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Effect of water polo practice on cytokines, growth mediators, and leukocytes in girls.

Abstract

PURPOSE

The effects of exercise on growth and development are mediated through a complex interaction between the endocrine, immune, and nervous systems. Very little is known about how these systems respond to exercise in children or adolescents. Moreover, there are few studies that have examined growth factors, inflammatory cytokines, and leukocyte responses to "real-life" or field exercise solely in girls. Thus, the goal of the present study was to determine the acute exercise-induced alterations in the growth hormone --> insulin-like growth factor-I axis, inflammatory cytokines, and certain aspects of immune function in a group of adolescent girls after a typical water polo practice.

METHODS

Ten, healthy, high-school female subjects, 14-16 yr old, performed a single, typical, 1.5-h water polo practice session. Blood was sampled before and after the session.

RESULTS

The exercise resulted in an increase in HR (from 82 +/- 2 to 161 +/- 5 beats.min(-1) at 30 min, P < 1.4.10(-6) ), as well as in circulating lactate levels (375 +/- 66%, P < 0.0005). Significant increases where noted in circulating IL-6 (396 +/- 162%, P < 0.005) and IL-1ra (71 +/- 20%, P < 0.015). A substantial increase in the level of IGFBP-1 (1344 +/- 344%, P < 0.001) was also observed. Interestingly, TNF-alpha levels decreased after the exercise (-10.4 +/- 3.8%, P < 0.04) as did insulin (55 +/- 12%, P < 0.005). The exercise led to significant increases in granulocytes, monocytes, and lymphocytes. The exercise significantly influenced adhesion molecules (such as CD62L and CD54), which has not been previously studied in adolescent girls.

CONCLUSIONS

These data demonstrate that an intense "real-life" exercise bout in adolescent females leads to profound increases in inflammatory cytokines and reductions in anabolic mediators with substantial alterations in white blood cell subpopulations and adhesion molecules. The role of these frequent, almost daily immune and cytokine changes on growth and development have yet to be determined.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Center for the Study of Health Effects of Exercise in Children, University of California, Irvine, CA 92868, USA.

    , ,

    Source

    MeSH

    Adolescent
    Antibody Formation
    Cell Adhesion Molecules
    Cytokines
    Exercise
    Female
    Granulocytes
    Human Growth Hormone
    Humans
    Immunity, Cellular
    Inflammation
    Lymphocytes
    Monocytes
    Sports

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    12569228

    Citation

    Nemet, Dan, et al. "Effect of Water Polo Practice On Cytokines, Growth Mediators, and Leukocytes in Girls." Medicine and Science in Sports and Exercise, vol. 35, no. 2, 2003, pp. 356-63.
    Nemet D, Rose-Gottron CM, Mills PJ, et al. Effect of water polo practice on cytokines, growth mediators, and leukocytes in girls. Med Sci Sports Exerc. 2003;35(2):356-63.
    Nemet, D., Rose-Gottron, C. M., Mills, P. J., & Cooper, D. M. (2003). Effect of water polo practice on cytokines, growth mediators, and leukocytes in girls. Medicine and Science in Sports and Exercise, 35(2), pp. 356-63.
    Nemet D, et al. Effect of Water Polo Practice On Cytokines, Growth Mediators, and Leukocytes in Girls. Med Sci Sports Exerc. 2003;35(2):356-63. PubMed PMID: 12569228.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of water polo practice on cytokines, growth mediators, and leukocytes in girls. AU - Nemet,Dan, AU - Rose-Gottron,Christie M, AU - Mills,Paul J, AU - Cooper,Dan M, PY - 2003/2/6/pubmed PY - 2003/5/7/medline PY - 2003/2/6/entrez SP - 356 EP - 63 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 35 IS - 2 N2 - PURPOSE: The effects of exercise on growth and development are mediated through a complex interaction between the endocrine, immune, and nervous systems. Very little is known about how these systems respond to exercise in children or adolescents. Moreover, there are few studies that have examined growth factors, inflammatory cytokines, and leukocyte responses to "real-life" or field exercise solely in girls. Thus, the goal of the present study was to determine the acute exercise-induced alterations in the growth hormone --> insulin-like growth factor-I axis, inflammatory cytokines, and certain aspects of immune function in a group of adolescent girls after a typical water polo practice. METHODS: Ten, healthy, high-school female subjects, 14-16 yr old, performed a single, typical, 1.5-h water polo practice session. Blood was sampled before and after the session. RESULTS: The exercise resulted in an increase in HR (from 82 +/- 2 to 161 +/- 5 beats.min(-1) at 30 min, P < 1.4.10(-6) ), as well as in circulating lactate levels (375 +/- 66%, P < 0.0005). Significant increases where noted in circulating IL-6 (396 +/- 162%, P < 0.005) and IL-1ra (71 +/- 20%, P < 0.015). A substantial increase in the level of IGFBP-1 (1344 +/- 344%, P < 0.001) was also observed. Interestingly, TNF-alpha levels decreased after the exercise (-10.4 +/- 3.8%, P < 0.04) as did insulin (55 +/- 12%, P < 0.005). The exercise led to significant increases in granulocytes, monocytes, and lymphocytes. The exercise significantly influenced adhesion molecules (such as CD62L and CD54), which has not been previously studied in adolescent girls. CONCLUSIONS: These data demonstrate that an intense "real-life" exercise bout in adolescent females leads to profound increases in inflammatory cytokines and reductions in anabolic mediators with substantial alterations in white blood cell subpopulations and adhesion molecules. The role of these frequent, almost daily immune and cytokine changes on growth and development have yet to be determined. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/12569228/Effect_of_water_polo_practice_on_cytokines_growth_mediators_and_leukocytes_in_girls_ L2 - http://Insights.ovid.com/pubmed?pmid=12569228 DB - PRIME DP - Unbound Medicine ER -