Tags

Type your tag names separated by a space and hit enter

Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats.
J Lipid Res. 2003 May; 44(5):893-901.JL

Abstract

To investigate whether dietary fatty acid (FA) composition and energy restriction (ER) interactively influence obese (ob) gene expression, rats consumed diets containing beef tallow, safflower, or fish oil ad libitum (AL) or at 60% AL intake. Circulating leptin concentrations were higher (P < 0.0001) after AL feeding, but were not influenced by dietary fat. ER decreased (P < 0.0001) weight gain and visceral adipose weight, which were positively correlated (r = 0.40 P < 0.001, r = 0.58 P < 0.0001) with circulating leptin levels. Visceral adipose ob mRNA levels were greater in animals fed unsaturated fats, particularly safflower oil, which had the highest ob mRNA levels. Circulating leptin levels did not parallel ob mRNA levels, except for the greater abundance detected in AL adipose in comparison to ER animals. In addition, visceral FA profiles reflected dietary fat source and were influenced by an interaction of dietary fat and energy. These data demonstrate that dietary fat, particularly from a plant or marine source, and ER interactively influence ob mRNA levels; however, alterations in ob mRNA do not confer changes in circulating leptin, with the exception of ER, which is a key determinant. Thus, dietary intake is an important regulator of leptin production; however, the significance of these modest changes in diet-induced obese animals requires further study.

Authors+Show Affiliations

School of Dietetics and Human Nutrition, McGill University, MacDonald Campus, 21,111 Lakeshore Rd., Ste. Anne de Bellevue, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12562868

Citation

Hynes, Geoffrey R., et al. "Effects of Dietary Fat Type and Energy Restriction On Adipose Tissue Fatty Acid Composition and Leptin Production in Rats." Journal of Lipid Research, vol. 44, no. 5, 2003, pp. 893-901.
Hynes GR, Heshka J, Chadee K, et al. Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats. J Lipid Res. 2003;44(5):893-901.
Hynes, G. R., Heshka, J., Chadee, K., & Jones, P. J. (2003). Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats. Journal of Lipid Research, 44(5), 893-901.
Hynes GR, et al. Effects of Dietary Fat Type and Energy Restriction On Adipose Tissue Fatty Acid Composition and Leptin Production in Rats. J Lipid Res. 2003;44(5):893-901. PubMed PMID: 12562868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary fat type and energy restriction on adipose tissue fatty acid composition and leptin production in rats. AU - Hynes,Geoffrey R, AU - Heshka,Jode, AU - Chadee,Kris, AU - Jones,Peter J, Y1 - 2003/02/01/ PY - 2003/2/4/pubmed PY - 2004/1/24/medline PY - 2003/2/4/entrez SP - 893 EP - 901 JF - Journal of lipid research JO - J. Lipid Res. VL - 44 IS - 5 N2 - To investigate whether dietary fatty acid (FA) composition and energy restriction (ER) interactively influence obese (ob) gene expression, rats consumed diets containing beef tallow, safflower, or fish oil ad libitum (AL) or at 60% AL intake. Circulating leptin concentrations were higher (P < 0.0001) after AL feeding, but were not influenced by dietary fat. ER decreased (P < 0.0001) weight gain and visceral adipose weight, which were positively correlated (r = 0.40 P < 0.001, r = 0.58 P < 0.0001) with circulating leptin levels. Visceral adipose ob mRNA levels were greater in animals fed unsaturated fats, particularly safflower oil, which had the highest ob mRNA levels. Circulating leptin levels did not parallel ob mRNA levels, except for the greater abundance detected in AL adipose in comparison to ER animals. In addition, visceral FA profiles reflected dietary fat source and were influenced by an interaction of dietary fat and energy. These data demonstrate that dietary fat, particularly from a plant or marine source, and ER interactively influence ob mRNA levels; however, alterations in ob mRNA do not confer changes in circulating leptin, with the exception of ER, which is a key determinant. Thus, dietary intake is an important regulator of leptin production; however, the significance of these modest changes in diet-induced obese animals requires further study. SN - 0022-2275 UR - https://www.unboundmedicine.com/medline/citation/12562868/Effects_of_dietary_fat_type_and_energy_restriction_on_adipose_tissue_fatty_acid_composition_and_leptin_production_in_rats_ L2 - http://www.jlr.org/cgi/pmidlookup?view=long&amp;pmid=12562868 DB - PRIME DP - Unbound Medicine ER -