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Expression of tumor necrosis factor-alpha in regenerating muscle fibers in inflammatory and non-inflammatory myopathies.
Acta Neuropathol. 2003 Mar; 105(3):217-24.AN

Abstract

The expression level of tumor necrosis factor (TNF)-alpha is elevated in idiopathic inflammatory myopathies and Duchenne muscular dystrophy (DMD), but the precise role of TNF-alpha is unknown. To elucidate the possible role of TNF-alpha, we investigated the expression of TNF-alpha and its receptor in polymyositis (PM), dermatomyositis (DM), and DMD using in situ hybridization (ISH) and immunohistochemistry. We showed that TNF-alpha mRNA and protein were present in muscle fibers. TNF-alpha-positive fibers were observed in all cases of PM, DM and DMD, but were rare or absent in neurogenic disorders and normal controls. The proportion of TNF-alpha-positive fiber showed a significant positive correlation with the proportion of regenerating fibers that were positive for the developmental form of myosin heavy chain (MHC-d). The number of TNF receptor-positive fibers was small. Some muscle fibers expressed both TNF-alpha and its receptor simultaneously. Our results indicate that TNF-alpha is produced and expressed by muscle fibers and associated with muscle regeneration.

Authors+Show Affiliations

Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12557007

Citation

Kuru, Satoshi, et al. "Expression of Tumor Necrosis Factor-alpha in Regenerating Muscle Fibers in Inflammatory and Non-inflammatory Myopathies." Acta Neuropathologica, vol. 105, no. 3, 2003, pp. 217-24.
Kuru S, Inukai A, Kato T, et al. Expression of tumor necrosis factor-alpha in regenerating muscle fibers in inflammatory and non-inflammatory myopathies. Acta Neuropathol. 2003;105(3):217-24.
Kuru, S., Inukai, A., Kato, T., Liang, Y., Kimura, S., & Sobue, G. (2003). Expression of tumor necrosis factor-alpha in regenerating muscle fibers in inflammatory and non-inflammatory myopathies. Acta Neuropathologica, 105(3), 217-24.
Kuru S, et al. Expression of Tumor Necrosis Factor-alpha in Regenerating Muscle Fibers in Inflammatory and Non-inflammatory Myopathies. Acta Neuropathol. 2003;105(3):217-24. PubMed PMID: 12557007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of tumor necrosis factor-alpha in regenerating muscle fibers in inflammatory and non-inflammatory myopathies. AU - Kuru,Satoshi, AU - Inukai,Akira, AU - Kato,Takashi, AU - Liang,Yideng, AU - Kimura,Seigo, AU - Sobue,Gen, Y1 - 2002/11/22/ PY - 2002/07/08/received PY - 2002/08/19/revised PY - 2002/09/25/accepted PY - 2003/1/31/pubmed PY - 2003/4/24/medline PY - 2003/1/31/entrez SP - 217 EP - 24 JF - Acta neuropathologica JO - Acta Neuropathol VL - 105 IS - 3 N2 - The expression level of tumor necrosis factor (TNF)-alpha is elevated in idiopathic inflammatory myopathies and Duchenne muscular dystrophy (DMD), but the precise role of TNF-alpha is unknown. To elucidate the possible role of TNF-alpha, we investigated the expression of TNF-alpha and its receptor in polymyositis (PM), dermatomyositis (DM), and DMD using in situ hybridization (ISH) and immunohistochemistry. We showed that TNF-alpha mRNA and protein were present in muscle fibers. TNF-alpha-positive fibers were observed in all cases of PM, DM and DMD, but were rare or absent in neurogenic disorders and normal controls. The proportion of TNF-alpha-positive fiber showed a significant positive correlation with the proportion of regenerating fibers that were positive for the developmental form of myosin heavy chain (MHC-d). The number of TNF receptor-positive fibers was small. Some muscle fibers expressed both TNF-alpha and its receptor simultaneously. Our results indicate that TNF-alpha is produced and expressed by muscle fibers and associated with muscle regeneration. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/12557007/Expression_of_tumor_necrosis_factor_alpha_in_regenerating_muscle_fibers_in_inflammatory_and_non_inflammatory_myopathies_ L2 - https://dx.doi.org/10.1007/s00401-002-0635-4 DB - PRIME DP - Unbound Medicine ER -