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Effect of GB virus C coinfection on response to antiretroviral treatment in human immunodeficiency virus-infected patients.
J Infect Dis. 2003 Feb 01; 187(3):504-7.JI

Abstract

To study how GB virus C (GBV-C) coinfection affects the response to highly active antiretroviral therapy (HAART), 146 human immunodeficiency virus (HIV)-infected patients were tested for GBV-C RNA and antibodies against GBV-C E2 protein, and responses to HAART were evaluated. GBV-C-infected patients exhibited a complete virological response to HAART more often than patients without [correction] GBV-C and had a greater increase in median CD4 cell count and a marginally greater median HIV RNA level decrease. This association was found to be independent of baseline CD4 cell count and plasma HIV RNA, which indicates that an association exists between GBV-C infection and response to HAART.

Authors+Show Affiliations

University Hospitals of Cleveland and Case Western Reserve University Center for AIDS Research, Cleveland, Ohio 44106, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12552436

Citation

Rodriguez, Benigno, et al. "Effect of GB Virus C Coinfection On Response to Antiretroviral Treatment in Human Immunodeficiency Virus-infected Patients." The Journal of Infectious Diseases, vol. 187, no. 3, 2003, pp. 504-7.
Rodriguez B, Woolley I, Lederman MM, et al. Effect of GB virus C coinfection on response to antiretroviral treatment in human immunodeficiency virus-infected patients. J Infect Dis. 2003;187(3):504-7.
Rodriguez, B., Woolley, I., Lederman, M. M., Zdunek, D., Hess, G., & Valdez, H. (2003). Effect of GB virus C coinfection on response to antiretroviral treatment in human immunodeficiency virus-infected patients. The Journal of Infectious Diseases, 187(3), 504-7.
Rodriguez B, et al. Effect of GB Virus C Coinfection On Response to Antiretroviral Treatment in Human Immunodeficiency Virus-infected Patients. J Infect Dis. 2003 Feb 1;187(3):504-7. PubMed PMID: 12552436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of GB virus C coinfection on response to antiretroviral treatment in human immunodeficiency virus-infected patients. AU - Rodriguez,Benigno, AU - Woolley,Ian, AU - Lederman,Michael M, AU - Zdunek,Dietmar, AU - Hess,Georg, AU - Valdez,Hernán, Y1 - 2003/01/24/ PY - 2002/05/01/received PY - 2002/10/15/revised PY - 2003/1/29/pubmed PY - 2003/3/11/medline PY - 2003/1/29/entrez SP - 504 EP - 7 JF - The Journal of infectious diseases JO - J Infect Dis VL - 187 IS - 3 N2 - To study how GB virus C (GBV-C) coinfection affects the response to highly active antiretroviral therapy (HAART), 146 human immunodeficiency virus (HIV)-infected patients were tested for GBV-C RNA and antibodies against GBV-C E2 protein, and responses to HAART were evaluated. GBV-C-infected patients exhibited a complete virological response to HAART more often than patients without [correction] GBV-C and had a greater increase in median CD4 cell count and a marginally greater median HIV RNA level decrease. This association was found to be independent of baseline CD4 cell count and plasma HIV RNA, which indicates that an association exists between GBV-C infection and response to HAART. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12552436/Effect_of_GB_virus_C_coinfection_on_response_to_antiretroviral_treatment_in_human_immunodeficiency_virus_infected_patients_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/368206 DB - PRIME DP - Unbound Medicine ER -