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Spur cell anemia in alcoholic cirrhosis: cure by orthotopic liver transplantation and recurrence after liver graft failure.
Int Surg. 2002 Oct-Dec; 87(4):201-4.IS

Abstract

Spur cell anemia is an acquired form of hemolytic anemia caused by a structural abnormality of red cell membranes that results in spiculated erythrocytes. These peculiarly shaped red blood cells, called acanthocytes, have a shortened survival and undergo splenic sequestration and destruction. Spur cell anemia has been known to occur in several conditions, including chronic liver disease, and more specifically in alcoholic cirrhosis. Treatment of this disorder has been disappointing and usually indicates end-stage liver disease. Liver transplantation has been reported as the most effective treatment. We herein present a case of severe spur cell hemolytic anemia that successfully reverted after orthotopic liver transplantation and recurred secondary to resumption of alcohol intake and consequent liver graft failure. This case conclusively demonstrates the association among alcoholic cirrhosis, end-stage liver disease, and spur cell hemolytic anemia.

Authors+Show Affiliations

Department of Medicine, Sturgis Hospital, Sturgis, Michigan, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12575799

Citation

Malik, Pramod, et al. "Spur Cell Anemia in Alcoholic Cirrhosis: Cure By Orthotopic Liver Transplantation and Recurrence After Liver Graft Failure." International Surgery, vol. 87, no. 4, 2002, pp. 201-4.
Malik P, Bogetti D, Sileri P, et al. Spur cell anemia in alcoholic cirrhosis: cure by orthotopic liver transplantation and recurrence after liver graft failure. Int Surg. 2002;87(4):201-4.
Malik, P., Bogetti, D., Sileri, P., Testa, G., Blumenthal, S. A., Wiley, T. E., Layden, T. J., & Benedetti, E. (2002). Spur cell anemia in alcoholic cirrhosis: cure by orthotopic liver transplantation and recurrence after liver graft failure. International Surgery, 87(4), 201-4.
Malik P, et al. Spur Cell Anemia in Alcoholic Cirrhosis: Cure By Orthotopic Liver Transplantation and Recurrence After Liver Graft Failure. Int Surg. 2002 Oct-Dec;87(4):201-4. PubMed PMID: 12575799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spur cell anemia in alcoholic cirrhosis: cure by orthotopic liver transplantation and recurrence after liver graft failure. AU - Malik,Pramod, AU - Bogetti,Diego, AU - Sileri,Pierpaolo, AU - Testa,Giuliano, AU - Blumenthal,Stanley A, AU - Wiley,Thelma E, AU - Layden,Thomas J, AU - Benedetti,Enrico, PY - 2003/2/11/pubmed PY - 2003/8/2/medline PY - 2003/2/11/entrez SP - 201 EP - 4 JF - International surgery JO - Int Surg VL - 87 IS - 4 N2 - Spur cell anemia is an acquired form of hemolytic anemia caused by a structural abnormality of red cell membranes that results in spiculated erythrocytes. These peculiarly shaped red blood cells, called acanthocytes, have a shortened survival and undergo splenic sequestration and destruction. Spur cell anemia has been known to occur in several conditions, including chronic liver disease, and more specifically in alcoholic cirrhosis. Treatment of this disorder has been disappointing and usually indicates end-stage liver disease. Liver transplantation has been reported as the most effective treatment. We herein present a case of severe spur cell hemolytic anemia that successfully reverted after orthotopic liver transplantation and recurred secondary to resumption of alcohol intake and consequent liver graft failure. This case conclusively demonstrates the association among alcoholic cirrhosis, end-stage liver disease, and spur cell hemolytic anemia. SN - 0020-8868 UR - https://www.unboundmedicine.com/medline/citation/12575799/Spur_cell_anemia_in_alcoholic_cirrhosis:_cure_by_orthotopic_liver_transplantation_and_recurrence_after_liver_graft_failure_ L2 - http://www.diseaseinfosearch.org/result/441 DB - PRIME DP - Unbound Medicine ER -