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Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats.
Indian J Exp Biol 2000; 38(9):916-20IJ

Abstract

Nitrosoamines such as N-nitrosodiethylamine (NDEA) produce oxidative stress due to generation of reactive oxygen species and may alter antioxidant defence system in the tissues. NDEA was administered ip as a single dose to rats in LD50 or in lower amounts and the animals were sacrificed after 0-48 hr of treatment. The results showed that lipid peroxidation in liver increased, however no significant increase in kidney LPO was observed after NDEA administration. Superoxide dismutase (SOD) and glutathione reductase (GSH-R) activity increased in liver, however, catalase (CAT) activity in liver was inhibited in NDEA treated rats. Kidney showed an increase in SOD activity after an initial decrease along with increase in GSH-R activity in NDEA treated rats. However, kidney CAT activity was not significantly altered in NDEA intoxicated rats. Serum transaminases, serum alkaline phosphatase blood urea nitrogen, serum creatinine and scrum proteins were elevated in NDEA treated rats. The results indicate NDEA-induced oxidative stress and alteration in antioxidant enzymes in liver and kidney to neutralise oxidative stress.

Authors+Show Affiliations

Department of Biochemistry, Govt. Medical College, Patiala 147 001, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12561951

Citation

Bansal, A K., et al. "Hepatic and Renal Oxidative Stress in Acute Toxicity of N-nitrosodiethylamine in Rats." Indian Journal of Experimental Biology, vol. 38, no. 9, 2000, pp. 916-20.
Bansal AK, Trivedi R, Soni GL, et al. Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats. Indian J Exp Biol. 2000;38(9):916-20.
Bansal, A. K., Trivedi, R., Soni, G. L., & Bhatnagar, D. (2000). Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats. Indian Journal of Experimental Biology, 38(9), pp. 916-20.
Bansal AK, et al. Hepatic and Renal Oxidative Stress in Acute Toxicity of N-nitrosodiethylamine in Rats. Indian J Exp Biol. 2000;38(9):916-20. PubMed PMID: 12561951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats. AU - Bansal,A K, AU - Trivedi,R, AU - Soni,G L, AU - Bhatnagar,D, PY - 2003/2/4/pubmed PY - 2003/3/4/medline PY - 2003/2/4/entrez SP - 916 EP - 20 JF - Indian journal of experimental biology JO - Indian J. Exp. Biol. VL - 38 IS - 9 N2 - Nitrosoamines such as N-nitrosodiethylamine (NDEA) produce oxidative stress due to generation of reactive oxygen species and may alter antioxidant defence system in the tissues. NDEA was administered ip as a single dose to rats in LD50 or in lower amounts and the animals were sacrificed after 0-48 hr of treatment. The results showed that lipid peroxidation in liver increased, however no significant increase in kidney LPO was observed after NDEA administration. Superoxide dismutase (SOD) and glutathione reductase (GSH-R) activity increased in liver, however, catalase (CAT) activity in liver was inhibited in NDEA treated rats. Kidney showed an increase in SOD activity after an initial decrease along with increase in GSH-R activity in NDEA treated rats. However, kidney CAT activity was not significantly altered in NDEA intoxicated rats. Serum transaminases, serum alkaline phosphatase blood urea nitrogen, serum creatinine and scrum proteins were elevated in NDEA treated rats. The results indicate NDEA-induced oxidative stress and alteration in antioxidant enzymes in liver and kidney to neutralise oxidative stress. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/12561951/Hepatic_and_renal_oxidative_stress_in_acute_toxicity_of_N_nitrosodiethylamine_in_rats_ DB - PRIME DP - Unbound Medicine ER -