Tags

Type your tag names separated by a space and hit enter

Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease.
Am J Med. 2002 Dec 30; 113 Suppl 9B:13S-24S.AJ

Abstract

Several dietary approaches have reduced cardiovascular events in randomized clinical trials. Replacing saturated fat with polyunsaturated fat prevented coronary events in men, and a Mediterranean diet and fatty fish improved survival. None of these trials had much impact on total fat intake but rather increased vegetable oils, n-3 fatty acids, or many other plant foods or nutrients that are linked to coronary prevention. The reductions in cardiovascular disease (CVD) caused by these dietary therapies compare favorably with drug treatments for hyperlipidemia and hypertension. Improvement in blood lipid risk factors is an important mechanism to explain the results of trials of unsaturated fats. When saturated or trans unsaturated fats are replaced with monounsaturated or n-6 polyunsaturated fats from vegetable oils, primarily low-density lipoprotein (LDL) cholesterol decreases. The LDL to high-density lipoprotein (HDL) cholesterol ratio decreases. When carbohydrates are used to replace saturated fats, in a low-fat diet, LDL and HDL decrease similarly, and the ratio is not improved; triglycerides increase as well when carbohydrate increases, except when low glycemic index foods are used. The n-3 polyunsaturated fats in fish oils suppress cardiac arrhythmias and reduce triglycerides, but they have little effect on LDL or HDL cholesterol levels. The theme should be that diet has benefits that come directly from foods, as well as from the reduction in saturated fats, cholesterol, meats, and fatty dairy foods. It is likely that many diets could be designed that could prevent CVD. This potential diversity is crucial for engaging the diverse cultures and tastes of people worldwide in cardiovascular disease prevention.

Authors+Show Affiliations

Nutrition Department, Harvard School of Public Health, (FMS), Boston, Massachusetts 02115, USA. fsacks@hsph.harvard.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12566134

Citation

Sacks, Frank M., and Martijn Katan. "Randomized Clinical Trials On the Effects of Dietary Fat and Carbohydrate On Plasma Lipoproteins and Cardiovascular Disease." The American Journal of Medicine, vol. 113 Suppl 9B, 2002, 13S-24S.
Sacks FM, Katan M. Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. Am J Med. 2002;113 Suppl 9B:13S-24S.
Sacks, F. M., & Katan, M. (2002). Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. The American Journal of Medicine, 113 Suppl 9B, 13S-24S.
Sacks FM, Katan M. Randomized Clinical Trials On the Effects of Dietary Fat and Carbohydrate On Plasma Lipoproteins and Cardiovascular Disease. Am J Med. 2002 Dec 30;113 Suppl 9B:13S-24S. PubMed PMID: 12566134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. AU - Sacks,Frank M, AU - Katan,Martijn, PY - 2003/2/5/pubmed PY - 2003/2/26/medline PY - 2003/2/5/entrez SP - 13S EP - 24S JF - The American journal of medicine JO - Am J Med VL - 113 Suppl 9B N2 - Several dietary approaches have reduced cardiovascular events in randomized clinical trials. Replacing saturated fat with polyunsaturated fat prevented coronary events in men, and a Mediterranean diet and fatty fish improved survival. None of these trials had much impact on total fat intake but rather increased vegetable oils, n-3 fatty acids, or many other plant foods or nutrients that are linked to coronary prevention. The reductions in cardiovascular disease (CVD) caused by these dietary therapies compare favorably with drug treatments for hyperlipidemia and hypertension. Improvement in blood lipid risk factors is an important mechanism to explain the results of trials of unsaturated fats. When saturated or trans unsaturated fats are replaced with monounsaturated or n-6 polyunsaturated fats from vegetable oils, primarily low-density lipoprotein (LDL) cholesterol decreases. The LDL to high-density lipoprotein (HDL) cholesterol ratio decreases. When carbohydrates are used to replace saturated fats, in a low-fat diet, LDL and HDL decrease similarly, and the ratio is not improved; triglycerides increase as well when carbohydrate increases, except when low glycemic index foods are used. The n-3 polyunsaturated fats in fish oils suppress cardiac arrhythmias and reduce triglycerides, but they have little effect on LDL or HDL cholesterol levels. The theme should be that diet has benefits that come directly from foods, as well as from the reduction in saturated fats, cholesterol, meats, and fatty dairy foods. It is likely that many diets could be designed that could prevent CVD. This potential diversity is crucial for engaging the diverse cultures and tastes of people worldwide in cardiovascular disease prevention. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/12566134/Randomized_clinical_trials_on_the_effects_of_dietary_fat_and_carbohydrate_on_plasma_lipoproteins_and_cardiovascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002934301009871 DB - PRIME DP - Unbound Medicine ER -