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Influence of beta-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets.
Eur J Pharm Biopharm. 2003 Jan; 55(1):85-91.EJ

Abstract

The in vitro release profiles of carbamazepine and beta-cyclodextrin either complexed or simply mixed and subsequently incorporated in hydrophilic matrix tablets containing 15 or 30% hydroxypropyl methylcellulose were evaluated. Solubility studies revealed a linear relationship between the increase in carbamazepine solubility and the increase in beta-cyclodextrin concentration. Drying methods (spray-drying and freeze-drying) were used to obtain carbamazepine/beta-cyclodextrin solid complexes in order to prepare tablets. The results demonstrated that matrix tablets containing carbamazepine/beta-cyclodextrin solid complexes displayed faster carbamazepine and beta-cyclodextrin release compared to that containing simple physical mixture. Gelling and matrix formation was impaired in formulation containing 15% hydroxypropyl methylcellulose and spray-dried complex. The comparison of spray-drying and freeze-drying revealed no significant influence of both drying methods on carbamazepine and beta-cyclodextrin dissolution rate when carbamazepine/beta-cyclodextrin complexes were incorporated in 30% hydroxypropyl methylcellulose matrix tablets. The results point to the possibility of modulating carbamazepine release using a hydroxypropyl methylcellulose matrix associated to the drug complexed with beta-cyclodextrin.

Authors+Show Affiliations

Programa de Pós-graduação em Ciências Farmacêuticas, Porto Alegre, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12551708

Citation

Koester, Letícia S., et al. "Influence of Beta-cyclodextrin Complexation On Carbamazepine Release From Hydroxypropyl Methylcellulose Matrix Tablets." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 55, no. 1, 2003, pp. 85-91.
Koester LS, Xavier CR, Mayorga P, et al. Influence of beta-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets. Eur J Pharm Biopharm. 2003;55(1):85-91.
Koester, L. S., Xavier, C. R., Mayorga, P., & Bassani, V. L. (2003). Influence of beta-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 55(1), 85-91.
Koester LS, et al. Influence of Beta-cyclodextrin Complexation On Carbamazepine Release From Hydroxypropyl Methylcellulose Matrix Tablets. Eur J Pharm Biopharm. 2003;55(1):85-91. PubMed PMID: 12551708.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of beta-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets. AU - Koester,Letícia S, AU - Xavier,Clarissa R, AU - Mayorga,Paulo, AU - Bassani,Valquiria L, PY - 2003/1/29/pubmed PY - 2003/9/27/medline PY - 2003/1/29/entrez SP - 85 EP - 91 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 55 IS - 1 N2 - The in vitro release profiles of carbamazepine and beta-cyclodextrin either complexed or simply mixed and subsequently incorporated in hydrophilic matrix tablets containing 15 or 30% hydroxypropyl methylcellulose were evaluated. Solubility studies revealed a linear relationship between the increase in carbamazepine solubility and the increase in beta-cyclodextrin concentration. Drying methods (spray-drying and freeze-drying) were used to obtain carbamazepine/beta-cyclodextrin solid complexes in order to prepare tablets. The results demonstrated that matrix tablets containing carbamazepine/beta-cyclodextrin solid complexes displayed faster carbamazepine and beta-cyclodextrin release compared to that containing simple physical mixture. Gelling and matrix formation was impaired in formulation containing 15% hydroxypropyl methylcellulose and spray-dried complex. The comparison of spray-drying and freeze-drying revealed no significant influence of both drying methods on carbamazepine and beta-cyclodextrin dissolution rate when carbamazepine/beta-cyclodextrin complexes were incorporated in 30% hydroxypropyl methylcellulose matrix tablets. The results point to the possibility of modulating carbamazepine release using a hydroxypropyl methylcellulose matrix associated to the drug complexed with beta-cyclodextrin. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/12551708/Influence_of_beta_cyclodextrin_complexation_on_carbamazepine_release_from_hydroxypropyl_methylcellulose_matrix_tablets_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939641102001273 DB - PRIME DP - Unbound Medicine ER -