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Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with hepatitis C virus and human immunodeficiency virus.
Clin Infect Dis. 2003 Feb 15; 36(4):491-8.CI

Abstract

To evaluate the factors associated with the evolution of chronic hepatitis C in human immunodeficiency virus (HIV)-infected patients, a cross-sectional analysis of 41 HIV-infected patients with chronic hepatitis C (known as "HIV-HCV [hepatitis C virus]-coinfected patients") and a control group of patients with chronic hepatitis C who did not have HIV infection (known as "non-HIV-infected patients") was performed. The association of histological variables with demographic parameters, HCV load and genotype, HIV load, CD4(+) T cell count, and response to highly active antiretroviral therapy (HAART) was evaluated. HIV-HCV-coinfected patients showed a significantly higher HCV load, more-advanced fibrosis, and a higher liver fibrosis progression rate (FPR) than did non-HIV-infected patients. A high HCV load and a low CD4(+) T cell count were associated with a higher FPR. The immune response induced by HAART did not influence this progression. In conclusion, HIV-HCV-infected patients, mainly such patients with a high HCV load and an immunodepressed state, have a higher FPR. An independent effect of the immune response to HAART was not evident.

Authors+Show Affiliations

Gastroenterology Unit, Hospital Universitario Puerta del Mar, Cádiz, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12567308

Citation

Martinez-Sierra, Carmen, et al. "Progression of Chronic Hepatitis C to Liver Fibrosis and Cirrhosis in Patients Coinfected With Hepatitis C Virus and Human Immunodeficiency Virus." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 36, no. 4, 2003, pp. 491-8.
Martinez-Sierra C, Arizcorreta A, Díaz F, et al. Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with hepatitis C virus and human immunodeficiency virus. Clin Infect Dis. 2003;36(4):491-8.
Martinez-Sierra, C., Arizcorreta, A., Díaz, F., Roldán, R., Martín-Herrera, L., Pérez-Guzmán, E., & Girón-González, J. A. (2003). Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with hepatitis C virus and human immunodeficiency virus. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 36(4), 491-8.
Martinez-Sierra C, et al. Progression of Chronic Hepatitis C to Liver Fibrosis and Cirrhosis in Patients Coinfected With Hepatitis C Virus and Human Immunodeficiency Virus. Clin Infect Dis. 2003 Feb 15;36(4):491-8. PubMed PMID: 12567308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with hepatitis C virus and human immunodeficiency virus. AU - Martinez-Sierra,Carmen, AU - Arizcorreta,Ana, AU - Díaz,Fernando, AU - Roldán,Rafael, AU - Martín-Herrera,Leopoldo, AU - Pérez-Guzmán,Eugenio, AU - Girón-González,José A, Y1 - 2003/01/31/ PY - 2002/09/11/received PY - 2002/11/18/accepted PY - 2003/2/5/pubmed PY - 2003/2/22/medline PY - 2003/2/5/entrez SP - 491 EP - 8 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 36 IS - 4 N2 - To evaluate the factors associated with the evolution of chronic hepatitis C in human immunodeficiency virus (HIV)-infected patients, a cross-sectional analysis of 41 HIV-infected patients with chronic hepatitis C (known as "HIV-HCV [hepatitis C virus]-coinfected patients") and a control group of patients with chronic hepatitis C who did not have HIV infection (known as "non-HIV-infected patients") was performed. The association of histological variables with demographic parameters, HCV load and genotype, HIV load, CD4(+) T cell count, and response to highly active antiretroviral therapy (HAART) was evaluated. HIV-HCV-coinfected patients showed a significantly higher HCV load, more-advanced fibrosis, and a higher liver fibrosis progression rate (FPR) than did non-HIV-infected patients. A high HCV load and a low CD4(+) T cell count were associated with a higher FPR. The immune response induced by HAART did not influence this progression. In conclusion, HIV-HCV-infected patients, mainly such patients with a high HCV load and an immunodepressed state, have a higher FPR. An independent effect of the immune response to HAART was not evident. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/12567308/Progression_of_chronic_hepatitis_C_to_liver_fibrosis_and_cirrhosis_in_patients_coinfected_with_hepatitis_C_virus_and_human_immunodeficiency_virus_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/367643 DB - PRIME DP - Unbound Medicine ER -