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Effects of sildenafil citrate (Viagra) on choroidal congestion.
Ophthalmologica. 2002 Nov-Dec; 216(6):455-8.O

Abstract

This study evaluates the effect of sildenafil on choroidal vascular congestion and its correlation with visual effects. Thirteen healthy subjects were randomized to a sildenafil group (n = 7, 3 M, 4 F), who received 200 mg of sildenafil, and a control (n = 6, 5 F, 1 M) group, who received no drug. Measurements of choroidal thickness with ultrasonography, color vision with Desaturated Panel D-15 Test, and contrast sensitivity with CSV-1000e charts (Vector Vision) were performed at baseline and at 90 and 180 min. Mean choroidal thickness and contrast sensitivity did not change significantly relative to baseline in either group. However, the variance in differences between repeat and baseline measurements of choroidal thickness was significantly higher at 90 min (p = 0.003) in the sildenafil subjects. Color discrimination error scores increased after sildenafil but did not correlate with changes in choroidal thickness. An oral dose of 200 mg of sildenafil caused small inconsistent changes in choroidal thickness, which did not correlate with visual effects.

Authors+Show Affiliations

The University of California, Irvine, Department of Ophthalmology, Irvine, Calif 92697-4375, USA. tmcculle@uci.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12566892

Citation

McCulley, Timothy J., et al. "Effects of Sildenafil Citrate (Viagra) On Choroidal Congestion." Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, vol. 216, no. 6, 2002, pp. 455-8.
McCulley TJ, Luu JK, Marmor MF, et al. Effects of sildenafil citrate (Viagra) on choroidal congestion. Ophthalmologica. 2002;216(6):455-8.
McCulley, T. J., Luu, J. K., Marmor, M. F., & Feuer, W. J. (2002). Effects of sildenafil citrate (Viagra) on choroidal congestion. Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde, 216(6), 455-8.
McCulley TJ, et al. Effects of Sildenafil Citrate (Viagra) On Choroidal Congestion. Ophthalmologica. 2002 Nov-Dec;216(6):455-8. PubMed PMID: 12566892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of sildenafil citrate (Viagra) on choroidal congestion. AU - McCulley,Timothy J, AU - Luu,James K, AU - Marmor,Michael F, AU - Feuer,William J, PY - 2002/04/12/received PY - 2003/2/5/pubmed PY - 2003/3/7/medline PY - 2003/2/5/entrez SP - 455 EP - 8 JF - Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde JO - Ophthalmologica VL - 216 IS - 6 N2 - This study evaluates the effect of sildenafil on choroidal vascular congestion and its correlation with visual effects. Thirteen healthy subjects were randomized to a sildenafil group (n = 7, 3 M, 4 F), who received 200 mg of sildenafil, and a control (n = 6, 5 F, 1 M) group, who received no drug. Measurements of choroidal thickness with ultrasonography, color vision with Desaturated Panel D-15 Test, and contrast sensitivity with CSV-1000e charts (Vector Vision) were performed at baseline and at 90 and 180 min. Mean choroidal thickness and contrast sensitivity did not change significantly relative to baseline in either group. However, the variance in differences between repeat and baseline measurements of choroidal thickness was significantly higher at 90 min (p = 0.003) in the sildenafil subjects. Color discrimination error scores increased after sildenafil but did not correlate with changes in choroidal thickness. An oral dose of 200 mg of sildenafil caused small inconsistent changes in choroidal thickness, which did not correlate with visual effects. SN - 0030-3755 UR - https://www.unboundmedicine.com/medline/citation/12566892/Effects_of_sildenafil_citrate__Viagra__on_choroidal_congestion_ L2 - https://www.karger.com?DOI=10.1159/000067549 DB - PRIME DP - Unbound Medicine ER -