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[Study of effect of zhichuan capsule on airway remodeling in experimental animal model of asthma].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 Aug; 21(8):599-601.ZZ

Abstract

OBJECTIVE

To elucidate the effect and possible mechanism of Zhichuan Capsule (ZCC), a Chinese herbal preparation for reinforcing Kidney and invigorating Spleen, on airway remodeling when it was used in treating asthma.

METHODS

Fifty SD rats were randomly divided into five groups: the normal control group, the model group, the high-dosage ZCC group, the low-dosage ZCC group and the Becotide (Beclomethasone Dipropionate) group, 10 rats in each group. The chronic asthma model was established by repeated inhalation of ovalbumin. The changes of collagen and fibronectin (Fn) content in airway wall, inner and outer diameter as well as area of respiratory tract cavity in lung slices were measured by computerized image analysis system.

RESULTS

The wall contents of collagen and Fn in airway were higher (P < 0.05 and P < 0.01), while the ratio of inner diameter/outer diameter (ID/OD) and ratio of area of airway cavity/total area of airway (CA/TA) were significantly lower (P < 0.01) in the model animals than those in the normal controls. As compared with the model group, collagen and Fn contents were lower, ID/OD and CA/TA ratio were significantly higher in high-dosage ZCC group, close to normal range. In the low-dosage ZCC group, although collagen content, ID/OD and CA/TA were not different to those in the model group, but the content of Fn was significantly lower (P < 0.01).

CONCLUSION

ZCC could inhibit the remodeling of airway in chronic asthma by way of reducing the precipitation of collagen and Fn, thus help the prevention and treatment of chronic bronchial asthma.

Authors+Show Affiliations

Longhua Hospital of Shanghai University of TCM, Shanghai 200032.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12575575

Citation

Lin, L, et al. "[Study of Effect of Zhichuan Capsule On Airway Remodeling in Experimental Animal Model of Asthma]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 21, no. 8, 2001, pp. 599-601.
Lin L, Yao QB, Yu SX. [Study of effect of zhichuan capsule on airway remodeling in experimental animal model of asthma]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(8):599-601.
Lin, L., Yao, Q. B., & Yu, S. X. (2001). [Study of effect of zhichuan capsule on airway remodeling in experimental animal model of asthma]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 21(8), 599-601.
Lin L, Yao QB, Yu SX. [Study of Effect of Zhichuan Capsule On Airway Remodeling in Experimental Animal Model of Asthma]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001;21(8):599-601. PubMed PMID: 12575575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study of effect of zhichuan capsule on airway remodeling in experimental animal model of asthma]. AU - Lin,L, AU - Yao,Q B, AU - Yu,S X, PY - 2003/2/11/pubmed PY - 2003/4/30/medline PY - 2003/2/11/entrez SP - 599 EP - 601 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 21 IS - 8 N2 - OBJECTIVE: To elucidate the effect and possible mechanism of Zhichuan Capsule (ZCC), a Chinese herbal preparation for reinforcing Kidney and invigorating Spleen, on airway remodeling when it was used in treating asthma. METHODS: Fifty SD rats were randomly divided into five groups: the normal control group, the model group, the high-dosage ZCC group, the low-dosage ZCC group and the Becotide (Beclomethasone Dipropionate) group, 10 rats in each group. The chronic asthma model was established by repeated inhalation of ovalbumin. The changes of collagen and fibronectin (Fn) content in airway wall, inner and outer diameter as well as area of respiratory tract cavity in lung slices were measured by computerized image analysis system. RESULTS: The wall contents of collagen and Fn in airway were higher (P < 0.05 and P < 0.01), while the ratio of inner diameter/outer diameter (ID/OD) and ratio of area of airway cavity/total area of airway (CA/TA) were significantly lower (P < 0.01) in the model animals than those in the normal controls. As compared with the model group, collagen and Fn contents were lower, ID/OD and CA/TA ratio were significantly higher in high-dosage ZCC group, close to normal range. In the low-dosage ZCC group, although collagen content, ID/OD and CA/TA were not different to those in the model group, but the content of Fn was significantly lower (P < 0.01). CONCLUSION: ZCC could inhibit the remodeling of airway in chronic asthma by way of reducing the precipitation of collagen and Fn, thus help the prevention and treatment of chronic bronchial asthma. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/12575575/[Study_of_effect_of_zhichuan_capsule_on_airway_remodeling_in_experimental_animal_model_of_asthma]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -