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[Allergen sensitization and asthma in children from 1 to 3 years of age].
Rev Alerg Mex 2002 Nov-Dec; 49(6):171-5RA

Abstract

BACKGROUND

Asthma is a multifactorial disease. Children with atopy history could be sensitized with indoor and food allergens from early stages of the life and this predispose to develop asthma. Controversy exists about the factors that increase or decrease the risk of disease, such as breast feeding, early weaning, smoking exposition, immunizations.

OBJECTIVE

To determine if these risk factors and inhaled and food allergen sensitization predispose to asthma development.

METHODS

A case-control study was performed. Cases (1 to 3 year-old 74 children) with asthma and control (74 healthy age-matched children) were included, r2 = 0.90. Skin-prick test (SPT) was performed by using indoor and food allergens. Test was considered positive if skin reaction was equal or higher than 3 mm. The results were compared by means of the x2 test. A logistic regression analysis was performed for obtaining odds ratio (OR) (95% confidence interval for each factor).

RESULTS

Out of the SPT carried out with aero-allergens, 23 (31%) were positive in the two groups. Regarding the food, 27 cases (36.4%) and 15 controls (20.2%) were positive (x2 = 4.7); p < 0.05, OR = 2.2, IC 95% (1.6-3.1). Atopy was positive in 50 (67.5%) cases and 39 (52.7%) of the controls (x2 = 3.4); p < 0.05, OR 1.8 (1.3 to 2.5). The weaning before the first three months of life was positive in 44 (59.4%) of the cases against 15 (20.2%) of the controls (x2 = 23.7) p < 0.05 with a OR 5.7 (4.9 at 6.6).

CONCLUSIONS

We found a probability 2.2 times higher for developing asthma when children were sensitive to at least one food. We also reported that 100% of our sensitized cases with food had received breast feeding during the first four months of life, which is similar to results of other authors where the breast feeding during an intermediate time (one to six months) does not protect against allergic disease. Early introduction of solid food (before the three months of age) was the main factor increasing probability for developing asthma. In our study, atopy almost duplicated this probability.

Authors+Show Affiliations

Departamento alergia e inmunología clínica, Hospital Infantil de México Federico Gómez, Dr. Márquez 162, col. Doctores, 06720 México, DF.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

12561648

Citation

Rosas Vargas, Miguel Angel, et al. "[Allergen Sensitization and Asthma in Children From 1 to 3 Years of Age]." Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993), vol. 49, no. 6, 2002, pp. 171-5.
Rosas Vargas MA, González Reyes M, del Río Navarro BE, et al. [Allergen sensitization and asthma in children from 1 to 3 years of age]. Rev Alerg Mex. 2002;49(6):171-5.
Rosas Vargas, M. A., González Reyes, M., del Río Navarro, B. E., Avila Castañón, L., Velázquez Armenta, Y., & Sienra Monge, J. J. (2002). [Allergen sensitization and asthma in children from 1 to 3 years of age]. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993), 49(6), pp. 171-5.
Rosas Vargas MA, et al. [Allergen Sensitization and Asthma in Children From 1 to 3 Years of Age]. Rev Alerg Mex. 2002;49(6):171-5. PubMed PMID: 12561648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Allergen sensitization and asthma in children from 1 to 3 years of age]. AU - Rosas Vargas,Miguel Angel, AU - González Reyes,Mario, AU - del Río Navarro,Blanca Estela, AU - Avila Castañón,Lourdes, AU - Velázquez Armenta,Yadira, AU - Sienra Monge,Juan José Luis, PY - 2003/2/4/pubmed PY - 2003/3/18/medline PY - 2003/2/4/entrez SP - 171 EP - 5 JF - Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) JO - Rev Alerg Mex VL - 49 IS - 6 N2 - BACKGROUND: Asthma is a multifactorial disease. Children with atopy history could be sensitized with indoor and food allergens from early stages of the life and this predispose to develop asthma. Controversy exists about the factors that increase or decrease the risk of disease, such as breast feeding, early weaning, smoking exposition, immunizations. OBJECTIVE: To determine if these risk factors and inhaled and food allergen sensitization predispose to asthma development. METHODS: A case-control study was performed. Cases (1 to 3 year-old 74 children) with asthma and control (74 healthy age-matched children) were included, r2 = 0.90. Skin-prick test (SPT) was performed by using indoor and food allergens. Test was considered positive if skin reaction was equal or higher than 3 mm. The results were compared by means of the x2 test. A logistic regression analysis was performed for obtaining odds ratio (OR) (95% confidence interval for each factor). RESULTS: Out of the SPT carried out with aero-allergens, 23 (31%) were positive in the two groups. Regarding the food, 27 cases (36.4%) and 15 controls (20.2%) were positive (x2 = 4.7); p < 0.05, OR = 2.2, IC 95% (1.6-3.1). Atopy was positive in 50 (67.5%) cases and 39 (52.7%) of the controls (x2 = 3.4); p < 0.05, OR 1.8 (1.3 to 2.5). The weaning before the first three months of life was positive in 44 (59.4%) of the cases against 15 (20.2%) of the controls (x2 = 23.7) p < 0.05 with a OR 5.7 (4.9 at 6.6). CONCLUSIONS: We found a probability 2.2 times higher for developing asthma when children were sensitive to at least one food. We also reported that 100% of our sensitized cases with food had received breast feeding during the first four months of life, which is similar to results of other authors where the breast feeding during an intermediate time (one to six months) does not protect against allergic disease. Early introduction of solid food (before the three months of age) was the main factor increasing probability for developing asthma. In our study, atopy almost duplicated this probability. SN - 0002-5151 UR - https://www.unboundmedicine.com/medline/citation/12561648/[Allergen_sensitization_and_asthma_in_children_from_1_to_3_years_of_age]_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -