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Carbohydrate-energy restriction may protect the rat brain against oxidative damage and improve physical performance.
Br J Nutr. 2003 Jan; 89(1):89-96.BJ

Abstract

Chronic energy restriction, alpha-tocopherol supplementation and their interaction with exhaustive exercise were investigated. Eleven-week-old male Wistar rats (n 6x 10) were fed either a control (C), a 30 % carbohydrate-energy-restricted control (R) or an alpha-tocopherol-supplemented (S) diet for 5 months. The animals in each diet were divided into exercised (E) and non-exercised (NE) groups. Before killing, the exercised rats were required to run to exhaustion (39 (se 6), 69 (se 11) and 18 (se 2) min for the C, R and S groups, respectively). Lipid peroxidation (thiobarbituric acid-reactive substances; TBARS), protein damage (reactive carbonyls) and alpha-tocopherol were determined in gastrocnemius, liver, brain and/or plasma. There was no difference in lipid peroxidation between the R and C groups, but in liver and muscle peroxidation appeared significantly lower in the S than the other two diets. TBARS in the brain were similar in all groups. On the other hand, reactive carbonyls showed that both the R and S diets reduced protein damage in the brain, while exhaustive exercise increased it. For liver and muscle, however, reactive carbonyl levels were similar in all groups. alpha-Tocopherol supplementation increased the vitamin concentrations in liver, muscle and plasma, but exercise decreased them in plasma and brain. Carbohydrate-energy restriction increased (P=0.0025) resistance to exhaustive exercise considerably without depleting stores of alpha-tocopherol or exacerbating oxidative damage in monitored tissues. It is concluded that while exhaustive exercise promotes a tissue-specific oxidative damage detectable only in brain proteins, both experimental diets tended to ameliorate this condition.

Authors+Show Affiliations

Department of Nutrition, Federal University of Alagoas, Maceió, AL, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12568668

Citation

de Oliveira, S L., et al. "Carbohydrate-energy Restriction May Protect the Rat Brain Against Oxidative Damage and Improve Physical Performance." The British Journal of Nutrition, vol. 89, no. 1, 2003, pp. 89-96.
de Oliveira SL, Diniz DB, Amaya-Farfan J. Carbohydrate-energy restriction may protect the rat brain against oxidative damage and improve physical performance. Br J Nutr. 2003;89(1):89-96.
de Oliveira, S. L., Diniz, D. B., & Amaya-Farfan, J. (2003). Carbohydrate-energy restriction may protect the rat brain against oxidative damage and improve physical performance. The British Journal of Nutrition, 89(1), 89-96.
de Oliveira SL, Diniz DB, Amaya-Farfan J. Carbohydrate-energy Restriction May Protect the Rat Brain Against Oxidative Damage and Improve Physical Performance. Br J Nutr. 2003;89(1):89-96. PubMed PMID: 12568668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbohydrate-energy restriction may protect the rat brain against oxidative damage and improve physical performance. AU - de Oliveira,S L, AU - Diniz,D B, AU - Amaya-Farfan,J, PY - 2003/2/6/pubmed PY - 2003/2/21/medline PY - 2003/2/6/entrez SP - 89 EP - 96 JF - The British journal of nutrition JO - Br J Nutr VL - 89 IS - 1 N2 - Chronic energy restriction, alpha-tocopherol supplementation and their interaction with exhaustive exercise were investigated. Eleven-week-old male Wistar rats (n 6x 10) were fed either a control (C), a 30 % carbohydrate-energy-restricted control (R) or an alpha-tocopherol-supplemented (S) diet for 5 months. The animals in each diet were divided into exercised (E) and non-exercised (NE) groups. Before killing, the exercised rats were required to run to exhaustion (39 (se 6), 69 (se 11) and 18 (se 2) min for the C, R and S groups, respectively). Lipid peroxidation (thiobarbituric acid-reactive substances; TBARS), protein damage (reactive carbonyls) and alpha-tocopherol were determined in gastrocnemius, liver, brain and/or plasma. There was no difference in lipid peroxidation between the R and C groups, but in liver and muscle peroxidation appeared significantly lower in the S than the other two diets. TBARS in the brain were similar in all groups. On the other hand, reactive carbonyls showed that both the R and S diets reduced protein damage in the brain, while exhaustive exercise increased it. For liver and muscle, however, reactive carbonyl levels were similar in all groups. alpha-Tocopherol supplementation increased the vitamin concentrations in liver, muscle and plasma, but exercise decreased them in plasma and brain. Carbohydrate-energy restriction increased (P=0.0025) resistance to exhaustive exercise considerably without depleting stores of alpha-tocopherol or exacerbating oxidative damage in monitored tissues. It is concluded that while exhaustive exercise promotes a tissue-specific oxidative damage detectable only in brain proteins, both experimental diets tended to ameliorate this condition. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/12568668/Carbohydrate_energy_restriction_may_protect_the_rat_brain_against_oxidative_damage_and_improve_physical_performance_ L2 - https://www.cambridge.org/core/product/identifier/S0007114503000114/type/journal_article DB - PRIME DP - Unbound Medicine ER -