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Combined use of frequency doubling perimetry and polarimetric measurements of retinal nerve fiber layer in glaucoma detection.
Am J Ophthalmol. 2003 Feb; 135(2):160-8.AJ

Abstract

PURPOSE

The aim of this study was to evaluate the diagnostic usefulness of the combined use of frequency-doubling technology (FDT) perimetry and polarimetry of the retinal nerve fiber layer.

DESIGN

Cross-sectional study.

METHODS

Seventy ocular hypertensive patients (normal optic disk and standard perimetry, elevated intraocular pressure [>21 mm Hg]), 59 patients with "preperimetric" open-angle glaucoma (glaucomatous optic disk atrophy, elevated intraocular pressure [>21 mm Hg], no visual field defect in standard perimetry), 105 patients with "perimetric" open-angle glaucoma (glaucomatous optic disk atrophy and clearly marked visual field defect), and 73 control subjects had FDT screening (protocol: C-20-5) and polarimetric measurements (GDx). Criteria for exclusion: optic disks larger than 4 mm(2), media opacities, patients younger than 33 years or older than 66 years. None of the subjects had earlier FDT perimetry. One eye of each patient and control subject entered the statistical evaluation. Database and statistical software were used for case-wise recalculation of all missed localized probability levels to create a FDT screening score.

RESULTS

At a predefined specificity of 94.5% in control eyes, discrimination between "perimetric" glaucoma and normal subjects is superior using the FDT perimetry (sensitivity = 84.8%) in comparison to polarimetry (sensitivity = 63.8%), whereas sensitivity is similar with both methods in "preperimetric" patients (GDx, FDT: 25.4%). In several cases, patients classified as glaucomatous by the GDx are not the same patients as identified by the FDT perimetry. Therefore, a two-dimensional discrimination analysis can increase correct positive classification. Using a linear combination of the present FDT screening score and polarimetry ("the number"), 92.4% of "perimetric" glaucoma eyes and 44.1% of "preperimetric" glaucoma eyes have been classified as glaucomatous.

CONCLUSION

Joint usage of polarimetry and FDT perimetry indicate that a combination of different techniques which can uncover different glaucoma properties, might be helpful in early glaucoma detection.

Authors+Show Affiliations

Department of Ophthalmology and University Eye Hospital, Friedrich-Alexander University Erlangen-Nürnberg at Erlangen, Erlangen, Germany. folkert.horn@augen.imed.uni-erlangen.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12566019

Citation

Horn, Folkert K., et al. "Combined Use of Frequency Doubling Perimetry and Polarimetric Measurements of Retinal Nerve Fiber Layer in Glaucoma Detection." American Journal of Ophthalmology, vol. 135, no. 2, 2003, pp. 160-8.
Horn FK, Nguyen NX, Mardin CY, et al. Combined use of frequency doubling perimetry and polarimetric measurements of retinal nerve fiber layer in glaucoma detection. Am J Ophthalmol. 2003;135(2):160-8.
Horn, F. K., Nguyen, N. X., Mardin, C. Y., & Jünemann, A. G. (2003). Combined use of frequency doubling perimetry and polarimetric measurements of retinal nerve fiber layer in glaucoma detection. American Journal of Ophthalmology, 135(2), 160-8.
Horn FK, et al. Combined Use of Frequency Doubling Perimetry and Polarimetric Measurements of Retinal Nerve Fiber Layer in Glaucoma Detection. Am J Ophthalmol. 2003;135(2):160-8. PubMed PMID: 12566019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined use of frequency doubling perimetry and polarimetric measurements of retinal nerve fiber layer in glaucoma detection. AU - Horn,Folkert K, AU - Nguyen,Nhung X, AU - Mardin,Christian Y, AU - Jünemann,Anselm G, PY - 2003/2/5/pubmed PY - 2003/2/14/medline PY - 2003/2/5/entrez SP - 160 EP - 8 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 135 IS - 2 N2 - PURPOSE: The aim of this study was to evaluate the diagnostic usefulness of the combined use of frequency-doubling technology (FDT) perimetry and polarimetry of the retinal nerve fiber layer. DESIGN: Cross-sectional study. METHODS: Seventy ocular hypertensive patients (normal optic disk and standard perimetry, elevated intraocular pressure [>21 mm Hg]), 59 patients with "preperimetric" open-angle glaucoma (glaucomatous optic disk atrophy, elevated intraocular pressure [>21 mm Hg], no visual field defect in standard perimetry), 105 patients with "perimetric" open-angle glaucoma (glaucomatous optic disk atrophy and clearly marked visual field defect), and 73 control subjects had FDT screening (protocol: C-20-5) and polarimetric measurements (GDx). Criteria for exclusion: optic disks larger than 4 mm(2), media opacities, patients younger than 33 years or older than 66 years. None of the subjects had earlier FDT perimetry. One eye of each patient and control subject entered the statistical evaluation. Database and statistical software were used for case-wise recalculation of all missed localized probability levels to create a FDT screening score. RESULTS: At a predefined specificity of 94.5% in control eyes, discrimination between "perimetric" glaucoma and normal subjects is superior using the FDT perimetry (sensitivity = 84.8%) in comparison to polarimetry (sensitivity = 63.8%), whereas sensitivity is similar with both methods in "preperimetric" patients (GDx, FDT: 25.4%). In several cases, patients classified as glaucomatous by the GDx are not the same patients as identified by the FDT perimetry. Therefore, a two-dimensional discrimination analysis can increase correct positive classification. Using a linear combination of the present FDT screening score and polarimetry ("the number"), 92.4% of "perimetric" glaucoma eyes and 44.1% of "preperimetric" glaucoma eyes have been classified as glaucomatous. CONCLUSION: Joint usage of polarimetry and FDT perimetry indicate that a combination of different techniques which can uncover different glaucoma properties, might be helpful in early glaucoma detection. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/12566019/Combined_use_of_frequency_doubling_perimetry_and_polarimetric_measurements_of_retinal_nerve_fiber_layer_in_glaucoma_detection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939402019268 DB - PRIME DP - Unbound Medicine ER -