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Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism.
Gynecol Obstet Invest. 2002; 54(2):105-8.GO

Abstract

OBJECTIVE

To compare the clinical, hormonal, biochemical and hemotological effects of flutamide versus flutamide plus an oral contraceptive (OC) in the treatment of hirsutism.

PATIENTS

Eighty-four women with hirsutism were equally randomized to receive either flutamide or flutamide plus OC.

DESIGN

Eighty-four women with hirsutism were recruited from patients presenting to our hospital. Each patient underwent a complete medical and gynecological examination as well as blood cell counts, biochemical and endocrine profiles. Hirsutism scores and laboratory tests were done during the 1st, 3rd and 6th months of therapy. Thirty-seven women in the flutamide group (taking 250 mg flutamide per day) and 32 women in the flutamide plus OC group (taking 250 mg flutamide plus 35 microg ethinyl estradiol and 2 mg cyproterone acetate per day) regularly followed the therapy regimens.

RESULTS

There were no significant differences in Ferriman-Gallway scores at the beginning and at the end of the therapies between the two groups (p > 0.05). At the 6th month, the decreases in Ferriman-Gallway scores were significant in both flutamide (from 18.95 +/- 4.44 to 14.46 +/- 5.02; p < 0.05) and flutamide plus OC groups (from 19.94 +/- 4.31 to 15.58 +/- 4.28; p < 0.05). In the first group, 2 of 6 oligomenorrheic women had regular cycles at the end of the therapy. Oligomenorrhea in 8 women was all changed to regular cycles in the flutamide plus OC group. Regarding the hormonal profile, only in the second group were prolactin, free testosterone and dehydroepiandrosterone sulfate levels significantly decreased (p < 0.05). Hepatic function tests were significantly increased in both groups, but they were all within normal ranges.

CONCLUSION

These data suggest that both therapies were similarly effective and safe in the treatment of hirsutism. In women with oligomenorrhea and/or needing contraception, adding an OC shows better results than flutamide treatment alone in providing regular cycles.

Authors+Show Affiliations

Taner C
SSK Aegean Maternity Hospital, Izmir, Turkey. cuneyt_taner@hotmail.com
Inal M
No affiliation info available
Başogul O
No affiliation info available
Onoglu A
No affiliation info available
Karanfil C
No affiliation info available
Tinar S
No affiliation info available
Ispahi C
No affiliation info available

MeSH

Administration, OralAdultAndrogen AntagonistsContraceptives, OralCyproterone AcetateDehydroepiandrosterone SulfateDrug Administration ScheduleDrug Therapy, CombinationEthinyl EstradiolFemaleFlutamideHirsutismHumansLiver Function TestsProlactinSeverity of Illness IndexTestosteroneTreatment Outcome

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12566753

Citation

Taner, Cüneyt, et al. "Comparison of the Clinical Efficacy and Safety of Flutamide Versus Flutamide Plus an Oral Contraceptive in the Treatment of Hirsutism." Gynecologic and Obstetric Investigation, vol. 54, no. 2, 2002, pp. 105-8.
Taner C, Inal M, Başogul O, et al. Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism. Gynecol Obstet Invest. 2002;54(2):105-8.
Taner, C., Inal, M., Başogul, O., Onoglu, A., Karanfil, C., Tinar, S., & Ispahi, C. (2002). Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism. Gynecologic and Obstetric Investigation, 54(2), 105-8.
Taner C, et al. Comparison of the Clinical Efficacy and Safety of Flutamide Versus Flutamide Plus an Oral Contraceptive in the Treatment of Hirsutism. Gynecol Obstet Invest. 2002;54(2):105-8. PubMed PMID: 12566753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism. AU - Taner,Cüneyt, AU - Inal,Murat, AU - Başogul,Omer, AU - Onoglu,Ahmet, AU - Karanfil,Cemal, AU - Tinar,Sivekar, AU - Ispahi,Cigdem, PY - 2002/02/06/received PY - 2003/2/5/pubmed PY - 2003/4/11/medline PY - 2003/2/5/entrez SP - 105 EP - 8 JF - Gynecologic and obstetric investigation JO - Gynecol Obstet Invest VL - 54 IS - 2 N2 - OBJECTIVE: To compare the clinical, hormonal, biochemical and hemotological effects of flutamide versus flutamide plus an oral contraceptive (OC) in the treatment of hirsutism. PATIENTS: Eighty-four women with hirsutism were equally randomized to receive either flutamide or flutamide plus OC. DESIGN: Eighty-four women with hirsutism were recruited from patients presenting to our hospital. Each patient underwent a complete medical and gynecological examination as well as blood cell counts, biochemical and endocrine profiles. Hirsutism scores and laboratory tests were done during the 1st, 3rd and 6th months of therapy. Thirty-seven women in the flutamide group (taking 250 mg flutamide per day) and 32 women in the flutamide plus OC group (taking 250 mg flutamide plus 35 microg ethinyl estradiol and 2 mg cyproterone acetate per day) regularly followed the therapy regimens. RESULTS: There were no significant differences in Ferriman-Gallway scores at the beginning and at the end of the therapies between the two groups (p > 0.05). At the 6th month, the decreases in Ferriman-Gallway scores were significant in both flutamide (from 18.95 +/- 4.44 to 14.46 +/- 5.02; p < 0.05) and flutamide plus OC groups (from 19.94 +/- 4.31 to 15.58 +/- 4.28; p < 0.05). In the first group, 2 of 6 oligomenorrheic women had regular cycles at the end of the therapy. Oligomenorrhea in 8 women was all changed to regular cycles in the flutamide plus OC group. Regarding the hormonal profile, only in the second group were prolactin, free testosterone and dehydroepiandrosterone sulfate levels significantly decreased (p < 0.05). Hepatic function tests were significantly increased in both groups, but they were all within normal ranges. CONCLUSION: These data suggest that both therapies were similarly effective and safe in the treatment of hirsutism. In women with oligomenorrhea and/or needing contraception, adding an OC shows better results than flutamide treatment alone in providing regular cycles. SN - 0378-7346 UR - https://www.unboundmedicine.com/medline/citation/12566753/Comparison_of_the_clinical_efficacy_and_safety_of_flutamide_versus_flutamide_plus_an_oral_contraceptive_in_the_treatment_of_hirsutism_ DB - PRIME DP - Unbound Medicine ER -