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[Association between apolipoprotein E gene polymorphism and the patients with persistent vegetative state in the Chinese].
Yi Chuan Xue Bao. 2002 Sep; 29(9):757-60.YC

Abstract

We studied the relationship between apolipoprotein E gene polymorphism and persistent vegetative state (PVS) to explore the genetics background of PVS, and evaluated the effect of ApoE gene polymorphism on lipid levels in plasma. The ApoE genotype of fifty-six patients with PVS and fifty-three controls were determined by PCR and restriction fragment length polymorphism (PCR-RFLP). Plasma lipid levels were measured by using routine methods. Results demonstrated that there were five genotypes in the two groups: E3/3, E3/4, E2/2, E2/3 and E2/4. The genotype frequencies of ApoE gene in PVS were 21(37.5%), 26(46.4%), 2 (3.6%), 5(8.9%), 2(3.6%) and that in control were 37(69.8%), 7(13.2%), 2(3.8%) 5(9.4%), 2(3.8%) respectively. We compared the genotype frequencies between the two groups and found there was a significantly increase in E3/4(chi 2 = 14.236, P < 0.001) and decrease in E3/3(chi 2 = 5.348, P < 0.05). epsilon 2, epsilon 3 and epsilon 4 allele frequencies of ApoE were 11(9.8%), 73(65.2%), 28(25%) in PVS and were 11 (10.4%), 86(81.1%), 9(8.5%) in control respectively. Allele frequencies, significantly increased in epsilon 4 (chi 2 = 10.533, P < 0.001) and decreased in epsilon 3 (chi 2 = 7.022, P < 0.01). We also found that E3/4, E2/4 genotype and epsilon 4 allele can largely increase total cholesterol (TC) and lower density lipoprotein cholesterol (LDL-C) levels in plasma, and epsilon 2 alleles also can largely increase LDL-C levels inplasma. Our finding indicates that the ApoE gene polymorphism may be in association with the PVS, and may be a factor in the genetic susceptibility to PVS in Chinese; Genotype and alleles of ApoE in PVS can affect the lipid levels in plasma.

Authors+Show Affiliations

Hu XF
Department of Biology, Nanjing Normal University, Nanjing 210097, China. huxuefang8177@sina.com.cn
Zhang XR
No affiliation info available
Xue A
No affiliation info available
Cao XR
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overAllelesApolipoproteins ECholesterolCholesterol, LDLDNAFemaleGene FrequencyGenotypeHumansMaleMiddle AgedPersistent Vegetative StatePolymorphism, GeneticPolymorphism, Restriction Fragment LengthTriglycerides

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

12561220

Citation

Hu, Xue-Fang, et al. "[Association Between Apolipoprotein E Gene Polymorphism and the Patients With Persistent Vegetative State in the Chinese]." Yi Chuan Xue Bao = Acta Genetica Sinica, vol. 29, no. 9, 2002, pp. 757-60.
Hu XF, Zhang XR, Xue A, et al. [Association between apolipoprotein E gene polymorphism and the patients with persistent vegetative state in the Chinese]. Yi Chuan Xue Bao. 2002;29(9):757-60.
Hu, X. F., Zhang, X. R., Xue, A., & Cao, X. R. (2002). [Association between apolipoprotein E gene polymorphism and the patients with persistent vegetative state in the Chinese]. Yi Chuan Xue Bao = Acta Genetica Sinica, 29(9), 757-60.
Hu XF, et al. [Association Between Apolipoprotein E Gene Polymorphism and the Patients With Persistent Vegetative State in the Chinese]. Yi Chuan Xue Bao. 2002;29(9):757-60. PubMed PMID: 12561220.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association between apolipoprotein E gene polymorphism and the patients with persistent vegetative state in the Chinese]. AU - Hu,Xue-Fang, AU - Zhang,Xi-Ran, AU - Xue,An, AU - Cao,Xiang-Rong, PY - 2003/2/4/pubmed PY - 2003/6/14/medline PY - 2003/2/4/entrez SP - 757 EP - 60 JF - Yi chuan xue bao = Acta genetica Sinica JO - Yi Chuan Xue Bao VL - 29 IS - 9 N2 - We studied the relationship between apolipoprotein E gene polymorphism and persistent vegetative state (PVS) to explore the genetics background of PVS, and evaluated the effect of ApoE gene polymorphism on lipid levels in plasma. The ApoE genotype of fifty-six patients with PVS and fifty-three controls were determined by PCR and restriction fragment length polymorphism (PCR-RFLP). Plasma lipid levels were measured by using routine methods. Results demonstrated that there were five genotypes in the two groups: E3/3, E3/4, E2/2, E2/3 and E2/4. The genotype frequencies of ApoE gene in PVS were 21(37.5%), 26(46.4%), 2 (3.6%), 5(8.9%), 2(3.6%) and that in control were 37(69.8%), 7(13.2%), 2(3.8%) 5(9.4%), 2(3.8%) respectively. We compared the genotype frequencies between the two groups and found there was a significantly increase in E3/4(chi 2 = 14.236, P < 0.001) and decrease in E3/3(chi 2 = 5.348, P < 0.05). epsilon 2, epsilon 3 and epsilon 4 allele frequencies of ApoE were 11(9.8%), 73(65.2%), 28(25%) in PVS and were 11 (10.4%), 86(81.1%), 9(8.5%) in control respectively. Allele frequencies, significantly increased in epsilon 4 (chi 2 = 10.533, P < 0.001) and decreased in epsilon 3 (chi 2 = 7.022, P < 0.01). We also found that E3/4, E2/4 genotype and epsilon 4 allele can largely increase total cholesterol (TC) and lower density lipoprotein cholesterol (LDL-C) levels in plasma, and epsilon 2 alleles also can largely increase LDL-C levels inplasma. Our finding indicates that the ApoE gene polymorphism may be in association with the PVS, and may be a factor in the genetic susceptibility to PVS in Chinese; Genotype and alleles of ApoE in PVS can affect the lipid levels in plasma. SN - 0379-4172 UR - https://www.unboundmedicine.com/medline/citation/12561220/[Association_between_apolipoprotein_E_gene_polymorphism_and_the_patients_with_persistent_vegetative_state_in_the_Chinese]_ DB - PRIME DP - Unbound Medicine ER -