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Treatment of cutaneous leishmaniasis with either topical paromomycin or intralesional meglumine antimoniate.
Clin Exp Dermatol. 2003 Jan; 28(1):13-6.CE

Abstract

Ninety-six patients with a clinical and parasitological diagnosis of cutaneous leishmaniasis were recruited to a comparative randomized clinical trial evaluating the efficacy of topical paromomycin vs. weekly intralesional injections of meglumine antimoniate. The patients were randomly divided into two treatment groups: one group was treated with topical paromomycin ointment and the other with intralesional meglumine antimoniate. Treatment was continued in both groups until complete recovery occurred (defined as healing in less than 2 months with no residual scar or relapse for up to 1 year post treatment). Treatment failure was defined as an increase in the number and size of pre-existing lesions or untoward side-effects. The maximum treatment period was 3 months. The patients were followed up for 1 year. The results showed that intralesional meglumine antimoniate led to 41.7% complete recovery, However, topical paromomycin gave a lower cure rate of 16.6% (P < 0.05). Treatment failure was observed in 39.7% of the group receiving intralesional meglumine and in 72.9% of those on topical paromomycin (P < 0.05). This study indicates that intralesional meglumine antimoniate is superior to topical paromomycin in the treatment of cutaneous leishmaniasis.

Authors+Show Affiliations

Leishmaniasis Research Center, Isfahan University Medical College, Isfahan, Iran. yaldarad22@yahoo.comNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12558620

Citation

Faghihi, G, and R Tavakoli-kia. "Treatment of Cutaneous Leishmaniasis With Either Topical Paromomycin or Intralesional Meglumine Antimoniate." Clinical and Experimental Dermatology, vol. 28, no. 1, 2003, pp. 13-6.
Faghihi G, Tavakoli-kia R. Treatment of cutaneous leishmaniasis with either topical paromomycin or intralesional meglumine antimoniate. Clin Exp Dermatol. 2003;28(1):13-6.
Faghihi, G., & Tavakoli-kia, R. (2003). Treatment of cutaneous leishmaniasis with either topical paromomycin or intralesional meglumine antimoniate. Clinical and Experimental Dermatology, 28(1), 13-6.
Faghihi G, Tavakoli-kia R. Treatment of Cutaneous Leishmaniasis With Either Topical Paromomycin or Intralesional Meglumine Antimoniate. Clin Exp Dermatol. 2003;28(1):13-6. PubMed PMID: 12558620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of cutaneous leishmaniasis with either topical paromomycin or intralesional meglumine antimoniate. AU - Faghihi,G, AU - Tavakoli-kia,R, PY - 2003/2/1/pubmed PY - 2003/4/26/medline PY - 2003/2/1/entrez SP - 13 EP - 6 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 28 IS - 1 N2 - Ninety-six patients with a clinical and parasitological diagnosis of cutaneous leishmaniasis were recruited to a comparative randomized clinical trial evaluating the efficacy of topical paromomycin vs. weekly intralesional injections of meglumine antimoniate. The patients were randomly divided into two treatment groups: one group was treated with topical paromomycin ointment and the other with intralesional meglumine antimoniate. Treatment was continued in both groups until complete recovery occurred (defined as healing in less than 2 months with no residual scar or relapse for up to 1 year post treatment). Treatment failure was defined as an increase in the number and size of pre-existing lesions or untoward side-effects. The maximum treatment period was 3 months. The patients were followed up for 1 year. The results showed that intralesional meglumine antimoniate led to 41.7% complete recovery, However, topical paromomycin gave a lower cure rate of 16.6% (P < 0.05). Treatment failure was observed in 39.7% of the group receiving intralesional meglumine and in 72.9% of those on topical paromomycin (P < 0.05). This study indicates that intralesional meglumine antimoniate is superior to topical paromomycin in the treatment of cutaneous leishmaniasis. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/12558620/Treatment_of_cutaneous_leishmaniasis_with_either_topical_paromomycin_or_intralesional_meglumine_antimoniate_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0307-6938&amp;date=2003&amp;volume=28&amp;issue=1&amp;spage=13 DB - PRIME DP - Unbound Medicine ER -