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[Prevention of colorectal cancer in families with hereditary nonpolyposis colorectal cancer].
Ugeskr Laeger. 2003 Jan 13; 165(3):221-5.UL

Abstract

INTRODUCTION

Hereditary non-polyposis colorectal cancer (HNPCC) is a dominant inherited colorectal cancer syndrome, with lifetime risk up to 90% of developing colorectal cancer (CRC) for carriers of the genes. Screening with colonoscopy can reduce the CRC-rate by 62% and prevent CRC-deaths. The HNPCC-Register was established with the aim of identification and registration of Danish HNPCC-families and coordination of surveillance.

MATERIALS AND METHODS

The results of 703 colonic screenings in 396 asymptomatic individuals from 150 HNPCC-families were analysed and related to the family diagnosis.

RESULTS

In 112 asymptomatic individuals, 31, colorectal cancers and 140 adenomas were diagnosed. Neoplasia was found in one fifth of the examinations and almost one third of the individuals developed an asymptomatic neoplasia which was detected by screening. At the time of the diagnosis, 77% of the colorectal cancers were localized (Dukes stage A or B).

DISCUSSION

In Finland, screening for colorectal cancers in HNPCC-families prevents 25-45-fold more CRC-deaths compared to general population screening for colorectal cancer. The results of the Danish colonic HNPCC-screening reveal neoplasia in 21% of the examinations and the colorectal cancers found by screening were at a more favourable Dukes stage compared to sporadic CRC, and probably also CRC found by general population screening. The HNPCC-Register initiates surveillance together with the clinical genetic departments, but the results of the recommended colonic examinations are not automatically reported to the HNPCC-Register. To enable an in-depth investigation of the effect of CRC-screening in all Danish HNPCC-families, further financial resources should be allocated to the HNPCC-Register to collect the results.

Authors+Show Affiliations

HNPCC-registret, gastroenheden, kirurgisk afsnit 435, H:S Hvidovre Hospital, Kettegårds Allé, DK-2650 Hvidovre.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

dan

PubMed ID

12555703

Citation

Bernstein, Inge T., et al. "[Prevention of Colorectal Cancer in Families With Hereditary Nonpolyposis Colorectal Cancer]." Ugeskrift for Laeger, vol. 165, no. 3, 2003, pp. 221-5.
Bernstein IT, Bisgaard ML, Myrhøj T. [Prevention of colorectal cancer in families with hereditary nonpolyposis colorectal cancer]. Ugeskr Laeg. 2003;165(3):221-5.
Bernstein, I. T., Bisgaard, M. L., & Myrhøj, T. (2003). [Prevention of colorectal cancer in families with hereditary nonpolyposis colorectal cancer]. Ugeskrift for Laeger, 165(3), 221-5.
Bernstein IT, Bisgaard ML, Myrhøj T. [Prevention of Colorectal Cancer in Families With Hereditary Nonpolyposis Colorectal Cancer]. Ugeskr Laeg. 2003 Jan 13;165(3):221-5. PubMed PMID: 12555703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prevention of colorectal cancer in families with hereditary nonpolyposis colorectal cancer]. AU - Bernstein,Inge T, AU - Bisgaard,Marie Luise, AU - Myrhøj,Torben, PY - 2003/1/31/pubmed PY - 2003/3/8/medline PY - 2003/1/31/entrez SP - 221 EP - 5 JF - Ugeskrift for laeger JO - Ugeskr. Laeg. VL - 165 IS - 3 N2 - INTRODUCTION: Hereditary non-polyposis colorectal cancer (HNPCC) is a dominant inherited colorectal cancer syndrome, with lifetime risk up to 90% of developing colorectal cancer (CRC) for carriers of the genes. Screening with colonoscopy can reduce the CRC-rate by 62% and prevent CRC-deaths. The HNPCC-Register was established with the aim of identification and registration of Danish HNPCC-families and coordination of surveillance. MATERIALS AND METHODS: The results of 703 colonic screenings in 396 asymptomatic individuals from 150 HNPCC-families were analysed and related to the family diagnosis. RESULTS: In 112 asymptomatic individuals, 31, colorectal cancers and 140 adenomas were diagnosed. Neoplasia was found in one fifth of the examinations and almost one third of the individuals developed an asymptomatic neoplasia which was detected by screening. At the time of the diagnosis, 77% of the colorectal cancers were localized (Dukes stage A or B). DISCUSSION: In Finland, screening for colorectal cancers in HNPCC-families prevents 25-45-fold more CRC-deaths compared to general population screening for colorectal cancer. The results of the Danish colonic HNPCC-screening reveal neoplasia in 21% of the examinations and the colorectal cancers found by screening were at a more favourable Dukes stage compared to sporadic CRC, and probably also CRC found by general population screening. The HNPCC-Register initiates surveillance together with the clinical genetic departments, but the results of the recommended colonic examinations are not automatically reported to the HNPCC-Register. To enable an in-depth investigation of the effect of CRC-screening in all Danish HNPCC-families, further financial resources should be allocated to the HNPCC-Register to collect the results. SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/12555703/[Prevention_of_colorectal_cancer_in_families_with_hereditary_nonpolyposis_colorectal_cancer]_ L2 - http://www.diseaseinfosearch.org/result/3345 DB - PRIME DP - Unbound Medicine ER -