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Disease progression and survival of patients with positive lymph nodes after radical prostatectomy. Is there a chance of cure?
J Urol. 2003 Mar; 169(3):849-54.JU

Abstract

PURPOSE

In prostate cancer involvement of regional lymph nodes is regarded as a poor prognostic factor. Is this also true for micrometastasis if a meticulous lymph node dissection is performed? We determined progression rate and survival of patients with positive nodes following radical prostatectomy according to the number of metastases.

MATERIALS AND METHODS

Between 1989 and 1999, 367 patients with clinically organ confined prostate cancer underwent meticulous pelvic lymph node dissection and radical prostatectomy. None of the patients received immediate adjuvant therapy.

RESULTS

Of the patients 92 (25%) had histologically proven lymph node metastases. Followup of more than 1 year was available in 88 patients (96%), and median followup was 45 months (range 13 to 141). Of 19 patients (22%) who died of prostate cancer 16 had more than 1 positive node. Of the 39 patients with only 1 positive node 15 (39%) remained without signs of clinical or chemical progression. Whereas of the 20 and 29 patients with 2 or more positive lymph nodes only 2 (10%) and 4 (14%), respectively, remained disease-free. Time to prostate specific antigen relapse, symptomatic progression and tumor related death were significantly affected by the number of positive nodes.

CONCLUSIONS

Meticulous lymph node dissection reveals a high rate of metastases (25%). In patients with positive nodes time to progression is significantly correlated with the number of diseased nodes. Some patients with minimal metastatic disease remain free of prostate specific antigen relapse for more than 10 years after prostatectomy without any adjuvant treatment. Meticulous pelvic lymph node dissection, particularly in patients with micrometastases, seems not only to be a staging procedure, but may also have a positive impact on disease progression and long-term disease-free survival.

Authors+Show Affiliations

Deparment of Urology and Institute of Pathology, University of Bern, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12576797

Citation

Bader, Pia, et al. "Disease Progression and Survival of Patients With Positive Lymph Nodes After Radical Prostatectomy. Is There a Chance of Cure?" The Journal of Urology, vol. 169, no. 3, 2003, pp. 849-54.
Bader P, Burkhard FC, Markwalder R, et al. Disease progression and survival of patients with positive lymph nodes after radical prostatectomy. Is there a chance of cure? J Urol. 2003;169(3):849-54.
Bader, P., Burkhard, F. C., Markwalder, R., & Studer, U. E. (2003). Disease progression and survival of patients with positive lymph nodes after radical prostatectomy. Is there a chance of cure? The Journal of Urology, 169(3), 849-54.
Bader P, et al. Disease Progression and Survival of Patients With Positive Lymph Nodes After Radical Prostatectomy. Is There a Chance of Cure. J Urol. 2003;169(3):849-54. PubMed PMID: 12576797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disease progression and survival of patients with positive lymph nodes after radical prostatectomy. Is there a chance of cure? AU - Bader,Pia, AU - Burkhard,Fiona C, AU - Markwalder,Regula, AU - Studer,Urs E, PY - 2003/2/11/pubmed PY - 2003/2/27/medline PY - 2003/2/11/entrez SP - 849 EP - 54 JF - The Journal of urology JO - J Urol VL - 169 IS - 3 N2 - PURPOSE: In prostate cancer involvement of regional lymph nodes is regarded as a poor prognostic factor. Is this also true for micrometastasis if a meticulous lymph node dissection is performed? We determined progression rate and survival of patients with positive nodes following radical prostatectomy according to the number of metastases. MATERIALS AND METHODS: Between 1989 and 1999, 367 patients with clinically organ confined prostate cancer underwent meticulous pelvic lymph node dissection and radical prostatectomy. None of the patients received immediate adjuvant therapy. RESULTS: Of the patients 92 (25%) had histologically proven lymph node metastases. Followup of more than 1 year was available in 88 patients (96%), and median followup was 45 months (range 13 to 141). Of 19 patients (22%) who died of prostate cancer 16 had more than 1 positive node. Of the 39 patients with only 1 positive node 15 (39%) remained without signs of clinical or chemical progression. Whereas of the 20 and 29 patients with 2 or more positive lymph nodes only 2 (10%) and 4 (14%), respectively, remained disease-free. Time to prostate specific antigen relapse, symptomatic progression and tumor related death were significantly affected by the number of positive nodes. CONCLUSIONS: Meticulous lymph node dissection reveals a high rate of metastases (25%). In patients with positive nodes time to progression is significantly correlated with the number of diseased nodes. Some patients with minimal metastatic disease remain free of prostate specific antigen relapse for more than 10 years after prostatectomy without any adjuvant treatment. Meticulous pelvic lymph node dissection, particularly in patients with micrometastases, seems not only to be a staging procedure, but may also have a positive impact on disease progression and long-term disease-free survival. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/12576797/Disease_progression_and_survival_of_patients_with_positive_lymph_nodes_after_radical_prostatectomy__Is_there_a_chance_of_cure L2 - https://www.jurology.com/doi/10.1097/01.ju.0000049032.38743.c7?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -