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Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation.
Phytother Res. 2003 Jan; 17(1):77-9.PR

Abstract

The antiinflammatory activity of an alcohol extract of Achyranthes aspera was tested on carrageenin-induced hind paw oedema and cotton pellet granuloma models in albino male rats. The paw volume was measured plethysmometrically at 0, 1, 2, 3, 4 and 5 h. In the subacute model cotton pellet granuloma was produced by implantation of 50 +/- 1 mg sterile cotton in the axilla under ether anaesthesia. The animals were fed with an alcohol extract at various dose levels (125, 250, 375 and 500 mg/kg). Diclofenac sodium was used as a standard drug. The alcohol extract (375 and 500 mg/kg) showed the maximum inhibition of oedema of 65.38% and 72.37% at the end of 3 h with carrageenin-induced rat paw oedema, respectively. Using a chronic test, the extract exhibited a 40.03% and 45.32% reduction in granuloma weight.

Authors+Show Affiliations

Vetrichelvan T
Adhiparasakthi College of Pharmacy, Melmaruvathur-603 319, Tamil Nadu, India. vetrisel@yahoo.com
Jegadeesan M
No affiliation info available

MeSH

AchyranthesAnimalsAnti-Inflammatory AgentsCarrageenanDiclofenacDose-Response Relationship, DrugEdemaGranulomaMalePhytotherapyPlant ExtractsRatsSeverity of Illness Index

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12557252

Citation

Vetrichelvan, T, and M Jegadeesan. "Effect of Alcohol Extract of Achyranthes Aspera Linn. On Acute and Subacute Inflammation." Phytotherapy Research : PTR, vol. 17, no. 1, 2003, pp. 77-9.
Vetrichelvan T, Jegadeesan M. Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation. Phytother Res. 2003;17(1):77-9.
Vetrichelvan, T., & Jegadeesan, M. (2003). Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation. Phytotherapy Research : PTR, 17(1), 77-9.
Vetrichelvan T, Jegadeesan M. Effect of Alcohol Extract of Achyranthes Aspera Linn. On Acute and Subacute Inflammation. Phytother Res. 2003;17(1):77-9. PubMed PMID: 12557252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation. AU - Vetrichelvan,T, AU - Jegadeesan,M, PY - 2003/1/31/pubmed PY - 2003/4/18/medline PY - 2003/1/31/entrez SP - 77 EP - 9 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 1 N2 - The antiinflammatory activity of an alcohol extract of Achyranthes aspera was tested on carrageenin-induced hind paw oedema and cotton pellet granuloma models in albino male rats. The paw volume was measured plethysmometrically at 0, 1, 2, 3, 4 and 5 h. In the subacute model cotton pellet granuloma was produced by implantation of 50 +/- 1 mg sterile cotton in the axilla under ether anaesthesia. The animals were fed with an alcohol extract at various dose levels (125, 250, 375 and 500 mg/kg). Diclofenac sodium was used as a standard drug. The alcohol extract (375 and 500 mg/kg) showed the maximum inhibition of oedema of 65.38% and 72.37% at the end of 3 h with carrageenin-induced rat paw oedema, respectively. Using a chronic test, the extract exhibited a 40.03% and 45.32% reduction in granuloma weight. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/12557252/Effect_of_alcohol_extract_of_Achyranthes_aspera_Linn__on_acute_and_subacute_inflammation_ DB - PRIME DP - Unbound Medicine ER -