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Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma.
Ophthalmology 2003; 110(2):359-62; discussion 362-4O

Abstract

OBJECTIVE

To evaluate the effect of Ginkgo biloba extract (GBE) on preexisting visual field damage in patients with normal tension glaucoma (NTG).

DESIGN

Prospective, randomized, placebo-controlled, double-masked cross-over trial.

PARTICIPANTS

Twenty-seven patients with bilateral visual field damage resulting from NTG.

INTERVENTION

Patients received 40 mg GBE, administered orally, three times daily for 4 weeks, followed by a wash-out period of 8 weeks, then 4 weeks of placebo treatment (identical capsules filled with 40 mg fructose). Other patients underwent the same regimen, but took the placebo first and the GBE last. Visual field tests, performed at baseline and at the end of each phase of the study, were evaluated for changes.

MAIN OUTCOME MEASURES

Change in visual field and any ocular or systemic complications.

RESULTS

After GBE treatment, a significant improvement in visual fields indices was recorded: mean deviation (MD) at baseline versus MD after GBE treatment, 11.40 +/- 3.27 dB versus 8.78 +/- 2.56 dB (t = 8.86, P = 0.0001, chi-square test); corrected pattern standard deviation (CPSD) at baseline versus CPSD after GBE treatment, 10.93 +/- 2.12 dB versus 8.13 +/- 2.12 dB (t = 9.89, P = 0.0001, chi-square test). No significant changes were found in intraocular pressure, blood pressure, or heart rate after placebo or GBE treatment. Any ocular and systemic side effects were recorded for the duration of the trial.

CONCLUSIONS

Ginkgo biloba extract administration appears to improve preexisting visual field damage in some patients with NTG.

Authors+Show Affiliations

Centro Glaucoma, Clinica Oculistica Università di Brescia, 25123 Brescia, Italy. Quaranta@med.unibs.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12578781

Citation

Quaranta, Luciano, et al. "Effect of Ginkgo Biloba Extract On Preexisting Visual Field Damage in Normal Tension Glaucoma." Ophthalmology, vol. 110, no. 2, 2003, pp. 359-62; discussion 362-4.
Quaranta L, Bettelli S, Uva MG, et al. Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. Ophthalmology. 2003;110(2):359-62; discussion 362-4.
Quaranta, L., Bettelli, S., Uva, M. G., Semeraro, F., Turano, R., & Gandolfo, E. (2003). Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. Ophthalmology, 110(2), pp. 359-62; discussion 362-4.
Quaranta L, et al. Effect of Ginkgo Biloba Extract On Preexisting Visual Field Damage in Normal Tension Glaucoma. Ophthalmology. 2003;110(2):359-62; discussion 362-4. PubMed PMID: 12578781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. AU - Quaranta,Luciano, AU - Bettelli,Sabina, AU - Uva,Maurizio G, AU - Semeraro,Francesco, AU - Turano,Raffaele, AU - Gandolfo,Enrico, PY - 2003/2/13/pubmed PY - 2003/3/4/medline PY - 2003/2/13/entrez SP - 359-62; discussion 362-4 JF - Ophthalmology JO - Ophthalmology VL - 110 IS - 2 N2 - OBJECTIVE: To evaluate the effect of Ginkgo biloba extract (GBE) on preexisting visual field damage in patients with normal tension glaucoma (NTG). DESIGN: Prospective, randomized, placebo-controlled, double-masked cross-over trial. PARTICIPANTS: Twenty-seven patients with bilateral visual field damage resulting from NTG. INTERVENTION: Patients received 40 mg GBE, administered orally, three times daily for 4 weeks, followed by a wash-out period of 8 weeks, then 4 weeks of placebo treatment (identical capsules filled with 40 mg fructose). Other patients underwent the same regimen, but took the placebo first and the GBE last. Visual field tests, performed at baseline and at the end of each phase of the study, were evaluated for changes. MAIN OUTCOME MEASURES: Change in visual field and any ocular or systemic complications. RESULTS: After GBE treatment, a significant improvement in visual fields indices was recorded: mean deviation (MD) at baseline versus MD after GBE treatment, 11.40 +/- 3.27 dB versus 8.78 +/- 2.56 dB (t = 8.86, P = 0.0001, chi-square test); corrected pattern standard deviation (CPSD) at baseline versus CPSD after GBE treatment, 10.93 +/- 2.12 dB versus 8.13 +/- 2.12 dB (t = 9.89, P = 0.0001, chi-square test). No significant changes were found in intraocular pressure, blood pressure, or heart rate after placebo or GBE treatment. Any ocular and systemic side effects were recorded for the duration of the trial. CONCLUSIONS: Ginkgo biloba extract administration appears to improve preexisting visual field damage in some patients with NTG. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/12578781/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(02)01745-1 DB - PRIME DP - Unbound Medicine ER -