Tags

Type your tag names separated by a space and hit enter

In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices.
J Pharm Pharm Sci. 2002 Sep-Dec; 5(3):213-9.JP

Abstract

PURPOSE

The objective of this study was to develop uncoated HPMC matrix tablets, evaluating the relationship and influence of different content levels of microcrystalline cellulose (MCC), starch, and lactose, in order to achieve a zero-order release of Diclofenac Sodium.

METHODS

HPMC matrix tablets of Diclofenac Sodium using microcrystalline cellulose (MCC), starch, and lactose were prepared by wet granulation process. The USP paddle method was selected to perform the dissolution profiles carried out in 900 mL 0.1 N HCl, and phosphate buffer.

RESULTS

There was no significant difference in drug release between the hydrophilic matrices when the HPMC concentration was modified in low percentage. Release kinetics of Diclofenac Sodium from these swollen matrices was principally regulated by starch (17 percent) or lactose (17 percent), even on the presence of MCC. When starch (8.5 percent) and lactose (8.5 percent) were mixed at lower concentration in a ratio 1:1, MCC (5 percent or 7,5 percent) appeared to control the drug release. The release profile remained unchanged after three months storage of tablets. The best-fit release kinetics was achieved with the zero-order plot, followed by the Higuchi and first-order equations. The data obtained proved that the formulations are useful for a sustained release of Diclofenac, due to the percentage released after 8 hours is nearly to 70 percent.

CONCLUSIONS

The release of Diclofenac Sodium was influenced by the presence of MCC, and by the different concentrations of starch and lactose. Drug release kinetics from these formulations corresponded best to the zero-order kinetics. Compared to conventional tablets, release of the model drug from these HPMC matrix tablets was prolonged; as a result, an oral release dosage form to avoid the gastrointestinal adverse effects was achieved.

Authors+Show Affiliations

Department of Pharmacy, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12553888

Citation

Bravo, Silvina A., et al. "In-vitro Studies of Diclofenac Sodium Controlled-release From Biopolymeric Hydrophilic Matrices." Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, vol. 5, no. 3, 2002, pp. 213-9.
Bravo SA, Lamas MC, Salamón CJ. In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices. J Pharm Pharm Sci. 2002;5(3):213-9.
Bravo, S. A., Lamas, M. C., & Salamón, C. J. (2002). In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques, 5(3), 213-9.
Bravo SA, Lamas MC, Salamón CJ. In-vitro Studies of Diclofenac Sodium Controlled-release From Biopolymeric Hydrophilic Matrices. J Pharm Pharm Sci. 2002 Sep-Dec;5(3):213-9. PubMed PMID: 12553888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices. AU - Bravo,Silvina A, AU - Lamas,Maria C, AU - Salamón,Claudio J, PY - 2003/1/30/pubmed PY - 2003/3/18/medline PY - 2003/1/30/entrez SP - 213 EP - 9 JF - Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques JO - J Pharm Pharm Sci VL - 5 IS - 3 N2 - PURPOSE: The objective of this study was to develop uncoated HPMC matrix tablets, evaluating the relationship and influence of different content levels of microcrystalline cellulose (MCC), starch, and lactose, in order to achieve a zero-order release of Diclofenac Sodium. METHODS: HPMC matrix tablets of Diclofenac Sodium using microcrystalline cellulose (MCC), starch, and lactose were prepared by wet granulation process. The USP paddle method was selected to perform the dissolution profiles carried out in 900 mL 0.1 N HCl, and phosphate buffer. RESULTS: There was no significant difference in drug release between the hydrophilic matrices when the HPMC concentration was modified in low percentage. Release kinetics of Diclofenac Sodium from these swollen matrices was principally regulated by starch (17 percent) or lactose (17 percent), even on the presence of MCC. When starch (8.5 percent) and lactose (8.5 percent) were mixed at lower concentration in a ratio 1:1, MCC (5 percent or 7,5 percent) appeared to control the drug release. The release profile remained unchanged after three months storage of tablets. The best-fit release kinetics was achieved with the zero-order plot, followed by the Higuchi and first-order equations. The data obtained proved that the formulations are useful for a sustained release of Diclofenac, due to the percentage released after 8 hours is nearly to 70 percent. CONCLUSIONS: The release of Diclofenac Sodium was influenced by the presence of MCC, and by the different concentrations of starch and lactose. Drug release kinetics from these formulations corresponded best to the zero-order kinetics. Compared to conventional tablets, release of the model drug from these HPMC matrix tablets was prolonged; as a result, an oral release dosage form to avoid the gastrointestinal adverse effects was achieved. SN - 1482-1826 UR - https://www.unboundmedicine.com/medline/citation/12553888/In_vitro_studies_of_diclofenac_sodium_controlled_release_from_biopolymeric_hydrophilic_matrices_ L2 - http://www.ualberta.ca/~csps/JPPS5(3)/S.Bravo/diclofenac.htm DB - PRIME DP - Unbound Medicine ER -