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[Excretion ratio of lactulose and mannitol as intestinal permeability index in healthy Chinese volunteers].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999 Oct; 21(5):407-11.ZY

Abstract

OBJECTIVE

To determine lactulose (L)/mannitol (M) excretion ratio with high pressure liquid chromatograph with pulsed electrochemical detection (HPLC-PED) in healthy Chinese volunteers.

METHODS

Sixty healthy Chinese volunteers enrolled. For each volunteer the L/M permeability study was performed twice by two different doses, as small dose (1 g mannitol and 2 g lactulose) and regular dose (5 g mannitol and 10 g lactulose). The urine were collected during 6 hours after ingestion of the test solution. The M and L concentrations were analyzed by HPLC with pulsed electrochemical detection.

RESULTS

The L/M ratio was 0.026 +/- 0.006 in the small doses tests, and 0.036 +/- 0.008 in the large doses tests.

CONCLUSIONS

With HPLC-PED detection, a low doses of lactulose and mannitol can be used to study intestinal permeability. Determination of the L/M ratio may be a way of evaluating intestinal barrier function in clinical practice.

Authors+Show Affiliations

Department of Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12567442

Citation

Liu, W, et al. "[Excretion Ratio of Lactulose and Mannitol as Intestinal Permeability Index in Healthy Chinese Volunteers]." Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 21, no. 5, 1999, pp. 407-11.
Liu W, Jiang Z, Shu H, et al. [Excretion ratio of lactulose and mannitol as intestinal permeability index in healthy Chinese volunteers]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999;21(5):407-11.
Liu, W., Jiang, Z., Shu, H., Sun, M., & Li, D. (1999). [Excretion ratio of lactulose and mannitol as intestinal permeability index in healthy Chinese volunteers]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 21(5), 407-11.
Liu W, et al. [Excretion Ratio of Lactulose and Mannitol as Intestinal Permeability Index in Healthy Chinese Volunteers]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1999;21(5):407-11. PubMed PMID: 12567442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Excretion ratio of lactulose and mannitol as intestinal permeability index in healthy Chinese volunteers]. AU - Liu,W, AU - Jiang,Z, AU - Shu,H, AU - Sun,M, AU - Li,D, PY - 2003/2/6/pubmed PY - 2003/10/8/medline PY - 2003/2/6/entrez SP - 407 EP - 11 JF - Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae JO - Zhongguo Yi Xue Ke Xue Yuan Xue Bao VL - 21 IS - 5 N2 - OBJECTIVE: To determine lactulose (L)/mannitol (M) excretion ratio with high pressure liquid chromatograph with pulsed electrochemical detection (HPLC-PED) in healthy Chinese volunteers. METHODS: Sixty healthy Chinese volunteers enrolled. For each volunteer the L/M permeability study was performed twice by two different doses, as small dose (1 g mannitol and 2 g lactulose) and regular dose (5 g mannitol and 10 g lactulose). The urine were collected during 6 hours after ingestion of the test solution. The M and L concentrations were analyzed by HPLC with pulsed electrochemical detection. RESULTS: The L/M ratio was 0.026 +/- 0.006 in the small doses tests, and 0.036 +/- 0.008 in the large doses tests. CONCLUSIONS: With HPLC-PED detection, a low doses of lactulose and mannitol can be used to study intestinal permeability. Determination of the L/M ratio may be a way of evaluating intestinal barrier function in clinical practice. SN - 1000-503X UR - https://www.unboundmedicine.com/medline/citation/12567442/[Excretion_ratio_of_lactulose_and_mannitol_as_intestinal_permeability_index_in_healthy_Chinese_volunteers]_ DB - PRIME DP - Unbound Medicine ER -
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