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Physical activity, body fat, and serum C-reactive protein in postmenopausal women with and without hormone replacement.
Am J Hum Biol 2003 Jan-Feb; 15(1):91-100AJ

Abstract

The objective was to determine whether higher physical activity is associated with lower serum C-reactive protein (CRP), independent of oral hormone replacement therapy (HRT) status and body fatness, in 133 postmenopausal women using a cross-sectional exploratory design at a university research laboratory. The subjects were 133 postmenopausal women, age 50-73 years, with no evidence of coronary artery disease or diabetes. The main outcome measures were: serum CRP, physical activity as measured by Stanford 7-day activity recall, body fat (both total and regional) as measured by dual energy X-ray absorptiometry (DXA), and anthropometry (waist and hip circumference). Secondary outcome measures included fasting plasma glucose and insulin as well as fasting serum triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Higher physical activity energy expenditures were significantly associated with lower serum CRP levels (r = -0.18, P = 0.041), independent of oral HRT use, age, smoking behavior, alcohol consumption, aspirin use, and statin use. However, in the complete multivariate model, which included body fat, older ages (P = 0.047), greater trunk fat masses (P < 0.001), any oral HRT use (P < 0.001), and unopposed oral estrogen use (P = 0.012) were the sole independent predictors of higher serum CRP levels. The complete multivariate model accounted for 58% of the variance in serum CRP. We conclude that the association between higher physical activity and lower serum CRP levels is dependent on the lower body fat of the more active women, yet independent of oral HRT use. Future intervention trials should determine whether diet- and exercise-related reductions in body fat may be effective ways to diminish the proinflammatory effects of oral HRT in postmenopausal women.

Authors+Show Affiliations

Department of Exercise and Sport Science, College of Health and Human Performance, Oregon State University, Corvallis, Oregon, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12552583

Citation

Manns, Patricia J., et al. "Physical Activity, Body Fat, and Serum C-reactive Protein in Postmenopausal Women With and Without Hormone Replacement." American Journal of Human Biology : the Official Journal of the Human Biology Council, vol. 15, no. 1, 2003, pp. 91-100.
Manns PJ, Williams DP, Snow CM, et al. Physical activity, body fat, and serum C-reactive protein in postmenopausal women with and without hormone replacement. Am J Hum Biol. 2003;15(1):91-100.
Manns, P. J., Williams, D. P., Snow, C. M., & Wander, R. C. (2003). Physical activity, body fat, and serum C-reactive protein in postmenopausal women with and without hormone replacement. American Journal of Human Biology : the Official Journal of the Human Biology Council, 15(1), pp. 91-100.
Manns PJ, et al. Physical Activity, Body Fat, and Serum C-reactive Protein in Postmenopausal Women With and Without Hormone Replacement. Am J Hum Biol. 2003;15(1):91-100. PubMed PMID: 12552583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity, body fat, and serum C-reactive protein in postmenopausal women with and without hormone replacement. AU - Manns,Patricia J, AU - Williams,Daniel P, AU - Snow,Christine M, AU - Wander,Rosemary C, PY - 2003/1/29/pubmed PY - 2003/2/8/medline PY - 2003/1/29/entrez SP - 91 EP - 100 JF - American journal of human biology : the official journal of the Human Biology Council JO - Am. J. Hum. Biol. VL - 15 IS - 1 N2 - The objective was to determine whether higher physical activity is associated with lower serum C-reactive protein (CRP), independent of oral hormone replacement therapy (HRT) status and body fatness, in 133 postmenopausal women using a cross-sectional exploratory design at a university research laboratory. The subjects were 133 postmenopausal women, age 50-73 years, with no evidence of coronary artery disease or diabetes. The main outcome measures were: serum CRP, physical activity as measured by Stanford 7-day activity recall, body fat (both total and regional) as measured by dual energy X-ray absorptiometry (DXA), and anthropometry (waist and hip circumference). Secondary outcome measures included fasting plasma glucose and insulin as well as fasting serum triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Higher physical activity energy expenditures were significantly associated with lower serum CRP levels (r = -0.18, P = 0.041), independent of oral HRT use, age, smoking behavior, alcohol consumption, aspirin use, and statin use. However, in the complete multivariate model, which included body fat, older ages (P = 0.047), greater trunk fat masses (P < 0.001), any oral HRT use (P < 0.001), and unopposed oral estrogen use (P = 0.012) were the sole independent predictors of higher serum CRP levels. The complete multivariate model accounted for 58% of the variance in serum CRP. We conclude that the association between higher physical activity and lower serum CRP levels is dependent on the lower body fat of the more active women, yet independent of oral HRT use. Future intervention trials should determine whether diet- and exercise-related reductions in body fat may be effective ways to diminish the proinflammatory effects of oral HRT in postmenopausal women. SN - 1042-0533 UR - https://www.unboundmedicine.com/medline/citation/12552583/Physical_activity_body_fat_and_serum_C_reactive_protein_in_postmenopausal_women_with_and_without_hormone_replacement_ L2 - https://doi.org/10.1002/ajhb.10117 DB - PRIME DP - Unbound Medicine ER -