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Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population.
Nat Genet. 2003 Mar; 33(3):412-5.NGen

Abstract

Leprosy, a chronic infectious disease caused by Mycobacterium leprae, affects an estimated 700,000 persons each year. Clinically, leprosy can be categorized as paucibacillary or multibacillary disease. These clinical forms develop in persons that are intrinsically susceptible to leprosy per se, that is, leprosy independent of its specific clinical manifestation. We report here on a genome-wide search for loci controlling susceptibility to leprosy per se in a panel of 86 families including 205 siblings affected with leprosy from Southern Vietnam. Using model-free linkage analysis, we found significant evidence for a susceptibility gene on chromosome region 6q25 (maximum likelihood binomial (MLB) lod score 4.31; P = 5 x 10(-6)). We confirmed this by family-based association analysis in an independent panel of 208 Vietnamese leprosy simplex families. Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively).

Authors+Show Affiliations

McGill Centre for the Study of Host Resistance and Department of Human Genetics, McGill University, 1650 Cedar Avenue, Montreal, H3G 1A4 PQ, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12577057

Citation

Mira, Marcelo T., et al. "Chromosome 6q25 Is Linked to Susceptibility to Leprosy in a Vietnamese Population." Nature Genetics, vol. 33, no. 3, 2003, pp. 412-5.
Mira MT, Alcaïs A, Van Thuc N, et al. Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. Nat Genet. 2003;33(3):412-5.
Mira, M. T., Alcaïs, A., Van Thuc, N., Thai, V. H., Huong, N. T., Ba, N. N., Verner, A., Hudson, T. J., Abel, L., & Schurr, E. (2003). Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. Nature Genetics, 33(3), 412-5.
Mira MT, et al. Chromosome 6q25 Is Linked to Susceptibility to Leprosy in a Vietnamese Population. Nat Genet. 2003;33(3):412-5. PubMed PMID: 12577057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. AU - Mira,Marcelo T, AU - Alcaïs,Alexandre, AU - Van Thuc,Nguyen, AU - Thai,Vu Hong, AU - Huong,Nguyen Thu, AU - Ba,Nguyen Ngoc, AU - Verner,Andrei, AU - Hudson,Thomas J, AU - Abel,Laurent, AU - Schurr,Erwin, Y1 - 2003/02/10/ PY - 2002/09/23/received PY - 2003/01/06/accepted PY - 2003/2/11/pubmed PY - 2003/3/26/medline PY - 2003/2/11/entrez SP - 412 EP - 5 JF - Nature genetics JO - Nat. Genet. VL - 33 IS - 3 N2 - Leprosy, a chronic infectious disease caused by Mycobacterium leprae, affects an estimated 700,000 persons each year. Clinically, leprosy can be categorized as paucibacillary or multibacillary disease. These clinical forms develop in persons that are intrinsically susceptible to leprosy per se, that is, leprosy independent of its specific clinical manifestation. We report here on a genome-wide search for loci controlling susceptibility to leprosy per se in a panel of 86 families including 205 siblings affected with leprosy from Southern Vietnam. Using model-free linkage analysis, we found significant evidence for a susceptibility gene on chromosome region 6q25 (maximum likelihood binomial (MLB) lod score 4.31; P = 5 x 10(-6)). We confirmed this by family-based association analysis in an independent panel of 208 Vietnamese leprosy simplex families. Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D6S1035 and D6S305) showed strong evidence for association with leprosy (P = 6.7 x 10(-4) and P = 5.9 x 10(-5), respectively). SN - 1061-4036 UR - https://www.unboundmedicine.com/medline/citation/12577057/Chromosome_6q25_is_linked_to_susceptibility_to_leprosy_in_a_Vietnamese_population_ L2 - http://dx.doi.org/10.1038/ng1096 DB - PRIME DP - Unbound Medicine ER -