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[Chemopreventive effect of tea and curcumin on DMBA-induced oral carcinogenesis in hamsters].
Wei Sheng Yan Jiu. 2002 Oct; 31(5):354-7.WS

Abstract

0.5% DMBA solution (in mineral oil) was applied topically to the left cheek pouch of male Syrian golden hamsters 3 times per week for 6 weeks. After the last treatment of DMBA, the animals received 0.6% green tea powder as drinking fluid, or 10 mumol curcumin applied topically 3 times per week, or the combination of green tea and curcumin treatment, or no treatment for 18 weeks. The combination of tea and curcumin significantly decreased the oral visible tumor incidence and the squamous cell carcinoma (SCC) incidence. The combination of tea and curcumin also decreased the number of visible tumors and the tumor volume as well as the numbers of SCC, dysplasic lesions, and papillomas respectively. Green tea or curcumin treatment decreased the number of visible tumor, the tumor volume and the number of SCC respectively. Green tea also decreased the number of dysplasic lesions. Curcumin also significantly decreased the SCC incidence. Tea and curcumin, singly or in combination decreased bromodeoxyuridine (BrdU)-labeling index in hyperplasia, dysplasia, and papillomas. Tea alone and in combination with curcumin significantly increased the apoptotic index in dysplasia and SCC. Curcumin alone and in combination with tea inhibited the angiogenesis in papilloma and SCC. The results suggested that green tea and curcumin had inhibitory effects against oral carcinogenesis at the post-initiation stage and such inhibition may be related to the suppression of cell proliferation, induction of apoptosis, and inhibition of angiogenesis.

Authors+Show Affiliations

Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

chi

PubMed ID

12572355

Citation

Li, Ning, et al. "[Chemopreventive Effect of Tea and Curcumin On DMBA-induced Oral Carcinogenesis in Hamsters]." Wei Sheng Yan Jiu = Journal of Hygiene Research, vol. 31, no. 5, 2002, pp. 354-7.
Li N, Chen X, Han C, et al. [Chemopreventive effect of tea and curcumin on DMBA-induced oral carcinogenesis in hamsters]. Wei Sheng Yan Jiu. 2002;31(5):354-7.
Li, N., Chen, X., Han, C., & Chen, J. (2002). [Chemopreventive effect of tea and curcumin on DMBA-induced oral carcinogenesis in hamsters]. Wei Sheng Yan Jiu = Journal of Hygiene Research, 31(5), 354-7.
Li N, et al. [Chemopreventive Effect of Tea and Curcumin On DMBA-induced Oral Carcinogenesis in Hamsters]. Wei Sheng Yan Jiu. 2002;31(5):354-7. PubMed PMID: 12572355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Chemopreventive effect of tea and curcumin on DMBA-induced oral carcinogenesis in hamsters]. AU - Li,Ning, AU - Chen,Xiaoxin, AU - Han,Chi, AU - Chen,Junshi, PY - 2003/2/8/pubmed PY - 2003/8/20/medline PY - 2003/2/8/entrez SP - 354 EP - 7 JF - Wei sheng yan jiu = Journal of hygiene research JO - Wei Sheng Yan Jiu VL - 31 IS - 5 N2 - 0.5% DMBA solution (in mineral oil) was applied topically to the left cheek pouch of male Syrian golden hamsters 3 times per week for 6 weeks. After the last treatment of DMBA, the animals received 0.6% green tea powder as drinking fluid, or 10 mumol curcumin applied topically 3 times per week, or the combination of green tea and curcumin treatment, or no treatment for 18 weeks. The combination of tea and curcumin significantly decreased the oral visible tumor incidence and the squamous cell carcinoma (SCC) incidence. The combination of tea and curcumin also decreased the number of visible tumors and the tumor volume as well as the numbers of SCC, dysplasic lesions, and papillomas respectively. Green tea or curcumin treatment decreased the number of visible tumor, the tumor volume and the number of SCC respectively. Green tea also decreased the number of dysplasic lesions. Curcumin also significantly decreased the SCC incidence. Tea and curcumin, singly or in combination decreased bromodeoxyuridine (BrdU)-labeling index in hyperplasia, dysplasia, and papillomas. Tea alone and in combination with curcumin significantly increased the apoptotic index in dysplasia and SCC. Curcumin alone and in combination with tea inhibited the angiogenesis in papilloma and SCC. The results suggested that green tea and curcumin had inhibitory effects against oral carcinogenesis at the post-initiation stage and such inhibition may be related to the suppression of cell proliferation, induction of apoptosis, and inhibition of angiogenesis. SN - 1000-8020 UR - https://www.unboundmedicine.com/medline/citation/12572355/[Chemopreventive_effect_of_tea_and_curcumin_on_DMBA_induced_oral_carcinogenesis_in_hamsters]_ L2 - https://medlineplus.gov/oralcancer.html DB - PRIME DP - Unbound Medicine ER -