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Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis.
Am J Trop Med Hyg 2003; 68(1):89-91AJ

Abstract

Possible coinfections with Orientia tsutsugamushi the causative agent of scrub typhus, were prospectively evaluated in rice farmers hospitalized with leptospirosis in Northeast Thailand. Of 22 adults with leptospirosis diagnosed by the microscopic agglutination test, 9 also had serologic evidence of scrub typhus. Of 9 individuals with possible coinfections, 5 had signs or symptoms typical of scrub typhus and atypical of leptospirosis. Patients who appeared to have mixed infections had significantly higher median platelet counts and significantly lower median serum bilirubin and creatinine concentrations (P < 0.05, Mann-Whitney U test) than did individuals with leptospirosis alone. One patient with serologic evidence of scrub typhus and leptospirosis was treated only with penicillin, to which scrub typhus is not sensitive. Respiratory distress worsened during therapy, and the patient died of respiratory failure. Physicians should consider the possibility of scrub typhus infection in leptospirosis patients who respond poorly to treatment or who have atypical disease manifestations.

Authors+Show Affiliations

Department of Retrovirology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. wattgh@thai.amedd.army.milNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12556154

Citation

Watt, George, et al. "Possible Scrub Typhus Coinfections in Thai Agricultural Workers Hospitalized With Leptospirosis." The American Journal of Tropical Medicine and Hygiene, vol. 68, no. 1, 2003, pp. 89-91.
Watt G, Jongsakul K, Suttinont C. Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis. Am J Trop Med Hyg. 2003;68(1):89-91.
Watt, G., Jongsakul, K., & Suttinont, C. (2003). Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis. The American Journal of Tropical Medicine and Hygiene, 68(1), pp. 89-91.
Watt G, Jongsakul K, Suttinont C. Possible Scrub Typhus Coinfections in Thai Agricultural Workers Hospitalized With Leptospirosis. Am J Trop Med Hyg. 2003;68(1):89-91. PubMed PMID: 12556154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible scrub typhus coinfections in Thai agricultural workers hospitalized with leptospirosis. AU - Watt,George, AU - Jongsakul,Krisada, AU - Suttinont,Chuanpit, PY - 2003/1/31/pubmed PY - 2003/2/4/medline PY - 2003/1/31/entrez SP - 89 EP - 91 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 68 IS - 1 N2 - Possible coinfections with Orientia tsutsugamushi the causative agent of scrub typhus, were prospectively evaluated in rice farmers hospitalized with leptospirosis in Northeast Thailand. Of 22 adults with leptospirosis diagnosed by the microscopic agglutination test, 9 also had serologic evidence of scrub typhus. Of 9 individuals with possible coinfections, 5 had signs or symptoms typical of scrub typhus and atypical of leptospirosis. Patients who appeared to have mixed infections had significantly higher median platelet counts and significantly lower median serum bilirubin and creatinine concentrations (P < 0.05, Mann-Whitney U test) than did individuals with leptospirosis alone. One patient with serologic evidence of scrub typhus and leptospirosis was treated only with penicillin, to which scrub typhus is not sensitive. Respiratory distress worsened during therapy, and the patient died of respiratory failure. Physicians should consider the possibility of scrub typhus infection in leptospirosis patients who respond poorly to treatment or who have atypical disease manifestations. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/12556154/Possible_scrub_typhus_coinfections_in_Thai_agricultural_workers_hospitalized_with_leptospirosis_ L2 - http://www.ajtmh.org/cgi/pmidlookup?view=long&amp;pmid=12556154 DB - PRIME DP - Unbound Medicine ER -