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Effects of exercise training on bone remodeling, insulin-like growth factors, and bone mineral density in postmenopausal women with and without hormone replacement therapy.
Calcif Tissue Int. 2003 Apr; 72(4):478-84.CT

Abstract

The purpose of this study was to determine the effects of 12 months of weight bearing and resistance exercise on bone mineral density (BMD) and bone remodeling (bone formation and bone resorption) in 2 groups of postmenopausal women either with or without hormone replacement therapy (HRT). Secondary aims were to characterize the changes in insulin-like growth factors-1 and -2 (IGF-1 and -2) and IGF binding protein 3 (IGFBP3) in response to exercise training. Women who were 3-10 years postmenopausal (aged 40-65 years) were included in the study. Women in the HRT and no HRT groups were randomized into the exercise intervention, resulting in four groups: (1) women not taking HRT, not exercising; (2) those taking HRT, not exercising; (3) those exercising, not taking HRT; and (4) women exercising, taking HRT. The number of subjects per group after 1 year was 27, 21, 25, and 17, respectively. HRT increased BMD at most sites whereas the combination of exercise and HRT produced increases in BMD greater than either treatment alone. Exercise training alone resulted in modest site-specific increases in BMD. Bone remodeling was suppressed in the groups taking HRT regardless of exercise status. The bone remodeling response to exercise training in women not taking HRT was not significantly different from those not exercising. However, the direction of change suggests an elevation in bone remodeling in response to exercise training, a phenomenon usually associated with bone loss. No training-induced differences in IGF-1, IGF-2, IGF-l:IGF-2 (IGF-1 : IGF-2), and IGFBP3 were detected.

Authors+Show Affiliations

Department of Exercise Science and Physical Education, University of Massachusetts Boston, 100 Morrissey Blvd., 02125, USA. laurie.milliken@umb.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12574871

Citation

Milliken, L A., et al. "Effects of Exercise Training On Bone Remodeling, Insulin-like Growth Factors, and Bone Mineral Density in Postmenopausal Women With and Without Hormone Replacement Therapy." Calcified Tissue International, vol. 72, no. 4, 2003, pp. 478-84.
Milliken LA, Going SB, Houtkooper LB, et al. Effects of exercise training on bone remodeling, insulin-like growth factors, and bone mineral density in postmenopausal women with and without hormone replacement therapy. Calcif Tissue Int. 2003;72(4):478-84.
Milliken, L. A., Going, S. B., Houtkooper, L. B., Flint-Wagner, H. G., Figueroa, A., Metcalfe, L. L., Blew, R. M., Sharp, S. C., & Lohman, T. G. (2003). Effects of exercise training on bone remodeling, insulin-like growth factors, and bone mineral density in postmenopausal women with and without hormone replacement therapy. Calcified Tissue International, 72(4), 478-84.
Milliken LA, et al. Effects of Exercise Training On Bone Remodeling, Insulin-like Growth Factors, and Bone Mineral Density in Postmenopausal Women With and Without Hormone Replacement Therapy. Calcif Tissue Int. 2003;72(4):478-84. PubMed PMID: 12574871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of exercise training on bone remodeling, insulin-like growth factors, and bone mineral density in postmenopausal women with and without hormone replacement therapy. AU - Milliken,L A, AU - Going,S B, AU - Houtkooper,L B, AU - Flint-Wagner,H G, AU - Figueroa,A, AU - Metcalfe,L L, AU - Blew,R M, AU - Sharp,S C, AU - Lohman,T G, Y1 - 2003/02/10/ PY - 2001/10/30/received PY - 2002/09/11/accepted PY - 2003/2/8/pubmed PY - 2004/1/22/medline PY - 2003/2/8/entrez SP - 478 EP - 84 JF - Calcified tissue international JO - Calcif. Tissue Int. VL - 72 IS - 4 N2 - The purpose of this study was to determine the effects of 12 months of weight bearing and resistance exercise on bone mineral density (BMD) and bone remodeling (bone formation and bone resorption) in 2 groups of postmenopausal women either with or without hormone replacement therapy (HRT). Secondary aims were to characterize the changes in insulin-like growth factors-1 and -2 (IGF-1 and -2) and IGF binding protein 3 (IGFBP3) in response to exercise training. Women who were 3-10 years postmenopausal (aged 40-65 years) were included in the study. Women in the HRT and no HRT groups were randomized into the exercise intervention, resulting in four groups: (1) women not taking HRT, not exercising; (2) those taking HRT, not exercising; (3) those exercising, not taking HRT; and (4) women exercising, taking HRT. The number of subjects per group after 1 year was 27, 21, 25, and 17, respectively. HRT increased BMD at most sites whereas the combination of exercise and HRT produced increases in BMD greater than either treatment alone. Exercise training alone resulted in modest site-specific increases in BMD. Bone remodeling was suppressed in the groups taking HRT regardless of exercise status. The bone remodeling response to exercise training in women not taking HRT was not significantly different from those not exercising. However, the direction of change suggests an elevation in bone remodeling in response to exercise training, a phenomenon usually associated with bone loss. No training-induced differences in IGF-1, IGF-2, IGF-l:IGF-2 (IGF-1 : IGF-2), and IGFBP3 were detected. SN - 0171-967X UR - https://www.unboundmedicine.com/medline/citation/12574871/Effects_of_exercise_training_on_bone_remodeling_insulin_like_growth_factors_and_bone_mineral_density_in_postmenopausal_women_with_and_without_hormone_replacement_therapy_ L2 - https://dx.doi.org/10.1007/s00223-001-1128-5 DB - PRIME DP - Unbound Medicine ER -