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Body composition and energy expenditure in Duchenne muscular dystrophy.
Eur J Clin Nutr 2003; 57(2):273-8EJ

Abstract

OBJECTIVE

To investigate the relationship between resting energy expenditure (REE) and body composition in Duchenne Muscular Dystrophy (DMD).

DESIGN

An observational study.

SETTING

University Research Centre.

SUBJECTS

Nine Duchenne children (age range 6-12 y), mean relative weight 128%, agreed to undergo the investigation and all of them completed the study;

INTERVENTIONS

Assessment of body composition (total body fat and skeletal muscle mass) by magnetic resonance imaging and resting energy expenditure by indirect calorimetry.

MAIN OUTCOME MEASURES

Fat mass (FM; kg and percentage weight), fat-free mass (FFM; kg and percentage weight), muscle mass (kg and percentage weight), resting energy expenditure (kJ/kg body weight and kJ/kg fat-free mass).

RESULTS

: In Duchenne children fat mass averages 32% and total skeletal muscle mass 20% of body weight. Resting energy expenditure per kg of body weight falls within the normal range for children of the same age range, while when expressed per kg of FFM is significantly higher than reference values. No relationship was found between REE and total skeletal muscle mass.

CONCLUSIONS

Our results do not demonstrate a low REE in DMD boys; on the contrary REE per kg of FFM is higher than normal, probably due to the altered FFM composition. We suggest that the development of obesity in DMD children is not primarily due to a low REE but to other causes such as a reduction in physical activity and or overfeeding.

Authors+Show Affiliations

Applied Health Sciences Department, University of Pavia, Pavia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12571659

Citation

Zanardi, M C., et al. "Body Composition and Energy Expenditure in Duchenne Muscular Dystrophy." European Journal of Clinical Nutrition, vol. 57, no. 2, 2003, pp. 273-8.
Zanardi MC, Tagliabue A, Orcesi S, et al. Body composition and energy expenditure in Duchenne muscular dystrophy. Eur J Clin Nutr. 2003;57(2):273-8.
Zanardi, M. C., Tagliabue, A., Orcesi, S., Berardinelli, A., Uggetti, C., & Pichiecchio, A. (2003). Body composition and energy expenditure in Duchenne muscular dystrophy. European Journal of Clinical Nutrition, 57(2), pp. 273-8.
Zanardi MC, et al. Body Composition and Energy Expenditure in Duchenne Muscular Dystrophy. Eur J Clin Nutr. 2003;57(2):273-8. PubMed PMID: 12571659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body composition and energy expenditure in Duchenne muscular dystrophy. AU - Zanardi,M C, AU - Tagliabue,A, AU - Orcesi,S, AU - Berardinelli,A, AU - Uggetti,C, AU - Pichiecchio,A, PY - 2001/09/12/received PY - 2002/04/29/revised PY - 2002/05/07/accepted PY - 2003/2/7/pubmed PY - 2003/7/17/medline PY - 2003/2/7/entrez SP - 273 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 2 N2 - OBJECTIVE: To investigate the relationship between resting energy expenditure (REE) and body composition in Duchenne Muscular Dystrophy (DMD). DESIGN: An observational study. SETTING: University Research Centre. SUBJECTS: Nine Duchenne children (age range 6-12 y), mean relative weight 128%, agreed to undergo the investigation and all of them completed the study; INTERVENTIONS: Assessment of body composition (total body fat and skeletal muscle mass) by magnetic resonance imaging and resting energy expenditure by indirect calorimetry. MAIN OUTCOME MEASURES: Fat mass (FM; kg and percentage weight), fat-free mass (FFM; kg and percentage weight), muscle mass (kg and percentage weight), resting energy expenditure (kJ/kg body weight and kJ/kg fat-free mass). RESULTS: : In Duchenne children fat mass averages 32% and total skeletal muscle mass 20% of body weight. Resting energy expenditure per kg of body weight falls within the normal range for children of the same age range, while when expressed per kg of FFM is significantly higher than reference values. No relationship was found between REE and total skeletal muscle mass. CONCLUSIONS: Our results do not demonstrate a low REE in DMD boys; on the contrary REE per kg of FFM is higher than normal, probably due to the altered FFM composition. We suggest that the development of obesity in DMD children is not primarily due to a low REE but to other causes such as a reduction in physical activity and or overfeeding. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12571659/Body_composition_and_energy_expenditure_in_Duchenne_muscular_dystrophy_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601524 DB - PRIME DP - Unbound Medicine ER -