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Acute fatty liver in pregnancy.
Neth J Med. 2002 Oct; 60(9):370-3.NJ

Abstract

When confronted with liver abnormalities during the third trimester of pregnancy, one should consider acute fatty liver of pregnancy. The differential diagnosis with (pre-)eclampsia and HELLP syndrome is sometimes difficult. In these cases a liver biopsy is helpful though rarely performed during pregnancy. After delivery of the child the liver test abnormalities will ultimately disappear. Recent publications reveal that a dysfunction in the beta-oxidation of mitochondrial fatty acids may contribute to the aetiology of this rare disorder. We describe a case of acute fatty liver in pregnancy, with liver dysfunction (decreased albumin, prolonged prothrombin time) slowly returning to normal after delivery. Testing for disorders in beta-oxidation of mitochondrial fatty acids did not reveal abnormalities in mother or child.

Authors+Show Affiliations

Tan AC
Department of Gastroenterology, University Medical Centre St Radboud, Nijmegen, The Netherlands. a.tan@hccnet.nl
van Krieken JH
No affiliation info available
Peters WH
No affiliation info available
Steegers EA
No affiliation info available

MeSH

Acute DiseaseAdultDiagnosis, DifferentialFatty LiverFemaleHELLP SyndromeHumansPre-EclampsiaPregnancyPregnancy Complications

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12572711

Citation

Tan, A C I T L., et al. "Acute Fatty Liver in Pregnancy." The Netherlands Journal of Medicine, vol. 60, no. 9, 2002, pp. 370-3.
Tan AC, van Krieken JH, Peters WH, et al. Acute fatty liver in pregnancy. Neth J Med. 2002;60(9):370-3.
Tan, A. C., van Krieken, J. H., Peters, W. H., & Steegers, E. A. (2002). Acute fatty liver in pregnancy. The Netherlands Journal of Medicine, 60(9), 370-3.
Tan AC, et al. Acute Fatty Liver in Pregnancy. Neth J Med. 2002;60(9):370-3. PubMed PMID: 12572711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute fatty liver in pregnancy. AU - Tan,A C I T L, AU - van Krieken,J H J M, AU - Peters,W H M, AU - Steegers,E A P, PY - 2003/2/8/pubmed PY - 2003/4/2/medline PY - 2003/2/8/entrez SP - 370 EP - 3 JF - The Netherlands journal of medicine JO - Neth J Med VL - 60 IS - 9 N2 - When confronted with liver abnormalities during the third trimester of pregnancy, one should consider acute fatty liver of pregnancy. The differential diagnosis with (pre-)eclampsia and HELLP syndrome is sometimes difficult. In these cases a liver biopsy is helpful though rarely performed during pregnancy. After delivery of the child the liver test abnormalities will ultimately disappear. Recent publications reveal that a dysfunction in the beta-oxidation of mitochondrial fatty acids may contribute to the aetiology of this rare disorder. We describe a case of acute fatty liver in pregnancy, with liver dysfunction (decreased albumin, prolonged prothrombin time) slowly returning to normal after delivery. Testing for disorders in beta-oxidation of mitochondrial fatty acids did not reveal abnormalities in mother or child. SN - 0300-2977 UR - https://www.unboundmedicine.com/medline/citation/12572711/Acute_fatty_liver_in_pregnancy_ DB - PRIME DP - Unbound Medicine ER -