Tags

Type your tag names separated by a space and hit enter

Pycnogenol inhibits the release of histamine from mast cells.
Phytother Res. 2003 Jan; 17(1):66-9.PR

Abstract

Oxygen derived free radicals are now increasingly regarded as a primary force of tissue destruction and also have the ability to release histamine from mast cells. Pycnogenol is an extract of the bark of French maritime pine (Pinus pinaster) containing bioflavonoids with a potent ability to scavenge free radicals. Therefore Pycnogenol was investigated for inhibition of histamine release from rat peritoneal mast cells. In addition, its effects were compared with sodium cromoglycate, a known inhibitor of histamine release from the mast cell. Rat peritoneal mast cells were isolated and purified by differential centrifugation and cells pooled from 3-4 animals were suspended at approximately 10(6) cells/mL buffered salt solution. Histamine release was induced by compound 48/80 or the calcium ionophore A-23187 and estimated from supernatant following extraction and by fluorimetric methods. Pycnogenol produced a concentration dependent inhibition of histamine release induced by the two secretagogues. Its inhibitory effect on mast cell histamine release was favourably comparable to sodium cromoglycate.

Authors+Show Affiliations

Department of Pharmacology and Therapeutics, Trinity College, Dublin-2, Ireland. ssharma@tcd.ieNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12557250

Citation

Sharma, S C., et al. "Pycnogenol Inhibits the Release of Histamine From Mast Cells." Phytotherapy Research : PTR, vol. 17, no. 1, 2003, pp. 66-9.
Sharma SC, Sharma S, Gulati OP. Pycnogenol inhibits the release of histamine from mast cells. Phytother Res. 2003;17(1):66-9.
Sharma, S. C., Sharma, S., & Gulati, O. P. (2003). Pycnogenol inhibits the release of histamine from mast cells. Phytotherapy Research : PTR, 17(1), 66-9.
Sharma SC, Sharma S, Gulati OP. Pycnogenol Inhibits the Release of Histamine From Mast Cells. Phytother Res. 2003;17(1):66-9. PubMed PMID: 12557250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pycnogenol inhibits the release of histamine from mast cells. AU - Sharma,S C, AU - Sharma,S, AU - Gulati,O P, PY - 2003/1/31/pubmed PY - 2003/4/18/medline PY - 2003/1/31/entrez SP - 66 EP - 9 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 1 N2 - Oxygen derived free radicals are now increasingly regarded as a primary force of tissue destruction and also have the ability to release histamine from mast cells. Pycnogenol is an extract of the bark of French maritime pine (Pinus pinaster) containing bioflavonoids with a potent ability to scavenge free radicals. Therefore Pycnogenol was investigated for inhibition of histamine release from rat peritoneal mast cells. In addition, its effects were compared with sodium cromoglycate, a known inhibitor of histamine release from the mast cell. Rat peritoneal mast cells were isolated and purified by differential centrifugation and cells pooled from 3-4 animals were suspended at approximately 10(6) cells/mL buffered salt solution. Histamine release was induced by compound 48/80 or the calcium ionophore A-23187 and estimated from supernatant following extraction and by fluorimetric methods. Pycnogenol produced a concentration dependent inhibition of histamine release induced by the two secretagogues. Its inhibitory effect on mast cell histamine release was favourably comparable to sodium cromoglycate. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/12557250/Pycnogenol_inhibits_the_release_of_histamine_from_mast_cells_ L2 - https://doi.org/10.1002/ptr.1240 DB - PRIME DP - Unbound Medicine ER -