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Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies.
Am J Kidney Dis 2003; 41(2):319-27AJ

Abstract

BACKGROUND

Proteinuria is a recognized complication of obesity, but no study has investigated the effect of weight loss in overweight patients with chronic proteinuric nephropathies of different causes.

METHODS

We randomly assigned (in a 2:1 ratio) 30 overweight patients (body mass index [BMI] > 27 kg/m(2)) with diabetic and nondiabetic proteinuric nephropathies to either follow a low-calorie normoproteinic diet or maintain their usual dietary intake for 5 months. The primary outcome was change in urinary protein excretion. Secondary outcomes were changes in renal function (serum creatinine level and Cockcroft-Gault creatinine clearance) and lipid profile.

RESULTS

Patients in the diet group showed a significant decrease in body weight and BMI, whereas patients in the control group showed a significant increase in body weight and BMI (between-group comparison, P < 0.05). Mean weight loss in the diet group was 4.1% +/- 3%, and 14 of 20 patients in this group lost more than 3%. Proteinuria decreased by 31.2% +/- 37% in the diet group (from protein of 2.8 +/- 1.4 to 1.9 +/- 1.4 g/24 h; P < 0.005), whereas it tended to increase in the control group (between-group comparison, P < 0.05). Changes in renal function did not differ significantly between groups, although renal function remained stable in the diet group and showed significant worsening in the control group. Serum triglyceride levels remained stable in the diet group and tended to increase in the control group (between-group comparison, P < 0.05).

CONCLUSION

Moderate weight loss in overweight patients with chronic proteinuric nephropathies induces a significant decrease in proteinuria. Am J Kidney Dis 41:319-327.

Authors+Show Affiliations

Departments of Nephrology and Endocrinology, Hospital Universitario 12 de Octubre, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12552492

Citation

Morales, Enrique, et al. "Beneficial Effects of Weight Loss in Overweight Patients With Chronic Proteinuric Nephropathies." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 41, no. 2, 2003, pp. 319-27.
Morales E, Valero MA, León M, et al. Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies. Am J Kidney Dis. 2003;41(2):319-27.
Morales, E., Valero, M. A., León, M., Hernández, E., & Praga, M. (2003). Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 41(2), pp. 319-27.
Morales E, et al. Beneficial Effects of Weight Loss in Overweight Patients With Chronic Proteinuric Nephropathies. Am J Kidney Dis. 2003;41(2):319-27. PubMed PMID: 12552492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies. AU - Morales,Enrique, AU - Valero,Ma Angeles, AU - León,Miguel, AU - Hernández,Eduardo, AU - Praga,Manuel, PY - 2003/1/29/pubmed PY - 2003/2/15/medline PY - 2003/1/29/entrez SP - 319 EP - 27 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 41 IS - 2 N2 - BACKGROUND: Proteinuria is a recognized complication of obesity, but no study has investigated the effect of weight loss in overweight patients with chronic proteinuric nephropathies of different causes. METHODS: We randomly assigned (in a 2:1 ratio) 30 overweight patients (body mass index [BMI] > 27 kg/m(2)) with diabetic and nondiabetic proteinuric nephropathies to either follow a low-calorie normoproteinic diet or maintain their usual dietary intake for 5 months. The primary outcome was change in urinary protein excretion. Secondary outcomes were changes in renal function (serum creatinine level and Cockcroft-Gault creatinine clearance) and lipid profile. RESULTS: Patients in the diet group showed a significant decrease in body weight and BMI, whereas patients in the control group showed a significant increase in body weight and BMI (between-group comparison, P < 0.05). Mean weight loss in the diet group was 4.1% +/- 3%, and 14 of 20 patients in this group lost more than 3%. Proteinuria decreased by 31.2% +/- 37% in the diet group (from protein of 2.8 +/- 1.4 to 1.9 +/- 1.4 g/24 h; P < 0.005), whereas it tended to increase in the control group (between-group comparison, P < 0.05). Changes in renal function did not differ significantly between groups, although renal function remained stable in the diet group and showed significant worsening in the control group. Serum triglyceride levels remained stable in the diet group and tended to increase in the control group (between-group comparison, P < 0.05). CONCLUSION: Moderate weight loss in overweight patients with chronic proteinuric nephropathies induces a significant decrease in proteinuria. Am J Kidney Dis 41:319-327. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/12552492/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272638602691413 DB - PRIME DP - Unbound Medicine ER -