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Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics.
Am J Physiol Endocrinol Metab. 2003 May; 284(5):E1022-6.AJ

Abstract

To quantitatively evaluate the effect of insulin on cardiac sympathetic nerve activity (SNA) and analyze clinical factors associated with insulin sensitivity for the regulation of SNA in diabetics, 29 Japanese type 2 diabetics without neuropathy were recruited. A 2-h control study and a 2-h hyperinsulinemic euglycemic glucose clamp study were performed. From the power spectral analysis of R-R intervals on ECG during both studies, two major components, the low-frequency (LF) and the high-frequency component (HF), were obtained. Then %LF was calculated as LF/(LF +HF), and the ratio of the average %LF during the last 30 min of the clamp or the control to the average %LF for the entire time for clamp or control (R-%LF) was used as a marker of changes in SNA. R-%LF was significantly higher during the clamp than in the control (1.07 +/- 0.04 vs. 1.03 +/- 0.03, P < 0.05). High responders (individual R-%LF during clamp > or = mean + 2SD in control) showed a higher basal mean blood pressure (BP) before the clamp (89 +/- 3 vs. 82 +/- 2, P < 0.03) but not a higher glucose infusion rate (GIR) compared with low responders (<mean + 2SD). Furthermore, R-%LF showed a positive correlation with basal mean BP (P < 0.02) but not with GIR. These data demonstrate that an acute insulin load stimulates cardiac SNA, and insulin sensitivity in the regulation of SNA may be associated with BP regulation independently of peripheral insulin sensitivity.

Authors+Show Affiliations

Department of Medicine, Metabolism, and Endocrinology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12569084

Citation

Takagi, Miki, et al. "Responsiveness of Insulin-induced Cardiac Sympathetic Nerve Activation Associates With Blood Pressure Regulation in Diabetics." American Journal of Physiology. Endocrinology and Metabolism, vol. 284, no. 5, 2003, pp. E1022-6.
Takagi M, Tanaka Y, Yamasaki Y, et al. Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics. Am J Physiol Endocrinol Metab. 2003;284(5):E1022-6.
Takagi, M., Tanaka, Y., Yamasaki, Y., Yamamoto, M., Hori, M., Nakaniwa, T., Niwa, M., Uchino, H., Tamura, Y., Nomiyama, T., Watada, H., & Kawamori, R. (2003). Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics. American Journal of Physiology. Endocrinology and Metabolism, 284(5), E1022-6.
Takagi M, et al. Responsiveness of Insulin-induced Cardiac Sympathetic Nerve Activation Associates With Blood Pressure Regulation in Diabetics. Am J Physiol Endocrinol Metab. 2003;284(5):E1022-6. PubMed PMID: 12569084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics. AU - Takagi,Miki, AU - Tanaka,Yasushi, AU - Yamasaki,Yoshimitsu, AU - Yamamoto,Masahiko, AU - Hori,Masatsugu, AU - Nakaniwa,Tomiko, AU - Niwa,Masataka, AU - Uchino,Hiroshi, AU - Tamura,Yoshifumi, AU - Nomiyama,Takashi, AU - Watada,Hirotaka, AU - Kawamori,Ryuzo, Y1 - 2003/02/04/ PY - 2003/2/6/pubmed PY - 2003/5/22/medline PY - 2003/2/6/entrez SP - E1022 EP - 6 JF - American journal of physiology. Endocrinology and metabolism JO - Am J Physiol Endocrinol Metab VL - 284 IS - 5 N2 - To quantitatively evaluate the effect of insulin on cardiac sympathetic nerve activity (SNA) and analyze clinical factors associated with insulin sensitivity for the regulation of SNA in diabetics, 29 Japanese type 2 diabetics without neuropathy were recruited. A 2-h control study and a 2-h hyperinsulinemic euglycemic glucose clamp study were performed. From the power spectral analysis of R-R intervals on ECG during both studies, two major components, the low-frequency (LF) and the high-frequency component (HF), were obtained. Then %LF was calculated as LF/(LF +HF), and the ratio of the average %LF during the last 30 min of the clamp or the control to the average %LF for the entire time for clamp or control (R-%LF) was used as a marker of changes in SNA. R-%LF was significantly higher during the clamp than in the control (1.07 +/- 0.04 vs. 1.03 +/- 0.03, P < 0.05). High responders (individual R-%LF during clamp > or = mean + 2SD in control) showed a higher basal mean blood pressure (BP) before the clamp (89 +/- 3 vs. 82 +/- 2, P < 0.03) but not a higher glucose infusion rate (GIR) compared with low responders (<mean + 2SD). Furthermore, R-%LF showed a positive correlation with basal mean BP (P < 0.02) but not with GIR. These data demonstrate that an acute insulin load stimulates cardiac SNA, and insulin sensitivity in the regulation of SNA may be associated with BP regulation independently of peripheral insulin sensitivity. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/12569084/Responsiveness_of_insulin_induced_cardiac_sympathetic_nerve_activation_associates_with_blood_pressure_regulation_in_diabetics_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.00169.2002?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -