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[Association of coagulation factor V, VII gene polymorphisms with coronary heart disease].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Feb; 20(1):39-42.ZY

Abstract

OBJECTIVE

To study the distribution of coagulation factor V(FV), VII(FVII) gene polymorphisms in Chinese Han population and the association of the polymorphisms with coronary heart disease(CHD).

METHODS

Genotypes of FV FVII were typed in 234 CHD patients and 210 controls by polymerase chain reaction-restriction fragment length polymorphism. Selected coronary angiography was performed in 234 CHD patients.

RESULTS

FVII allelic frequencies of R,Q and H7,H6 were 94.6%, 5.6%, 70.3%, 29.7% and 91.9%, 8.1%, 60.9%, 39.1% in CHD group and control group respectively. Genotype distribution was in accordance with Hardy-Weinberg equilibrium. There was no significant difference in frequencies of allele and genotype in R353Q or HVR4 polymorphisms between CHD group and control group. The distribution of allele and genotype in R353Q was of significant difference between non-myocardial infarction subgroup and myocardial infarction subgroup (chi2 = 4.711, P<0.05, OR=0.37,95% CI: 0.15-0.94). However, HVR4 polymorphism was not found to be of significant difference within two group (chi2 = 0.142, P>0.05). There was no FV Leiden mutation in all the CHD patients and normal controls.

CONCLUSION

The Q allele of the R353Q polymorphism of the FVII gene may be a protective factor against myocardial infarction.

Authors+Show Affiliations

Department of Cardiology, the Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

12579498

Citation

Xu, Geng, et al. "[Association of Coagulation Factor V, VII Gene Polymorphisms With Coronary Heart Disease]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 20, no. 1, 2003, pp. 39-42.
Xu G, Jin GD, Fu GS, et al. [Association of coagulation factor V, VII gene polymorphisms with coronary heart disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20(1):39-42.
Xu, G., Jin, G. D., Fu, G. S., Ma, J., & Shan, J. (2003). [Association of coagulation factor V, VII gene polymorphisms with coronary heart disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 20(1), 39-42.
Xu G, et al. [Association of Coagulation Factor V, VII Gene Polymorphisms With Coronary Heart Disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20(1):39-42. PubMed PMID: 12579498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of coagulation factor V, VII gene polymorphisms with coronary heart disease]. AU - Xu,Geng, AU - Jin,Guo-dong, AU - Fu,Guo-sheng, AU - Ma,Ji, AU - Shan,Jiang, PY - 2003/2/13/pubmed PY - 2003/9/3/medline PY - 2003/2/13/entrez SP - 39 EP - 42 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 20 IS - 1 N2 - OBJECTIVE: To study the distribution of coagulation factor V(FV), VII(FVII) gene polymorphisms in Chinese Han population and the association of the polymorphisms with coronary heart disease(CHD). METHODS: Genotypes of FV FVII were typed in 234 CHD patients and 210 controls by polymerase chain reaction-restriction fragment length polymorphism. Selected coronary angiography was performed in 234 CHD patients. RESULTS: FVII allelic frequencies of R,Q and H7,H6 were 94.6%, 5.6%, 70.3%, 29.7% and 91.9%, 8.1%, 60.9%, 39.1% in CHD group and control group respectively. Genotype distribution was in accordance with Hardy-Weinberg equilibrium. There was no significant difference in frequencies of allele and genotype in R353Q or HVR4 polymorphisms between CHD group and control group. The distribution of allele and genotype in R353Q was of significant difference between non-myocardial infarction subgroup and myocardial infarction subgroup (chi2 = 4.711, P<0.05, OR=0.37,95% CI: 0.15-0.94). However, HVR4 polymorphism was not found to be of significant difference within two group (chi2 = 0.142, P>0.05). There was no FV Leiden mutation in all the CHD patients and normal controls. CONCLUSION: The Q allele of the R353Q polymorphism of the FVII gene may be a protective factor against myocardial infarction. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/12579498/[Association_of_coagulation_factor_V_VII_gene_polymorphisms_with_coronary_heart_disease]_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -