Tags

Type your tag names separated by a space and hit enter

Subacute cutaneous lupus erythematosus induced by nifedipine.
J Cutan Med Surg. 2003 May-Jun; 7(3):243-6.JC

Abstract

BACKGROUND

Subacute cutaneous lupus erythematosus (SCLE) has been reported to be associated with the use of several drugs, including thiazides, terbinafine, and, rarely, calcium channel blockers.

OBJECTIVE

A case of SCLE induced by nifedipine is presented.

METHODS AND RESULTS

A 48-year-old white woman developed a papulosquamous and annular eruption in sun-exposed areas during the summer. The patient was taking nifedipine for essential hypertension for four years. Serology showed the presence of antinuclear and anti-Ro/SSA as well as antihistone antibodies. Histopathologic and immunopathologic (granular IgM deposits at the dermoepidermal junction) findings confirmed the diagnosis of SCLE. Nifedipine discontinuation led to rapid improvement with almost complete resolution of skin lesions in one month in the absence of active treatment. Reduction of antinuclear, anti-Ro/SSA, and antihistone antibody levels was documented after six months.

CONCLUSION

Nifedipine can cause SCLE after a long period of administration. Antihistone antibodies may be associated with drug-induced SCLE.

Authors+Show Affiliations

Gubinelli E
Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy.
Cocuroccia B
No affiliation info available
Girolomoni G
No affiliation info available

MeSH

Calcium Channel BlockersFemaleHumansLupus Erythematosus, CutaneousMiddle AgedNifedipine

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12574905

Citation

Gubinelli, Emanuela, et al. "Subacute Cutaneous Lupus Erythematosus Induced By Nifedipine." Journal of Cutaneous Medicine and Surgery, vol. 7, no. 3, 2003, pp. 243-6.
Gubinelli E, Cocuroccia B, Girolomoni G. Subacute cutaneous lupus erythematosus induced by nifedipine. J Cutan Med Surg. 2003;7(3):243-6.
Gubinelli, E., Cocuroccia, B., & Girolomoni, G. (2003). Subacute cutaneous lupus erythematosus induced by nifedipine. Journal of Cutaneous Medicine and Surgery, 7(3), 243-6.
Gubinelli E, Cocuroccia B, Girolomoni G. Subacute Cutaneous Lupus Erythematosus Induced By Nifedipine. J Cutan Med Surg. 2003 May-Jun;7(3):243-6. PubMed PMID: 12574905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subacute cutaneous lupus erythematosus induced by nifedipine. AU - Gubinelli,Emanuela, AU - Cocuroccia,Barbara, AU - Girolomoni,Giampiero, PY - 2003/2/8/pubmed PY - 2005/7/1/medline PY - 2003/2/8/entrez SP - 243 EP - 6 JF - Journal of cutaneous medicine and surgery JO - J Cutan Med Surg VL - 7 IS - 3 N2 - BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE) has been reported to be associated with the use of several drugs, including thiazides, terbinafine, and, rarely, calcium channel blockers. OBJECTIVE: A case of SCLE induced by nifedipine is presented. METHODS AND RESULTS: A 48-year-old white woman developed a papulosquamous and annular eruption in sun-exposed areas during the summer. The patient was taking nifedipine for essential hypertension for four years. Serology showed the presence of antinuclear and anti-Ro/SSA as well as antihistone antibodies. Histopathologic and immunopathologic (granular IgM deposits at the dermoepidermal junction) findings confirmed the diagnosis of SCLE. Nifedipine discontinuation led to rapid improvement with almost complete resolution of skin lesions in one month in the absence of active treatment. Reduction of antinuclear, anti-Ro/SSA, and antihistone antibody levels was documented after six months. CONCLUSION: Nifedipine can cause SCLE after a long period of administration. Antihistone antibodies may be associated with drug-induced SCLE. SN - 1203-4754 UR - https://www.unboundmedicine.com/medline/citation/12574905/Subacute_cutaneous_lupus_erythematosus_induced_by_nifedipine_ DB - PRIME DP - Unbound Medicine ER -