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Na+-K+-activated adenosine triphosphatase and intestinal electrolyte transport. Effect of adrenal steroids.
J Clin Invest. 1975 Sep; 56(3):653-60.JCI

Abstract

Sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) is associated with electrolyte transport in many tissues. To help delineate its role in intestinal transport, changes in rat intestinal electrolyte and water transport induced by injecting methylprednisolone acetate 3 mg/100 g or deoxycorticosterone acetate (DOCA) 0.5 mg/100 g per day for 3 days were correlated with changes in Na-K-ATPase activity. Methylprednisolone increased sodium and water absorption, potassium secretion, transmural potential difference, and Na-K-ATPase activity in the jejunum, ileum, and colon. Examination of isolated epithelial cells demonstrated that the jejunal and ileal increase in Na-K-ATPase occurred in both the villus tip and crypermeability, Mg-ATPase, and adenylate cyclase activities were unchanged by methylprednisolone. DOCA increased sodium and water absorption, potassium secretion, transmural potential difference, and Na-K-ATPase activity in the colon alone. Colonic Mg-ATPase and adenylate cyclase activities were unaffected. Jejunal and ileal enzyme activity, electrolyte transport, and permeability were unchanged by DOCA. Methylprednisolone and DOCA were not additive in their effect on colonic Na-K-ATPase activity. Methylprednisolone and DOCA increased electrolyte and water transport and Na-K-ATPase activity concomitantly in specific segments of small intestine and colon. These data are consistent with an important role for Na-K-ATPase in intestinal electrolyte and water transport.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

125764

Citation

Charney, A N., et al. "Na+-K+-activated Adenosine Triphosphatase and Intestinal Electrolyte Transport. Effect of Adrenal Steroids." The Journal of Clinical Investigation, vol. 56, no. 3, 1975, pp. 653-60.
Charney AN, Kinsey MD, Myers L, et al. Na+-K+-activated adenosine triphosphatase and intestinal electrolyte transport. Effect of adrenal steroids. J Clin Invest. 1975;56(3):653-60.
Charney, A. N., Kinsey, M. D., Myers, L., Gainnella, R. A., & Gots, R. E. (1975). Na+-K+-activated adenosine triphosphatase and intestinal electrolyte transport. Effect of adrenal steroids. The Journal of Clinical Investigation, 56(3), 653-60.
Charney AN, et al. Na+-K+-activated Adenosine Triphosphatase and Intestinal Electrolyte Transport. Effect of Adrenal Steroids. J Clin Invest. 1975;56(3):653-60. PubMed PMID: 125764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Na+-K+-activated adenosine triphosphatase and intestinal electrolyte transport. Effect of adrenal steroids. AU - Charney,A N, AU - Kinsey,M D, AU - Myers,L, AU - Gainnella,R A, AU - Gots,R E, PY - 1975/9/1/pubmed PY - 1975/9/1/medline PY - 1975/9/1/entrez SP - 653 EP - 60 JF - The Journal of clinical investigation JO - J. Clin. Invest. VL - 56 IS - 3 N2 - Sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) is associated with electrolyte transport in many tissues. To help delineate its role in intestinal transport, changes in rat intestinal electrolyte and water transport induced by injecting methylprednisolone acetate 3 mg/100 g or deoxycorticosterone acetate (DOCA) 0.5 mg/100 g per day for 3 days were correlated with changes in Na-K-ATPase activity. Methylprednisolone increased sodium and water absorption, potassium secretion, transmural potential difference, and Na-K-ATPase activity in the jejunum, ileum, and colon. Examination of isolated epithelial cells demonstrated that the jejunal and ileal increase in Na-K-ATPase occurred in both the villus tip and crypermeability, Mg-ATPase, and adenylate cyclase activities were unchanged by methylprednisolone. DOCA increased sodium and water absorption, potassium secretion, transmural potential difference, and Na-K-ATPase activity in the colon alone. Colonic Mg-ATPase and adenylate cyclase activities were unaffected. Jejunal and ileal enzyme activity, electrolyte transport, and permeability were unchanged by DOCA. Methylprednisolone and DOCA were not additive in their effect on colonic Na-K-ATPase activity. Methylprednisolone and DOCA increased electrolyte and water transport and Na-K-ATPase activity concomitantly in specific segments of small intestine and colon. These data are consistent with an important role for Na-K-ATPase in intestinal electrolyte and water transport. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/125764/Na+_K+_activated_adenosine_triphosphatase_and_intestinal_electrolyte_transport__Effect_of_adrenal_steroids_ L2 - https://doi.org/10.1172/JCI108135 DB - PRIME DP - Unbound Medicine ER -