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HLA-B27 and its subtypes in 4 Taiwanese Aborigine tribes: a comparison to Han Chinese patients with ankylosing spondylitis.
J Rheumatol. 2003 Feb; 30(2):321-5.JR

Abstract

OBJECTIVE

We surveyed B27 and its subtypes in 5 ethnic groups in Taiwan.

METHODS

Blood was obtained from 281 Aborigine people of the Atayal tribe (I-Lan), 141 Paiwan (Ping-Ton), 38 Rukai (Ping-Ton), and 40 Yami (Orchid Island), and also 47 B27+ healthy Han Chinese subjects and 82 B27+ Han patients with ankylosing spondylitis (AS). HLA-B27 and its subtypes were determined by standard methods.

RESULTS

A much higher prevalence of B27 was found among the Atayal Aborigines (9.2%), which was significantly different from a lower prevalence in the Paiwan (2.1%; p = 0.004) and even higher than that of Han Chinese (5.59%; p = 0.04). No blood sample from the 38 Rukai Aborigines showed any B27. B2704 was the only subtype (100%) found in the 28 healthy Aborigines and 2 Aborigine patients with AS. However, in Chinese subjects, 40 of 47 (85%) B27+ healthy subjects were B2704, and 7 of 47 (15%) were B2705. In Chinese B27+ AS patients, 77 of 82 (94%) were B2704 and 5 of 82 (6%) were B2705. No other subtypes were found. Only the Aborigines without AS carrying B2704 showed a significant difference from the Chinese without AS carrying B2704 (p = 0.041).

CONCLUSION

The different prevalence of B27, but similar frequency of the B2704 subtype, between Aborigines and Han Chinese suggests Aborigines are a unique population and may originate from an Asian country, possibly mainland China.

Authors+Show Affiliations

Chou CT
Division of Allergy-Immunology-Rheumatology, Veterans General Hospital, Taipei, Taiwan. ctchou@vghtpe.gov.tw
Chen JM
No affiliation info available
Hsu CM
No affiliation info available
Chen SJ
No affiliation info available

MeSH

Asian PeopleGene FrequencyHLA-B27 AntigenHumansNative Hawaiian or Other Pacific IslanderRacial GroupsSpondylitis, AnkylosingTaiwan

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12563689

Citation

Chou, Chung T., et al. "HLA-B27 and Its Subtypes in 4 Taiwanese Aborigine Tribes: a Comparison to Han Chinese Patients With Ankylosing Spondylitis." The Journal of Rheumatology, vol. 30, no. 2, 2003, pp. 321-5.
Chou CT, Chen JM, Hsu CM, et al. HLA-B27 and its subtypes in 4 Taiwanese Aborigine tribes: a comparison to Han Chinese patients with ankylosing spondylitis. J Rheumatol. 2003;30(2):321-5.
Chou, C. T., Chen, J. M., Hsu, C. M., & Chen, S. J. (2003). HLA-B27 and its subtypes in 4 Taiwanese Aborigine tribes: a comparison to Han Chinese patients with ankylosing spondylitis. The Journal of Rheumatology, 30(2), 321-5.
Chou CT, et al. HLA-B27 and Its Subtypes in 4 Taiwanese Aborigine Tribes: a Comparison to Han Chinese Patients With Ankylosing Spondylitis. J Rheumatol. 2003;30(2):321-5. PubMed PMID: 12563689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-B27 and its subtypes in 4 Taiwanese Aborigine tribes: a comparison to Han Chinese patients with ankylosing spondylitis. AU - Chou,Chung T, AU - Chen,Jia M, AU - Hsu,Chang M, AU - Chen,Shu J, PY - 2003/2/4/pubmed PY - 2003/5/13/medline PY - 2003/2/4/entrez SP - 321 EP - 5 JF - The Journal of rheumatology JO - J Rheumatol VL - 30 IS - 2 N2 - OBJECTIVE: We surveyed B27 and its subtypes in 5 ethnic groups in Taiwan. METHODS: Blood was obtained from 281 Aborigine people of the Atayal tribe (I-Lan), 141 Paiwan (Ping-Ton), 38 Rukai (Ping-Ton), and 40 Yami (Orchid Island), and also 47 B27+ healthy Han Chinese subjects and 82 B27+ Han patients with ankylosing spondylitis (AS). HLA-B27 and its subtypes were determined by standard methods. RESULTS: A much higher prevalence of B27 was found among the Atayal Aborigines (9.2%), which was significantly different from a lower prevalence in the Paiwan (2.1%; p = 0.004) and even higher than that of Han Chinese (5.59%; p = 0.04). No blood sample from the 38 Rukai Aborigines showed any B27. B2704 was the only subtype (100%) found in the 28 healthy Aborigines and 2 Aborigine patients with AS. However, in Chinese subjects, 40 of 47 (85%) B27+ healthy subjects were B2704, and 7 of 47 (15%) were B2705. In Chinese B27+ AS patients, 77 of 82 (94%) were B2704 and 5 of 82 (6%) were B2705. No other subtypes were found. Only the Aborigines without AS carrying B2704 showed a significant difference from the Chinese without AS carrying B2704 (p = 0.041). CONCLUSION: The different prevalence of B27, but similar frequency of the B2704 subtype, between Aborigines and Han Chinese suggests Aborigines are a unique population and may originate from an Asian country, possibly mainland China. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/12563689/HLA_B27_and_its_subtypes_in_4_Taiwanese_Aborigine_tribes:_a_comparison_to_Han_Chinese_patients_with_ankylosing_spondylitis_ DB - PRIME DP - Unbound Medicine ER -