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[Preparation of diltiazem hydrochloride delayed-onset, sustained release tablet].
Yao Xue Xue Bao. 2002 Sep; 37(9):724-7.YX

Abstract

AIM

To prepare dilitazem hydrochloride delayed-onset, sustained release tablet, which can not only provide the delay in release start, but also the constant release rate after a lag time. To analyze release mechanism and investigate the effect of outershell compositions on release behavior.

METHODS

The delayed-onset, sustained release tablets were prepared by dry-compression coated technology. The release profiles of uncoated cores and presscoated tablets were compared. Two parameters, time-lag (Tlag) and release rate (k), were used to evaluate the influence of factors, such as the amount of hydroxypropylmethylcellulose (HPMC) and poly-vinyl-pyrrolidinone (PVP) K30, the viscosity of ethylcellulose (EC) and HPMC, and the compression load on diltazam hydrochloride (DIL) release. Higuchi equation and Peppa's equation were used to analyze release mechanism.

RESULTS

With the increase of HPMC amount or HPMC viscosity, Tlag was prolonged and k was decreased; With the increase of PVP K30 amount, Tlag was shortened and k was increased; EC viscosity and compression load above certain degree showed no effect on DIL release.

CONCLUSION

The drug release from delayed-release tablet is controlled by erosion mechanism, Tlag is determined by the erosion rate of outer-shell.

Authors+Show Affiliations

Zhongkun Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210009, China.No affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

12567900

Citation

Zhang, Ning, and Jia-bi Zhu. "[Preparation of Diltiazem Hydrochloride Delayed-onset, Sustained Release Tablet]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 37, no. 9, 2002, pp. 724-7.
Zhang N, Zhu JB. [Preparation of diltiazem hydrochloride delayed-onset, sustained release tablet]. Yao Xue Xue Bao. 2002;37(9):724-7.
Zhang, N., & Zhu, J. B. (2002). [Preparation of diltiazem hydrochloride delayed-onset, sustained release tablet]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 37(9), 724-7.
Zhang N, Zhu JB. [Preparation of Diltiazem Hydrochloride Delayed-onset, Sustained Release Tablet]. Yao Xue Xue Bao. 2002;37(9):724-7. PubMed PMID: 12567900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Preparation of diltiazem hydrochloride delayed-onset, sustained release tablet]. AU - Zhang,Ning, AU - Zhu,Jia-bi, PY - 2003/2/6/pubmed PY - 2004/5/28/medline PY - 2003/2/6/entrez SP - 724 EP - 7 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 37 IS - 9 N2 - AIM: To prepare dilitazem hydrochloride delayed-onset, sustained release tablet, which can not only provide the delay in release start, but also the constant release rate after a lag time. To analyze release mechanism and investigate the effect of outershell compositions on release behavior. METHODS: The delayed-onset, sustained release tablets were prepared by dry-compression coated technology. The release profiles of uncoated cores and presscoated tablets were compared. Two parameters, time-lag (Tlag) and release rate (k), were used to evaluate the influence of factors, such as the amount of hydroxypropylmethylcellulose (HPMC) and poly-vinyl-pyrrolidinone (PVP) K30, the viscosity of ethylcellulose (EC) and HPMC, and the compression load on diltazam hydrochloride (DIL) release. Higuchi equation and Peppa's equation were used to analyze release mechanism. RESULTS: With the increase of HPMC amount or HPMC viscosity, Tlag was prolonged and k was decreased; With the increase of PVP K30 amount, Tlag was shortened and k was increased; EC viscosity and compression load above certain degree showed no effect on DIL release. CONCLUSION: The drug release from delayed-release tablet is controlled by erosion mechanism, Tlag is determined by the erosion rate of outer-shell. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/12567900/[Preparation_of_diltiazem_hydrochloride_delayed_onset_sustained_release_tablet]_ DB - PRIME DP - Unbound Medicine ER -