Tags

Type your tag names separated by a space and hit enter

Diastereo- and enantioselective catalytic carbometallative aldol cycloreduction: tandem conjugate addition-aldol cyclization.
J Am Chem Soc. 2003 Feb 05; 125(5):1110-1.JA

Abstract

A catalytic diastereo- and enantioselective method for tandem conjugate addition-aldol cyclization is described. This methodology enables the formation of five- and six-membered ring products from aromatic and aliphatic mono-enone mono-ketone precursors. Notably, in a single manipulation, three contiguous stereogenic centers are created with high levels of relative and absolute stereocontrol.

Authors+Show Affiliations

Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12553780

Citation

Cauble, David F., et al. "Diastereo- and Enantioselective Catalytic Carbometallative Aldol Cycloreduction: Tandem Conjugate Addition-aldol Cyclization." Journal of the American Chemical Society, vol. 125, no. 5, 2003, pp. 1110-1.
Cauble DF, Gipson JD, Krische MJ. Diastereo- and enantioselective catalytic carbometallative aldol cycloreduction: tandem conjugate addition-aldol cyclization. J Am Chem Soc. 2003;125(5):1110-1.
Cauble, D. F., Gipson, J. D., & Krische, M. J. (2003). Diastereo- and enantioselective catalytic carbometallative aldol cycloreduction: tandem conjugate addition-aldol cyclization. Journal of the American Chemical Society, 125(5), 1110-1.
Cauble DF, Gipson JD, Krische MJ. Diastereo- and Enantioselective Catalytic Carbometallative Aldol Cycloreduction: Tandem Conjugate Addition-aldol Cyclization. J Am Chem Soc. 2003 Feb 5;125(5):1110-1. PubMed PMID: 12553780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diastereo- and enantioselective catalytic carbometallative aldol cycloreduction: tandem conjugate addition-aldol cyclization. AU - Cauble,David F, AU - Gipson,John D, AU - Krische,Michael J, PY - 2003/1/30/pubmed PY - 2003/4/2/medline PY - 2003/1/30/entrez SP - 1110 EP - 1 JF - Journal of the American Chemical Society JO - J Am Chem Soc VL - 125 IS - 5 N2 - A catalytic diastereo- and enantioselective method for tandem conjugate addition-aldol cyclization is described. This methodology enables the formation of five- and six-membered ring products from aromatic and aliphatic mono-enone mono-ketone precursors. Notably, in a single manipulation, three contiguous stereogenic centers are created with high levels of relative and absolute stereocontrol. SN - 0002-7863 UR - https://www.unboundmedicine.com/medline/citation/12553780/Diastereo__and_enantioselective_catalytic_carbometallative_aldol_cycloreduction:_tandem_conjugate_addition_aldol_cyclization_ L2 - https://doi.org/10.1021/ja0211095 DB - PRIME DP - Unbound Medicine ER -