Unbound Medicine ER -