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Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis.
J Neuroimmunol 2003; 135(1-2):117-25JN

Abstract

Humoral auto-immunity to the myelin oligodendrocyte glycoprotein (MOG) is likely involved in the pathogenesis of multiple sclerosis (MS). In 44 MS patients and 30 controls, Ig-producing B cells were identified by their isotype and as MOG-specific spot-forming cells (SFC). Peripheral anti-MOG antibodies were assayed in ELISA as well as anti-butyrophilin antibodies to investigate for molecular mimicry. MS patients had significantly higher levels of IgA- and MOG-SFC than controls, as well as significantly higher antibody responses to MOG and butyrophilin. These data provide added support for the implication of anti-MOG humoral immunity in the pathophysiology of MS, and suggest a balance of systemic (anti-self) and mucosal (environment-modulated) immune reactions in an attempt at regulating the pathogenic specific immune response.

Authors+Show Affiliations

Laboratoire d'Immunologie du CHU, Faculté de Médecine, BP 184, 54500 Vandoeuvre les, 54000, Nancy, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12576231

Citation

Kennel De March, A, et al. "Anti-myelin Oligodendrocyte Glycoprotein B-cell Responses in Multiple Sclerosis." Journal of Neuroimmunology, vol. 135, no. 1-2, 2003, pp. 117-25.
Kennel De March A, De Bouwerie M, Kolopp-Sarda MN, et al. Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis. J Neuroimmunol. 2003;135(1-2):117-25.
Kennel De March, A., De Bouwerie, M., Kolopp-Sarda, M. N., Faure, G. C., Béné, M. C., & Bernard, C. C. (2003). Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis. Journal of Neuroimmunology, 135(1-2), pp. 117-25.
Kennel De March A, et al. Anti-myelin Oligodendrocyte Glycoprotein B-cell Responses in Multiple Sclerosis. J Neuroimmunol. 2003;135(1-2):117-25. PubMed PMID: 12576231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis. AU - Kennel De March,A, AU - De Bouwerie,M, AU - Kolopp-Sarda,M N, AU - Faure,G C, AU - Béné,M C, AU - Bernard,C C A, PY - 2003/2/11/pubmed PY - 2003/3/21/medline PY - 2003/2/11/entrez SP - 117 EP - 25 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 135 IS - 1-2 N2 - Humoral auto-immunity to the myelin oligodendrocyte glycoprotein (MOG) is likely involved in the pathogenesis of multiple sclerosis (MS). In 44 MS patients and 30 controls, Ig-producing B cells were identified by their isotype and as MOG-specific spot-forming cells (SFC). Peripheral anti-MOG antibodies were assayed in ELISA as well as anti-butyrophilin antibodies to investigate for molecular mimicry. MS patients had significantly higher levels of IgA- and MOG-SFC than controls, as well as significantly higher antibody responses to MOG and butyrophilin. These data provide added support for the implication of anti-MOG humoral immunity in the pathophysiology of MS, and suggest a balance of systemic (anti-self) and mucosal (environment-modulated) immune reactions in an attempt at regulating the pathogenic specific immune response. SN - 0165-5728 UR - https://www.unboundmedicine.com/medline/citation/12576231/Anti_myelin_oligodendrocyte_glycoprotein_B_cell_responses_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165572802004344 DB - PRIME DP - Unbound Medicine ER -