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[Clinical observation on treatment of rheumatoid arthritis by combined therapy with methotrexate, sulfasalazine and Chinese herbal medicine].

Abstract

OBJECTIVE

To observe the effect of Fengshi No. 1 (FS1) in treating patients with active stage of rheumatoid arthritis (RA).

METHODS

Patients with RA were randomly divided into two groups, the 40 patients in the treated group were treated with combined therapy of methotrexate (MTX), sulfasalazine (SSZ) and FS1, and the 20 in the control groups were treated with MTX and SSZ alone.

RESULTS

In the treated group, the total effective rate was 97.5%, the clinical controlled and markedly effective rate 95.0% and the occurrence rate of side-toxic reaction 10.0%, as compared with those in the control group, 60.0%, 20.0% and 45.0% respectively, the difference was significant (chi 2 = 11.91, 32.23 and 7.67 respectively, all P < 0.01). The effect in the treated group was superior to that in the control group in abating joint swelling and pain, improving function of joint, reducing immune indices and ameliorating iconographic features (P < 0.01 or P < 0.05).

CONCLUSION

FS1 not only has the effects of anti-inflammation, analgesis, regulating immune reaction, but also could retard the occurring of bone destruction, reduce the toxic-side effects of MTX and SSZ.

Authors+Show Affiliations

,

Victory Hospital of Victory Petroleum Administration, Shandong 257055.

,

Source

MeSH

Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal
Arthritis, Rheumatoid
Drug Therapy, Combination
Drugs, Chinese Herbal
Female
Humans
Male
Methotrexate
Middle Aged
Phytotherapy
Sulfasalazine

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12572373

Citation

Lu, Si-jian, et al. "[Clinical Observation On Treatment of Rheumatoid Arthritis By Combined Therapy With Methotrexate, Sulfasalazine and Chinese Herbal Medicine]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 22, no. 8, 2002, pp. 571-3.
Lu SJ, Shao J, Li XR. [Clinical observation on treatment of rheumatoid arthritis by combined therapy with methotrexate, sulfasalazine and Chinese herbal medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002;22(8):571-3.
Lu, S. J., Shao, J., & Li, X. R. (2002). [Clinical observation on treatment of rheumatoid arthritis by combined therapy with methotrexate, sulfasalazine and Chinese herbal medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 22(8), pp. 571-3.
Lu SJ, Shao J, Li XR. [Clinical Observation On Treatment of Rheumatoid Arthritis By Combined Therapy With Methotrexate, Sulfasalazine and Chinese Herbal Medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002;22(8):571-3. PubMed PMID: 12572373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical observation on treatment of rheumatoid arthritis by combined therapy with methotrexate, sulfasalazine and Chinese herbal medicine]. AU - Lu,Si-jian, AU - Shao,Jing, AU - Li,Xiang-ru, PY - 2003/2/8/pubmed PY - 2003/4/16/medline PY - 2003/2/8/entrez SP - 571 EP - 3 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 22 IS - 8 N2 - OBJECTIVE: To observe the effect of Fengshi No. 1 (FS1) in treating patients with active stage of rheumatoid arthritis (RA). METHODS: Patients with RA were randomly divided into two groups, the 40 patients in the treated group were treated with combined therapy of methotrexate (MTX), sulfasalazine (SSZ) and FS1, and the 20 in the control groups were treated with MTX and SSZ alone. RESULTS: In the treated group, the total effective rate was 97.5%, the clinical controlled and markedly effective rate 95.0% and the occurrence rate of side-toxic reaction 10.0%, as compared with those in the control group, 60.0%, 20.0% and 45.0% respectively, the difference was significant (chi 2 = 11.91, 32.23 and 7.67 respectively, all P < 0.01). The effect in the treated group was superior to that in the control group in abating joint swelling and pain, improving function of joint, reducing immune indices and ameliorating iconographic features (P < 0.01 or P < 0.05). CONCLUSION: FS1 not only has the effects of anti-inflammation, analgesis, regulating immune reaction, but also could retard the occurring of bone destruction, reduce the toxic-side effects of MTX and SSZ. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/12572373/[Clinical_observation_on_treatment_of_rheumatoid_arthritis_by_combined_therapy_with_methotrexate_sulfasalazine_and_Chinese_herbal_medicine]_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -