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Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men.
Mol Genet Metab. 2003 Jan; 78(1):31-6.MG

Abstract

The dyslipidemic state of visceral obesity is characterized by increased plasma triglyceride (TG) levels, low HDL-cholesterol concentrations and alterations in LDL composition and concentration. A functional, non-coding -514C>T single nucleotide polymorphism (SNP) of the hepatic lipase gene (LIPC) has been related to variation in HDL-cholesterol concentrations.

OBJECTIVES

To investigate the hypotheses that the LIPC -514C>T polymorphism may be associated with a deteriorated lipoprotein-lipid profile and that environmental factor, such as abdominal obesity, alters this association.

METHODS

A total of 235 French-Canadian men from the greater Quebec City area were assigned into three groups on the basis of their LIPC -514C>T SNP, including 149 CC homozygotes, 75 CT heterozygotes, and 11 TT homozygotes.

RESULTS

In the present study, the highest values of BMI, waist circumference, and accumulation of visceral adipose tissue (VAT) were observed among TT homozygotes (p<0.05). After adjustment for age and BMI, TT homozygotes still showed higher plasma apolipoprotein (apo) AI and HDL-TG concentrations than the two other groups (p<0.05). When the two genotype groups (CC vs CT/TT) were further divided on the basis of VAT accumulation using a cut-off point of 130 cm(2) (high vs low) it appears that irrespective of the genotype subjects with low VAT had higher HDL(2)-cholesterol concentrations (p<0.0001). However, lean carriers of the T allele had higher plasma HDL(2)-cholesterol levels than lean CC homozygotes. The beneficial effect of the T allele on plasma HDL(2)-cholesterol levels was abolished in the presence of visceral obesity (VAT>130 cm(2)).

CONCLUSION

In summary, the presence of visceral obesity attenuates the impact of the LIPC -514C>T polymorphism on plasma HDL(2)-cholesterol levels.

Authors+Show Affiliations

Dyslipidemia, Diabetes and Atherosclerosis Group and the Community Genetics Research Center, Complexe Hospitalier de la Sagamie, Que, Chicoutimi, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12559845

Citation

St-Pierre, Julie, et al. "Visceral Obesity Attenuates the Effect of the Hepatic Lipase -514C>T Polymorphism On Plasma HDL-cholesterol Levels in French-Canadian Men." Molecular Genetics and Metabolism, vol. 78, no. 1, 2003, pp. 31-6.
St-Pierre J, Miller-Felix I, Paradis ME, et al. Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men. Mol Genet Metab. 2003;78(1):31-6.
St-Pierre, J., Miller-Felix, I., Paradis, M. E., Bergeron, J., Lamarche, B., Després, J. P., Gaudet, D., & Vohl, M. C. (2003). Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men. Molecular Genetics and Metabolism, 78(1), 31-6.
St-Pierre J, et al. Visceral Obesity Attenuates the Effect of the Hepatic Lipase -514C>T Polymorphism On Plasma HDL-cholesterol Levels in French-Canadian Men. Mol Genet Metab. 2003;78(1):31-6. PubMed PMID: 12559845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visceral obesity attenuates the effect of the hepatic lipase -514C>T polymorphism on plasma HDL-cholesterol levels in French-Canadian men. AU - St-Pierre,Julie, AU - Miller-Felix,Isabelle, AU - Paradis,Marie-Eve, AU - Bergeron,Jean, AU - Lamarche,Benoît, AU - Després,Jean-Pierre, AU - Gaudet,Daniel, AU - Vohl,Marie-Claude, PY - 2003/2/1/pubmed PY - 2003/7/10/medline PY - 2003/2/1/entrez SP - 31 EP - 6 JF - Molecular genetics and metabolism JO - Mol Genet Metab VL - 78 IS - 1 N2 - UNLABELLED: The dyslipidemic state of visceral obesity is characterized by increased plasma triglyceride (TG) levels, low HDL-cholesterol concentrations and alterations in LDL composition and concentration. A functional, non-coding -514C>T single nucleotide polymorphism (SNP) of the hepatic lipase gene (LIPC) has been related to variation in HDL-cholesterol concentrations. OBJECTIVES: To investigate the hypotheses that the LIPC -514C>T polymorphism may be associated with a deteriorated lipoprotein-lipid profile and that environmental factor, such as abdominal obesity, alters this association. METHODS: A total of 235 French-Canadian men from the greater Quebec City area were assigned into three groups on the basis of their LIPC -514C>T SNP, including 149 CC homozygotes, 75 CT heterozygotes, and 11 TT homozygotes. RESULTS: In the present study, the highest values of BMI, waist circumference, and accumulation of visceral adipose tissue (VAT) were observed among TT homozygotes (p<0.05). After adjustment for age and BMI, TT homozygotes still showed higher plasma apolipoprotein (apo) AI and HDL-TG concentrations than the two other groups (p<0.05). When the two genotype groups (CC vs CT/TT) were further divided on the basis of VAT accumulation using a cut-off point of 130 cm(2) (high vs low) it appears that irrespective of the genotype subjects with low VAT had higher HDL(2)-cholesterol concentrations (p<0.0001). However, lean carriers of the T allele had higher plasma HDL(2)-cholesterol levels than lean CC homozygotes. The beneficial effect of the T allele on plasma HDL(2)-cholesterol levels was abolished in the presence of visceral obesity (VAT>130 cm(2)). CONCLUSION: In summary, the presence of visceral obesity attenuates the impact of the LIPC -514C>T polymorphism on plasma HDL(2)-cholesterol levels. SN - 1096-7192 UR - https://www.unboundmedicine.com/medline/citation/12559845/Visceral_obesity_attenuates_the_effect_of_the_hepatic_lipase__514C>T_polymorphism_on_plasma_HDL_cholesterol_levels_in_French_Canadian_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096719202002238 DB - PRIME DP - Unbound Medicine ER -