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The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal.
Eur J Clin Nutr. 2003 Feb; 57(2):293-8.EJ

Abstract

OBJECTIVE

To assess whether the addition of viscous fiber at an amount recommended by the US FDA to allow a 'low saturated fat, cholesterol, soluble fiber and coronary heart disease', health claim label on a food package (1.7 g psyllium) and/or fat (30 g sunflower oil and 3 g sodium propionate) to a pasta meal would affect gastric emptying, postprandial glucose, insulin and GLP-1 concentrations.

DESIGN

Ten subjects participated in a two-by-two single blind randomized crossover study. Four meals containing 50 g of available carbohydrate were consumed: pasta with or without psyllium enrichment served with a tomato sauce with (520 kcal per meal) and without (240 kcal per meal) fat. Blood samples were taken for 240 min following the meal and all subjects consumed a buffet meal at the end of the study. Gastric emptying was measured using the paracetamol absorption test. Blood was analysed for glucose, insulin, GLP-1. Visual analog scales were used to record feelings of hunger, pleasantness and nausea.

RESULTS

The psyllium-enriched pasta had no significant effect on gastric emptying or the incremental area under the curve (IAUC) for GLP-1, insulin or glucose compared with the control pasta. The addition of polyunsaturated fat and sodium propionate significantly increased the IAUC for GLP-1 (P<0.001), delaying gastric emptying (P<0.002), and decreasing glucose (P<0.002).

CONCLUSIONS

A dose of 1.7 g psyllium did not evoke measurable effects on gastric emptying, postprandial GLP-1, insulin or glucose metabolism. However the addition of 30 g of oil and 3 g of sodium propionate to the pasta did reduce gastric emptying, increase GLP-1 and reduce glucose and insulin concentrations. While this short-term study may have implications in terms of reducing the risk of diabetes and improving coronary risk factor profiles the long term effects of these nutrients need to be studied.

Authors+Show Affiliations

Nutrition and Dietetic Research Group, Hammersmith Hospital, London, UK. gfrost@ic.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12571662

Citation

Frost, G S., et al. "The Effects of Fiber Enrichment of Pasta and Fat Content On Gastric Emptying, GLP-1, Glucose, and Insulin Responses to a Meal." European Journal of Clinical Nutrition, vol. 57, no. 2, 2003, pp. 293-8.
Frost GS, Brynes AE, Dhillo WS, et al. The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal. Eur J Clin Nutr. 2003;57(2):293-8.
Frost, G. S., Brynes, A. E., Dhillo, W. S., Bloom, S. R., & McBurney, M. I. (2003). The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal. European Journal of Clinical Nutrition, 57(2), 293-8.
Frost GS, et al. The Effects of Fiber Enrichment of Pasta and Fat Content On Gastric Emptying, GLP-1, Glucose, and Insulin Responses to a Meal. Eur J Clin Nutr. 2003;57(2):293-8. PubMed PMID: 12571662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal. AU - Frost,G S, AU - Brynes,A E, AU - Dhillo,W S, AU - Bloom,S R, AU - McBurney,M I, PY - 2002/03/01/received PY - 2002/04/09/revised PY - 2002/04/19/accepted PY - 2003/2/7/pubmed PY - 2003/7/17/medline PY - 2003/2/7/entrez SP - 293 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 2 N2 - OBJECTIVE: To assess whether the addition of viscous fiber at an amount recommended by the US FDA to allow a 'low saturated fat, cholesterol, soluble fiber and coronary heart disease', health claim label on a food package (1.7 g psyllium) and/or fat (30 g sunflower oil and 3 g sodium propionate) to a pasta meal would affect gastric emptying, postprandial glucose, insulin and GLP-1 concentrations. DESIGN: Ten subjects participated in a two-by-two single blind randomized crossover study. Four meals containing 50 g of available carbohydrate were consumed: pasta with or without psyllium enrichment served with a tomato sauce with (520 kcal per meal) and without (240 kcal per meal) fat. Blood samples were taken for 240 min following the meal and all subjects consumed a buffet meal at the end of the study. Gastric emptying was measured using the paracetamol absorption test. Blood was analysed for glucose, insulin, GLP-1. Visual analog scales were used to record feelings of hunger, pleasantness and nausea. RESULTS: The psyllium-enriched pasta had no significant effect on gastric emptying or the incremental area under the curve (IAUC) for GLP-1, insulin or glucose compared with the control pasta. The addition of polyunsaturated fat and sodium propionate significantly increased the IAUC for GLP-1 (P<0.001), delaying gastric emptying (P<0.002), and decreasing glucose (P<0.002). CONCLUSIONS: A dose of 1.7 g psyllium did not evoke measurable effects on gastric emptying, postprandial GLP-1, insulin or glucose metabolism. However the addition of 30 g of oil and 3 g of sodium propionate to the pasta did reduce gastric emptying, increase GLP-1 and reduce glucose and insulin concentrations. While this short-term study may have implications in terms of reducing the risk of diabetes and improving coronary risk factor profiles the long term effects of these nutrients need to be studied. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12571662/The_effects_of_fiber_enrichment_of_pasta_and_fat_content_on_gastric_emptying_GLP_1_glucose_and_insulin_responses_to_a_meal_ L2 - https://doi.org/10.1038/sj.ejcn.1601520 DB - PRIME DP - Unbound Medicine ER -